Exploiting the extemporaneousness of radiopharmaceuticals: Radiolabeling stability under diverse conditions

Radiopharmaceuticals are radioactive drugs, with a very short shelf life, in most of the cases. The number of proceedings using radiopharmaceuticals increases each day worldwide and for many countries the price of radiopharmaceuticals can represent a limitation in the offer of this drug for more patients. Nonetheless, the shortage of important radionuclides is a serious issue and may also affect the use and distribution of these drugs for more patients globally, especially in low and middle income countries. In this direction, the need to avoid waste of these drugs is crucial. In this study we have evaluated the stability of two radiopharmaceuticals (MDP and DTPA) under different conditions in order to propose the extension of shelf life. The results showed that is possible to have stable radiopharmaceuticals (both MDP and DTPA) even 24hs post labeling process when storage properly. The data may represent an advance in the field of Radiopharmacy, providing news perspectives for radiopharmaceuticals shelf life. © 2022 Elsevier B.V.E-26//211.207/2021, E-26/202.320/2021; E-26/010.002362/2019, E-26/211.269/2021; Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq: 301069/2018-2; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, FAPERJ: E-26/010.000981/2019, E-26/200.815/2021; Comissão Nacional de Energia Nuclear, CNEN: 01341.011064/2021-71This study was funded by Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State ( FAPERJ ) ( Cientista do Nosso Estado : E-26/200.815/2021 ; Rede NanoSáude : E-26/010.000981/2019 , Pesquisa na UEZO : E-26/010.002362/2019 ; Temáticos : E-26/211.269/2021 , Infraestrutura e Pesquisa na UEZO e UERJ : E-26//211.207/2021 , Bolsa de Pós Doutorado Senior (PDS): E-26/202.320/2021 ); CNPq (Bolsa de Produtividade 1B: 301069/2018-2 ) to Ralph Santos-Oliveira; National Nuclear Energy Commission (Bolsa de Pós-doutorado CNEN: 01341.011064/2021-71 ) to Martha Sahylí Ortega Pijeira