Hope And Pediatric Cancer

Pediatric cancer is rare when compared to the incidence of cases in adults. In Brazil it is the second largest cause of death by disease in children and adolescents. Cancer is a life-altering disease that brings with it fear, disbelief, anger, uncertainty, devastation, at the time it is diagnosed. In childhood cancer, diagnosis extends to the whole family. The diagnosis brings psychological and social changes in family dynamics and needs emotional support, discussion of possible therapies and possible death. Hope comes, bringing with it a meaning in illness, contributing positively to a better adaptation and adherence to treatment and consequently the quality and the prospect of life. Hope has been shown as a positive factor when facing this new reality. However there are few studies dealing with this issue

Borderline personality disorder in twins: The preponderance of environmental and genetic factors

The borderline personality disorder is a psychiatric disorder that despite being widely researched, still has limitations in addressing certain issues involving the degree of genetic and environmental influence. Although studies indicate the existence of such influences, little had research on different prevalences in twins

The HLA-DRB1 Alleles Effects on Multiple Sclerosis:a Systematic Review

Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that affects sensitive and motor functions. Many population studies were made with the intent of knowing better the most affected groups and the disease manifestations. These review analyses some of those studies, evaluating risk factors, especially genetic relations of Human Leukocyte Antigen DRB1 (HLADRB1) gens, for developing clinical disease.Method: We have analyzed 57 articles, published between 2009 and 2014, with the key words “multiple sclerosisâ€, “genetic association studies†and “HLA-DRB1 chainsâ€, through the Scopus database. Only 18 articles were eligible for our study; they were read entirely and included in the fial analysis.Results: Most studies imply genetic and environmental factors for the incidence of MS, its age of starting and prognosis. Previous studies have shown that many gens are related in MS pathogenesis and that interactions between them are important in determining clinicalmanifestations.Limitations: Different results were observed when different populations were targeted in the studies.Conclusion: There is an important relation between HLA-DRB1 and MS in diverse population groups. Complementary studies are needed to know better the importance of environmental factors and its interaction with gens in the development of MS

Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama

Diabetes Mellitus is one of the most common causes of neuropathies, which can be caused by molecular imbalances that impair metabolic pathways. Studies in rats showed the importance of sirtuins (SIRT), deacetylases that use NAD+ as a cofactor, which have a widespread function in metabolism, and their relation when food deprived or calorie restricted. Additionally, diabetic neuropathy presents different structural biomarkers that cause morphological alterations in fibers that can be partially treated. SIRT1 is the principal sirtuin, which acts on hypothalamus, liver, kidney, among other organs, up regulating or down regulating the expression of some genes or enzymes crucial in the process of glucose absorption