Folded Three-Spin String Solutions in AdS_5 x S^5

We construct a spinning closed string solution in AdS_5 x S^5 which is folded in the radial direction and has two equal spins in AdS_5 and a spin in S^5. The energy expression of the three-spin solution specified by the folding and winding numbers for the small S^5 spin shows a logarithmic behavior and a one-third power behavior of the large total AdS_5 spin, in the long string and in the short string located near the boundary of AdS_5 respectively. It exhibits the non-regular expansion in the 't Hooft coupling constant, while it takes the regular one when the S^5 spin becomes large.Comment: 14 pages, LaTeX, no figures, a reference adde

Multi-spin strings on AdS(5)xT(1,1) and operators of N=1 superconformal theory

We study rotating strings with multiple spins in the background of $AdS_5\times T^{1,1}$, which is dual to a $\mathcal{N}=1$ superconformal field theory with global symmetry $SU(2)\times SU(2)\times U(1)$ via the AdS/CFT correspondence. We analyse the limiting behaviour of macroscopic strings and discuss the identification of the dual operators and how their anomalous dimensions should behave as the global charges vary. A class of string solutions we find are dual to operators in SU(2) subsector, and our result implies that the one-loop planar dilatation operator restricted to the SU(2) subsector should be equivalent to the hamiltonian of the integrable Heisenberg spin chain.Comment: 8 pages, revtex4, twocolum

Spinning Pulsating String Solitons in AdS_5 x S^5

We point out the existence of some simple string solitons in AdS_5 x S^5, which at the same time are spinning in AdS_5 and pulsating in S^5, or vice-versa. This introduces an additional arbitrary constant into the scaling relations between energy and spin or R-charge. The arbitrary constant is not an angular momentum, but can be related to the amplitude of the pulsation. We discuss the solutions in detail and consider the scaling relations. Pulsating multi spin or multi R-charge solutions can also be constructed.Comment: 15 pages, Late

Сонографические показатели диафрагмы и их корреляции со спирометрическими данными у здоровых лиц: проспективное клиническое исследование

ЦЕЛЬ ИССЛЕДОВАНИЯ: Выявить корреляционные взаимосвязи сонографических показателей функционирования диафрагмы со спирометрическими данными у здоровых лиц. МАТЕРИАЛЫ И МЕТОДЫ: На базе ФГБУ «НМИЦ им. В.А. Алмазова» у 50 здоровых добровольцев (женщин — 30) оценили структурное (толщину) и функциональное (индекс утолщения и экскурсию) состояние диафрагмы с помощью ультразвукового исследования, а также спирометрические характеристики аппарата внешнего дыхания с помощью аппарата искусственной вентиляции легких. После чего провели статистическую обработку и корреляционный анализ. РЕЗУЛЬТАТЫ: Толщину диафрагмы (слева и справа) и ее экскурсию (справа) удалось оценить у всех испытуемых; экскурсию диафрагмы слева — только у 20 % испытуемых. Спирометрию выполнили у всех испытуемых. Полученные данные согласуются с литературными. В частности, ультразвуковые и спирометрические показатели для здоровых лиц находились в рамках референтных значений. Сила инспираторных мышц также оказалась сопоставимой с литературными данными. Корреляционный анализ не выявил статистически значимых взаимосвязей между изученными ультразвуковыми и спирометрическими параметрами. Также не было выявлено взаимосвязи между возрастом и ультразвуковыми показателями диафрагмы. Найдены слабые статистически значимые связи между структурно-функциональным состоянием диафрагмы и антропометрическими характеристиками обследованных: массой тела и индексом массы тела. ВЫВОДЫ: Ультразвуковые показатели работы диафрагмы не коррелируют или плохо коррелируют со спирометрическими. У здоровых лиц нет оснований использовать ультразвуковое исследование диафрагмы, так как оно практически не дает дополнительной информации о состоянии аппарата внешнего дыхания

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

© 2016, Springer Science+Business Media New York.An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo

ASSOCIATION BETWEEN CLINICAL MANIFESTATIONS AND ULTRASONIC SIGNS OF INFLAMMATION IN PATIENTS WITH RHEUMATOID ARTHRITIS

Rheumatoid arthritis (RA) is a systemic autoimmune rheumatic disease characterized by chronic inflammation of the synovial membrane and a wide range of extra-articular (systemic) manifestations. The main goal of RA therapy is to achieve low disease activity or clinical remission. Power Doppler (PD) ultrasonography (USG) can significantly distinguish between active synovitis (hypervascularization of the synovial membrane) and inactive synovial proliferation.Objective: to investigate the association between the ultrasonic signs of active inflammation and the clinical and laboratory parameters of disease activity in patients with RA.Subjects and methods. The investigation included RA patients followed up at the V.A. Nasonova Research Institute of Rheumatology within the first Russian strategic study of pharmacotherapy for RA – REMARCA (Russian invEstigation of MethotrexAte and biologicals for eaRly aCtive Arthritis). A total of 105 RA patients (mean age 51 years), among whom 80% were rheumatoid factor (RF)-positive and 75% were anti-cyclic citrullinated peptide (ACCP)-positive, were examined. In all the patients, methotrexate (metoject, MEDAC, Germany) as the first diseasemodifying anti-rheumatic drug was subcutaneously injected in an initial dose of 10 mg/week with its rapid escalation up to 20–25 mg/week. Then the therapy was added by biologicals as the need arose. The clinical and laboratory parameters were analyzed immediately before and then 12, 24, 36, and 48 weeks following treatment. Therapeutic efficacy was evaluated using the European League Against Rheumatism (EULAR) criteria and activity indices (DAS28, CDAI, and SDAI). USG of eight articular areas (the wrist, second and third metacarpophalangeal, second and third proximal interphalangeal, second and fifth metatarsophalangeal articulations) in the hand and foot of the clinically dominant side was carried out in all the patients prior to treatment and at 12, 24, 36, and 48 weeks after its initiation. Semiquantitative gray-scale (GS) assessment and PD USG were performed according to the OMERACT criteria.Results and discussion. Weak correlations were found between USG parameters and DAS28, SDAI, and CDAI. After 48-week therapy, the signs of active synovitis were absent in 54 patients and persisted in 51, as evidenced by PD USG. The differences in clinical, laboratory, and ultrasonic parameters were analyzed in relation to USG evidence for active inflammation following 48 weeks of treatment. There were significant differences in GS and PD scores throughout the follow-up period; there were also differences in C-reactive protein levels at 12 and 48 weeks of therapy. No differences were found in clinical activity indices.Conclusion. The investigation provides support for the important role of USG in assessing the activity of synovitis in RA

Numerical Model of the Motion of Artificial Earth Satellite Systems. Latest Version

В работе представлено описание последней версии численной модели движения систем искусственных спутников Земли (ИСЗ), разработанной в НИИ ПММ ТГУ. Представленное программное математическое обеспечение (ПМО) позволяет прогнозировать движение ИСЗ, исследовать хаотичность движения околоземных объектов, вычислять резонансные характеристики для изучения влияния вековых резонансов на динамику ИСЗ. Программный комплекс реализован в двух версиях: для персонального компьютера (ПК) и в среде параллельных вычислений «СКИФ Cyberia» ТГУ. Для удобства ПМО дополнено пользовательским интерфейсом.The paper presents a description of the latest version of the numerical model of the motion of artificial Earth satellites (AES) systems developed at the Research Institute of Applied Mathematics and Mechanics of Tomsk State University. The presented mathematical software (MO) makes it possible to predict the motion of the satellite, to investigate the chaotic character of the motion of AES, to calculate resonant characteristics to study the influence of secular resonances on the dynamics of the satellite. The software package is realized in two versions: for a personal computer and in the environment of parallel computing “SKIF Cyberia” TSU. For convenience, the MO is supplemented with a user interface.Исследование выполнено за счет гранта Российского научного фонда № 19-72-10022, https://rscf.ru/project/19-72-10022/

Value of ultrasound indices for the assessment of rheumatoid arthritis activity and tocilizumab therapy efficiency

Objective: to estimate the value of simplified ultrasound (US) indices of synovitis in the most commonly involved joints of the dominant hand, which are studied using the grey scale mode while monitoring the efficiency of tocilizumab (TCZ) therapy in patients with rheumatoid arthritis (RA). Subjects and methods. Forty-six patients with RA confirmed by the 1987 American College of Rheumatology (ACR) criteria who had been ineffectively treated received TCZ infusions for 6 months. The patients were stratified into two groups: 1) 11 patients with early (<2-year) RA (ERA); 2) 35 patients with protracted (>2-year) RA (PRA). Disease activity and therapy efficiency were determined by DAS28-CRP, SDAI, and US study of the dominant hand joints most commonly involved in the pathological process. Results. The evaluation of TCZ therapy from the simplified US indices reflected synovitis regression in the dominant hand joints of patients with ERA. The highly significant correlations between the changes in US parameters and RA activity the indices ^US-wrist/iDAS28-CRP: r = 0.75; p = 0.01; ΔUS-S8/ΔDAS28-CRP and ΔUS-S5/ΔSDAI: r = 0.65; p < 0.05) confirm the validity of the above changes. No reduction in the joint indices was observed in the patients with PRA. Conclusion. The simplified grey-scale US indices of synovitis in the joints of the dominant hand (including one wrist joint) is an accessible noninvasive method for evaluating the efficiency of the therapy performed in patients with ERA

EVALUATION OF THE EFFICIENCY OF TOCILIZUMAB THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS BY ULTRASOUND AND X-RAY DATA

Objective: to estimate the time course of changes in the ultrasound signs of wrist joint synovitis in patients with rheumatoid arthritis (RA) during tocilizumab (TCZ) treatment and to determine whether the progression of joint X-ray changes can be predicted by ultrasonography (USG). Subjects and methods. The investigation enrolled 46 patients with the diagnosis of RA that met the American College of Rheumatology 1987 criteria. All the patients were given TCZ during insufficiently effective previous therapy (median DAS28 was 6.7 [range 5.9—7.2]). They were divided into 2 groups: 1) early RA (ERA) with a disease history of less than 2 years (n = 11); 2) RA with a history of over 2 years (n = 35). Hand USG (Voluson-i GE, USA) with a 4—13-MHz linear probe using an energy Doppler (ED) was carried out before and 6 months after therapy. Structural changes were evaluated by hand and foot X-ray study (before and at 12-month follow-up) according to the Sharp method modified by van der Heide. Results. Dynamic evaluation of the ultrasound signs of inflammation indicated a significant reduction in the magnitude of synovitis in accordance with the gray-scale data in both groups and only in the patients with ERA in the ED mode. There was a clear association of the annual increment in joint X-ray changes with the result of estimation of the magnitude of synovitis according to the ED data (r = 0.669; p < 0.01). Conclusion. Wrist joint sonography allows evaluation of the efficiency of the performed therapy in patients with RA and the presence of moderate or severe synovitis, as evidenced by ED, is a predictor for the progression of joint destruction