Tuberculosus: philosophy of vitality

The aim of the work is to examine the relationship of philosophical, sociological and psychological approaches to the problem of ТВ in the situation of the disease. Materials and Methods. Philosophical reflection on the phenomenon of tuberculosis as a disease was based on the existential and structuralist approaches. Sociological analysis included the use of quantitative and qualitative methodologies to explore the social factors or determinants of tuberculosis. Psychological instruments were used to identify internal potential of the disease, the level of viability, its impact on the treatment process, situation analysis of the disease as a stressful mental state. Results. It was noted that the level of vitality is almost equal to the reference values which were average results of a survey of patients with an active ТВ of men of the third department. Conclusions. It was concluded that the Vitality Test revealed the correlation between criteria of viability and patient's compliance, which could help in predicting the treatment effectiveness and management of patients

Comparative structural and functional characteristics of different forms of saccharomyces cerevisiae red pigment and its synthetic analogue

Structural and functional characteristics of the yeast red pigment (product of polymerization of N'-flí-D-ri-bofuranosyl)-5-aminoimadazole), isolated from adel 1 mutant cells of Saccharomyces cerevisiae, its deribosy-lated derivatives (obtained by acid hydrolysis) and its synthetic pigment analogue (product of polymerization of N'-methyl-5-aminoimadazole in vitro) has been obtained. Products of in vitro polymerization were identified using mass spectrometry. The ability of these pigments to inhibit amyloid formation using insulin fibrils was compared. The entire compounds studied were able to interact with amyloids and inhibit their growth. Electron and atomic force microscopy revealed a common feature inherent in the insulin fibrils formed in presence of these compounds - they were merged into conglomerates that were more stable and resistant to the effects of ultrasound in comparison with insulin aggregates grown without pigments. We speculate that all these compounds can cause coalescence of fibrils, partially block their loose ends and, thereby, inhibit the attachment of new monomers to growing fibril

Structural and functional characteristics of various forms of red pigment of yeast Saccharomyces cerevisiae and its synthetic analog

Structural and functional characteristics of the yeast red pigment (product of polymerization of N1-(β-D-ribofuranosyl)-5-aminoimidazole), isolated from ade1 mutant cells of Saccharomyces cerevisiae and its deribosylated derivatives (obtained by acid hydrolysis) and its synthetic pigment analogue (product of polymerization of N1-methyl-5-aminoimidazole in vitro) were obtained. Products of in vitro polymerization were identified using mass spectrometry. The ability of these pigments to inhibit amyloid formation using insulin fibrils was compared. All the studied compounds are able to interact with amyloids and inhibit their growth. Electron and atomic force microscopy revealed a common feature inherent in the insulin fibrils formed in the presence of these compounds—they are merged into conglomerates more stable and resistant to the effects of ultrasound than are insulin aggregates grown without pigments. We suggest that all these compounds can cause coalescence of fibrils partially blocking the loose ends and, thereby, inhibit attachment of monomers and formation of new fibril