INFLUENCE OF NUTRITION AND GENETICS ON PERFORMANCE: A PILOT STUDY IN A GROUP OF GYMNASTS

Purpose. Energy requirements in sports performance are affected by numerous factors: physical characteristics, age, genetic basis, sports discipline. The Food and Nutrition Board recommended nutrition based on age, height, and body weight gain in relation to physical activity. Some genetic factors, such as the PPAR-encoding gene, play a key role in metabolism. The aim of the study was to investigate the effect of specific snacks on performance. Methods. Seventeen girls aged 10–14 years practising artistic gymnastics were enrolled. A carb or protein/carb snack was provided before the training, and a questionnaire was administered at the end. In addition, saliva samples were collected for genetic analyses. Results. Most girls represented the CC genotype (65%), while a small part had the GC (23%) and GG (12%). The average BMI equalled 20.05 ± 2.8 kg/m2 in the group with the CC genotype, 19.6 ± 2.8 kg/m2 with the GC genotype, and 20.2 ± 2.8 kg/m2 with the GG genotype. The questionnaire showed that 59% of girls experienced a performance improvement after eating a carb snack; slightly different results were observed after the intake of a protein/carb snack: 47% felt more energy and 12% more fatigue. Conclusions. This is a preliminary study that should be deepened by increasing the number of subjects, as well as diversifying the type of snacks administered and increasing the time of the study. It is important to be mindful of eating habits and lifestyle in order to prevent the onset of overweight

Trend of Drug Abuse in 2011– 2014 in Italy

Doping, although was born as a medication and not with the purpose of enhancing performance, is a widespread practice in all sports, between amateur and gym-goers. The Italian sports federations were in second place worldwide for positive doping-test, after Russia. This review focuses on the analysis of data collected by Italian National Olympic Committee (CONI) in the 2012–2014 period, showing that the most commonly used substances were anabolic androgenic agents, glucocorticoids, diuretics and stimulants. Prevention in doping could be a key to limit the damage caused by this harmful practice both, for the physical health and the athlete’s moral integrity and anti-doping campaigns should be direct as much as possible to young people, since about two-thirds of adolescents appear to be dissatisfied with their body. Even coordination between the various professionals that surround athletes could help fight doping by planning specific training and adapted to the individual athlete, taking into account the actual physical limitations and physical features of each

Nutritional supplement habits: the survey on a Sicilian group

Dietary supplements are extensively used among athletes as well as amateurs attending gyms. Regardless of very poorly investigated information about the effects of these products – both desirable and adverse – a wide range of population is used to take them. The aim of this study was to investigate the supplement consumption in Sicilia, Italy. An online questionnaire has been administered to 588 subjects (55% male and 45% female) aged between 15 and 53 years, frequenters and non-frequenters of gyms. The questionnaire showed that 75% of subjects practice (more or less regularly) physical activity 3-4 times a week, whilst the 25% did not practice any sport. Saline Supplements (Gatorade, Powerade, etc.), Branched Amino Acids (BCAAs) and protein supplements were the most frequently indicated dietary supplements (25.2%, 19.4% and 27%); carnitine and creatine the least (6.8% and 11.6%). Most of the practicing sport respondents administer nutritional supplements by themselves and they do not acknowledge any noticeable performance improvement. Therefore, even if there is no definite posology for the use of supplements, these should never be considered as an alternative to foods and a proper lifestyle

Nutritional supplement habits: the survey on a Sicilian group

Dietary supplements are extensively used among athletes as well as amateurs attending gyms. Regardless of very poorly investigated information about the effects of these products \u2013 both desirable and adverse \u2013 a wide range of population is used to take them. The aim of this study was to investigate the supplement consumption in Sicilia, Italy. An online questionnaire has been administered to 588 subjects (55% male and 45% female) aged between 15 and 53 years, frequenters and non-frequenters of gyms. The questionnaire showed that 75% of subjects practice (more or less regularly) physical activity 3-4 times a week, whilst the 25% did not practice any sport. Saline Supplements (Gatorade, Powerade, etc.), Branched Amino Acids (BCAAs) and protein supplements were the most frequently indicated dietary supplements (25.2%, 19.4% and 27%); carnitine and creatine the least (6.8% and 11.6%). Most of the practicing sport respondents administer nutritional supplements by themselves and they do not acknowledge any noticeable performance improvement. Therefore, even if there is no definite posology for the use of supplements, these should never be considered as an alternative to foods and a proper lifestyle

Influence of Nutrition and Genetics on Performance: A Pilot Study in a Group of Gymnasts

Purpose. Energy requirements in sports performance are affected by numerous factors: physical characteristics, age, genetic basis, sports discipline. The Food and Nutrition Board recommended nutrition based on age, height, and body weight gain in relation to physical activity. Some genetic factors, such as the PPAR-encoding gene, play a key role in metabolism. The aim of the study was to investigate the effect of specific snacks on performance. Methods. Seventeen girls aged 10-14 years practising artistic gymnastics were enrolled. A carb or protein/carb snack was provided before the training, and a questionnaire was administered at the end. In addition, saliva samples were collected for genetic analyses. Results. Most girls represented the CC genotype (65%), while a small part had the GC (23%) and GG (12%). The average BMI equalled 20.05 ± 2.8 kg/m2 in the group with the CC genotype, 19.6 ± 2.8 kg/m2 with the GC genotype, and 20.2 ± 2.8 kg/m2 with the GG genotype. The questionnaire showed that 59% of girls experienced a performance improvement after eating a carb snack; slightly different results were observed after the intake of a protein/carb snack: 47% felt more energy and 12% more fatigue. Conclusions. This is a preliminary study that should be deepened by increasing the number of subjects, as well as diversifying the type of snacks administered and increasing the time of the study. It is important to be mindful of eating habits and lifestyle in order to prevent the onset of overweight

An innovative way to highlight the power of each polymorphism on elite athletes phenotype expression

The purpose of this study was to determine the probability of soccer players having the best genetic background that could increase performance, evaluating the polymorphism that are considered Performance Enhancing Polymorphism (PEPs) distributed on five genes: PPARα, PPARGC1A, NRF2, ACE e CKMM. Particularly, we investigated how each polymorphism works directly or through another polymorphism to distinguish elite athletes from non-athletic population. Sixty professional soccer players (age 22.5 ± 2.2) and sixty healthy volunteers (age 21.2± 2.3) were enrolled. Samples of venous blood was used to prepare genomic DNA. The polymorphic sites were scanned using PCR-RFLP protocols with different enzyme. We used a multivariate logistic regression analysis to demonstrate an association between the five PEPs and elite phenotype. We found statistical significance in NRF2 (AG/GG genotype) polymorphism/soccer players association (p<0.05) as well as a stronger association in ACE polymorphism (p=0.02). Particularly, we noticed that the ACE ID genotype and even more the II genotype are associated with soccer player phenotype. Although the other PEPs had no statistical significance, we proved that some of these may work indirectly, amplifying the effect of another polymorphism; for example, seems that PPARα could acts on NRF2 (GG) enhancing the effect of the latter, notwithstanding it had not shown a statistical significance. In conclusion, to establish if a polymorphism can influence the performance, it is necessary to understand how they act and interact, directly and indirectly, on each othe

Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer

J Clin Oncol. 2005 Feb 1;23(4):808-15. Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer. Boccardo F, Rubagotti A, Battaglia M, Di Tonno P, Selvaggi FP, Conti G, Comeri G, Bertaccini A, Martorana G, Galassi P, Zattoni F, Macchiarella A, Siragusa A, Muscas G, Durand F, Potenzoni D, Manganelli A, Ferraris V, Montefiore F. Source University and National Cancer Research Institute, University of Genoa, Genoa, Italy. [email protected] Abstract PURPOSE: To determine whether tamoxifen or anastrozole prevents gynecomastia and breast pain caused by bicalutamide (150 mg) without compromising efficacy, safety, or sexual functioning. PATIENTS AND METHODS: A double-blind, placebo-controlled trial was performed in patients with localized, locally advanced, or biochemically recurrent prostate cancer. Patients (N = 114) were randomly assigned to either bicalutamide (150 mg/d) plus placebo or in combination with tamoxifen (20 mg/d) or anastrozole (1 mg/d) for 48 weeks. Gynecomastia, breast pain, prostate-specific antigen (PSA), sexual functioning, and serum levels of hormones were assessed. RESULTS: Gynecomastia developed in 73% of patients in the bicalutamide group, 10% of patients in the bicalutamide-tamoxifen group, and 51% of patients in the bicalutamide-anastrozole group (P or = 50% in 97%, 97%, and 83% of patients in the bicalutamide, bicalutamide-tamoxifen, and bicalutamide-anastrozole groups, respectively (P = .07); and adverse events were reported in 37%, 35%, and 69% of patients, respectively (P = .004). There were no major differences among treatments in sexual functioning parameters from baseline to month 6. Elevated testosterone levels occurred in each group; however, free testosterone levels remained unchanged in the bicalutamide-tamoxifen group because of increased sex hormone-binding globulin levels. CONCLUSION: Anastrozole did not significantly reduce the incidence of bicalutamide-induced gynecomastia and breast pain. In contrast, tamoxifen was effective, without increasing adverse events, at least in the short-term follow-up. These data support the need for a larger study to determine any effect on mortalit