Multicriteria Evaluation of Urban Regeneration Processes: An Application of PROMETHEE Method in Northern Italy

The paper illustrates the development of an evaluation model for supporting the decision-making process related to an urban regeneration intervention. In particular, the study proposes an original multi-methodological approach, which combines SWOT Analysis, Stakeholders Analysis and PROMETHEE method for the evaluation of alternative renewal strategies of an urban area in Northern Italy. The article also describes the work carried out within an experts' panel that has been organized for validating the structuring of the decision problem and for evaluating the criteria of the model

Decision-Making for Urban Planning and Regional Development

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Mountain protective forests under threat? an in-depth review of global change impacts on their protective effect against natural hazards

Forests in mountain areas provide an indispensable ecosystem service by protecting people and infrastructure against natural hazards. As forests are increasingly affected by global change, including climate change, more frequent and severe natural disturbances, and shifts in land use, open questions remain regarding the long-term and sustainable provision of this crucial protective service. To improve our understanding of the various effects of global change on protective forests, we summarized the current knowledge based on a systematic review. Focusing on changes in mountain forests’ protective effect against snow avalanches, landslides, rockfall, torrential floods and debris flow, we assessed 72 peer-reviewed, English publications. Overall, climate-induced changes are expected to increase forests’ protective effect at higher elevations but reduce it at lower elevations mainly due to increased drought. Natural disturbances usually decrease the protective effect of forests, and their impact is often further exacerbated by salvage logging. Different forest management strategies are often studied using forest simulation models, and their impacts on protective forests strongly depend on the local context and interactions with climate change. While clearcuts consistently reduce the protective effect, other forest management interventions such as thinning can have either positive or negative effects. Most of the reviewed studies were case studies based on forest simulation or process-based hazard models (but rarely combining the two), while empirical evidence was scarce. Forests’ protective effect is often assessed using (diverse) indicators of forest structure, but evaluations of resulting risks are less common. More consistent modeling approaches linking forest structure to hazard and risk, as well as consistent indicators across different case studies, are needed for a better understanding of changes in protective forests and the service they provide under global change

Mycobiota composition of robiola di roccaverano cheese along the production chain

Robiola di Roccaverano is a Protected Designation of Origin (PDO) cheese from the Piedmont region of Italy. In this study, the mycobiota occurring during Robiola di Roccaverano production was elucidated. Samples of milk, Natural Milk Cultures (NMC), curd, 5- and 15-days ripened cheese were collected from one dairy plant and the mycobiota was analyzed by the metataxonomic approach. Milk samples showed a high diversity and Cladosporium, Kluyveromyces marxianus, Geotrichum candidum and Debaryomyces hansenii were found with higher relative abundance. This mycobiota remains quite stable in NMC and curd matrices although the relative abundance of K. marxianus and G. candidum yeasts increased significantly and shaped the fungal composition of 5- and 15-day ripened cheese

SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma

Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread. SCD5 is significantly expressed in primary melanoma, but becomes barely detectable at tumor advanced stages. Looking for the regulatory mechanisms underlying SCD5 reduced expression during melanoma progression, we demonstrated a significantly lower stability of SCD5 protein as well as the direct targeting of SCD5 mRNA by the oncogenic miR-221 & 222 in metastatic cell lines. Moreover, our results indicated the existence of a negative feedback loop between SCD5 and miR-221 & 222, in good agreement with their opposite functions. Also, we showed how SCD5 re-expression and the direct supplementation of its main product oleic acid (OA) can drive advanced melanoma cell lines toward differentiation and reversion of the epithelial-mesenchymal (EMT)-like process, eventually inducing a less malignant phenotype. Indeed, SCD5 re-established the sensitivity to all-trans retinoic acid in A375M metastatic melanoma, associated with increased levels of Tyrosinase, melanin production and reduced proliferation. As evidenced by the correct modulation of some key transcription factors, SCD5 managed by favoring a partial mesenchymal-to-epithelial (MET) transition in in vitro studies. Interestingly, a more complete MET, including E-cadherin re-expression correctly localized at cell membranes, was obtained in in vivo xenograft models, thus indicating the requirement of direct contacts between tumor cells and the surrounding microenvironment as well as the presence of some essential factors for SCD5 complete function