Effects of MHC class I<i>A</i> and II haplotypes on IL-10 and α-defensin production during SHIV_SF162P4cy infection.

<p>Mean values with standard error are depicted for all animals positive or negative for the indicated haplotype: M3 (n = 9) non-M3 (n = 12) class I<i>A</i>; M3 (n = 13) non-M3 (n = 8) class II.</p

Plasma α-defensin, IL-10 and IFN-γ levels with respect to the pre-infection values in naïve (n = 11) and adjuvant treated monkeys (n = 10) inoculated with SHIV_SF162P4cy.

<p>No significant differences were observed between naive and adjuvant treated monkeys during the observation period. Mean values with standard deviations are connected by dotted lines.</p

Effects of MHC class I<i>A</i> and I<i>B</i> haplotypes on IgG anti-Env antibodies and neutralizing Ab following infection with SHIV_SF162P4cy.

<p>Mean values with standard error are depicted for all animals positive or negative for the indicated haplotype: M4 (n = 6) non-M4 (n = 15) class I<i>A</i>; M4 (n = 7), non-M4 (n = 14) class I<i>B</i>.</p

Regression analyses between immunological and virological parameters in infected monkeys during the acute phase of SHIV_SF162P4cy infection.

<p>A significant relationship was detected between: A) IL-10 production and plasma viral load (p = 0.0023); B) α-defensins production and viral RNA (p = 0.0286); C) IFNγ and IL-10 production (p<0.0001). D) AUC: significant relationship between viral load and α-defensins (p = 0.0002).</p

Dynamics of viral infection in 21 cynomolgus monkeys inoculated with SHIV_SF162P4cy during acute (2–4 weeks p.i.), post-acute (8–16 weeks p.i.) of infection.

<p>Data represent mean values with standard error of log plasma RNA load, log proviral DNA, IgG anti-Env Ab, and nAb from 0 to 16 weeks p.i. (*) week 4: anti-Env bAb titers correlated positively with viral load (p = 0.0002); (**) week 16: nAb titers correlated positively with anti-Env bAb titers (p = 0.0041); (***) post-acute phase: proviral DNA levels correlated positively with anti-Env bAb (p = 0.0225) and negatively with nAb titers (p = 0.0083).</p

Frequency of MHC class IA, class IB and class II and recombinant haplotypes in animals included in the study.

<p>Animals carrying specific Mhc class I haplotypes. MHC class IA: M1 = 7, M2 = 5, M3 = 9, M4 = 6, M5 = 1, M6 = 2, M7 = 4, rec = 6; frequency of MHC class IB: M1 = 9, M2 = 5, M3 = 11, M4 = 7, M5 = 1, M6 = 3, M7 = 4, rec = 1; frequency of MHC class II: M1 = 9, M2 = 4, M3 = 13, M4 = 6, M5 = 1, M6 = 4, M7 = 3, rec = 2 <i>rec</i> recombinant haplotype.</p