A Comparison of Depression and Anxiety among University Students in Nine Countries during the COVID-19 Pandemic.

The mental health of young adults, particularly students, is at high risk during the COVID-19 pandemic. The purpose of this studywas to examine differences inmental health between university students in nine countries during the pandemic. The study encompassed 2349 university students (69% female) from Colombia, the Czech Republic (Czechia), Germany, Israel, Poland, Russia, Slovenia, Turkey, and Ukraine. Participants underwent the following tests: Patient Health Questionnaire (PHQ-8), Generalized Anxiety Disorder (GAD-7), Exposure to COVID-19 (EC-19), Perceived Impact of Coronavirus (PIC) on students’ well-being, PhysicalActivity (PA), andGeneral Self-ReportedHealth (GSRH). The one-wayANOVAshowed significant differences between countries. The highest depression and anxiety risk occurred in Turkey, the lowest depression in the Czech Republic and the lowest anxiety in Germany. The 2 independence test showed that EC-19, PIC, and GSRHwere associatedwith anxiety and depression inmost of the countries, whereas PA was associated in less than half of the countries. Logistic regression showed distinct risk factors for each country. Gender and EC-19 were the most frequent predictors of depression and anxiety across the countries. The role of gender and PA for depression and anxiety is not universal and depends on cross-cultural differences. Students’mental health should be addressed froma cross-cultural perspective

Development and Validation of the Test of Orthorexia Nervosa (TON-17)

This study aims to develop and validate a new self-report questionnaire to measure orthorexia nervosa (ON). Based on a current review of the scientific literature and interviews with people at risk of orthorexia, 40 items were selected to test orthorexia nervosa (TON-40). A total sample of 767 individuals (M = 26.49, SD = 9.66, 56.98% women) participated in the study. The exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and composite construct analysis (CCA) were performed to find an appropriate model of sufficient reliability and validity and stable construction. Convergent validation was performed regarding the correlation of the TON-17 with another measure of ON (ORTO-15), eating disorders (the EAT-26 and DEAS), healthy behavior (the HBI), quality of life (the Brief WHOQOL), physical health (the GRSH), anxiety (the GAD-7), depression (the PHQ-9), and obsessive-compulsive disorder (the OCI-R). Gender, Body Mass Index (BMI), and the medical reasons for a restrictive diet were also examined. As a result of the structural analyses, the number of items was reduced from 40 to 17. The best fit indices of the TON-17 were found for the hierarchical bi-factor model, with three lower-order factors (Control of food quality, Fixation of health and healthy diet, and Disorder symptoms) and one general higher-order factor (Orthorexia). According to the 95th percentile method of estimation, the prevalence of ON was 5.5% for the TON-17 total score. The TON-17 scale and subscales showed good psychometric properties, stability, reliability, and construct validity. The TON-17 indicated a positive relationship with the ORTO-15, EAT-26, DEAS, HBI, OCI-R, GAD-7, and PHQ-9. TON-17 can be considered as a useful tool for assessing the risk of ON

Estrogen-related receptor alpha : an orphan finds a family

Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy

Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

Abstract Background Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis. To further understand IGF1R signaling we have investigated the involvement of the oncogenic IGF1R-related sphingosine kinase (SphK) pathway. Methods The prognostic (overall survival, OS) and therapeutic (anti-endocrine therapy) co-contribution of IGF1R and SphK1 were investigated using breast cancer patient samples (n = 236) for immunohistochemistry to measure total and phosphorylated IGF1R and SphK1. Kaplan-Meier and correlation analyses were performed to determine the contribution of high versus low IGF1R and/or SphK1 expression to OS in patients treated with anti-endocrine therapy. Cell viability and colony formation in vitro studies were completed using estrogen receptor (ER) positive and negative breast cancer cell-lines to determine the benefit of IGF1R inhibitor (OSI-906) and SphK inhibitor (SKI-II) co-therapy. Repeated measures and 1-way ANOVA were performed to compare drug treatments groups and the Chou-Talalay combination index (CI) was calculated to estimate drug synergism in vitro (CI < 1). Results High IGF1R and SphK1 protein co-expression in tumor tissue was associated with improved OS specifically in ER-positive disease and stratified for anti-endocrine therapy. A significant synergistic inhibition of cell viability and/or colony formation following OSI-906 and SKI-II co-treatment in vitro was evident (p < 0.05, CI < 1). Conclusion We conclude that high IGF1R and SphK1 co-expression act together as prognostic indicators and are potentially, dual therapeutic targets for the development of a more effective IGF1R-directed combination breast cancer therapy

Longitudinal Predictors of Coronavirus-Related PTSD among Young Adults from Poland, Germany, Slovenia, and Israel

The aim of this study was to reveal longitudinal predictors of coronavirus-related PTSD and the moderating roles of country, sex, age, and student status among young adults from Poland, Germany, Slovenia, and Israel. We included the following predictors: perceived stress, exposure to COVID-19, perceived impact of COVID-19 on well-being in socioeconomic status (PNIC-SES) and social relationships (PNIC-SR), fear of COVID-19, fear of vaccination, and trust in institutions. We conducted the study online among a representative sample of 1723 young adults aged 20&ndash;40 (M = 30.74, SD = 5.74) years in February 2021 (T1) and May&ndash;June 2021 (T2). We used McNemar&rsquo;s &chi;2 and the paired samples Student&rsquo;s t-test to test differences over time. We assessed the relationships between variables using Pearson&rsquo;s correlation. We performed structural equation modeling (SEM) to examine the associations between variables at T1 and T2. We used a lagged regression model to examine the causal influences between variables across different time points (T1 and T2). The results showed that all variables decreased over time, except exposure to COVID-19. The rates of infected, tested, and under-quarantine participants increased. The rates of those who lost a job and experienced worsening economic status decreased. The rate of hospitalized participants and those experiencing the loss of close ones did not change. Higher perceived stress, fear of COVID-19, fear of vaccination, and trust in institutions were significant longitudinal predictors of coronavirus-related PTSD regardless of country, sex, age, and student status. Institutions should provide more accurate programs for public health, so trust in institutions can be a protective and not a risk factor in future traumatic events

Can Fear of COVID-19 Be Predicted by Religiosity and Trust in Institutions among Young Adults? A Prospective Cross-National Study

The aim of this study was to reveal whether religiosity and trust in institutions are longitudinal predictors of change in fear of COVID-19 (FCV-19) across Poland, Germany, Slovenia, and Israel among young adults over a three-month period. The representative sample consisted of 1723 participants between the ages of 20 and 40 years (M = 30.74, SD = 5.74) across Poland (n = 446), Germany (n = 418), Slovenia (n = 431), and Israel (n = 428). The first measurement was carried out in February 2020 and the second was conducted in May/June 2020. A repeated-measures, two-way, mixed-factor ANOVA was performed to examine changes over time (T) and across countries (C) as well as the interaction of time and country (TxC) for FCV-19, religiosity, and trust in institutions. The results showed a significant decrease over time and differences between countries in all variables, as well as in TxC for FCV-19 and trust in institutions. Linear generalized estimating equations (GEEs) were used to assess the longitudinal change between T1 and T2 in FCV-19, including religiosity and trust in institutions as predictors, country as a factor, and gender and age as confounders. Female gender, religiosity, and trust in institutions were found to be significant longitudinal predictors of change in FCV-19. Country was a significant moderator of the relationship between trust in institutions and FCV-19, with the highest result achieved in Poland. Religiosity and trust in institutions were positive predictors of change in fear of COVID-19 among young adults across countries. Religious and governmental institutions should take this into consideration when communicating with believers and citizens during challenging situations

Validation of the Brief Perceived Positive Lockdown Impact Scale PPLIS-4

Background: Although research showed that positive aspects of the lockdown were perceived during the pandemic, there are no tools to test the positive impact of mandatory social isolation on life. The present study aims to validate a newly developed, brief, four-item perceived positive lockdown impact scale (PPLIS-4). Methods: A cross-sectional online survey study was formed among 4370 adults in three samples: Sample 1 consisted of university students from Poland and Ukraine, Sample 2 consisted of Polish university students under 26 (emerging adults), and Sample 3 consisted of Polish and Ukrainian adults above 25 (non-emerging adults). The standardized questionnaire was used for criterion validity to measure life satisfaction (SWLS), perceived stress (PSS-10), anxiety (GAD-7), and depression (PHQ-9). Results: The exploratory factor analysis (EFA) showed a one-factor solution in Sample 1 in Polish and Ukrainian university students. The confirmatory factor analysis (CFA) and confirmatory composite analysis (CCA) showed the one-factor structure appropriate for the PPLIS-4 among emerging and non-emerging adults. Criterion validity was also confirmed since the PPLIS-4 was positively related to the SWLS and negatively related to stress, anxiety, and depression. Conclusions: The PPLIS-4 is a short but valid questionnaire to assess the positive aspects of lockdown. The PPLIS-4 can be used during the COVID-19 pandemic to measure some positive effects of changes in lifestyle as an aspect of resilience

Changes in Mental Health during the COVID-19 Pandemic among Representative Sample of Young Adults from Germany, Israel, Poland, and Slovenia: A Longitudinal Study

The aim of this cross-national longitudinal study was to identify a change in mental health indicators: coronavirus-related post-traumatic stress disorder (PTSD), perceived stress, and fear of vaccination (FoVac). The first measurement (T1) took place in February 2021, and the second (T2) took place in May&ndash;June 2021. The sample consisted of 1723 participants across Germany, Israel, Poland, and Slovenia, between the age of 20 and 40 (M = 30.74, SD = 5.74). A paired-samples Student&rsquo;s t-test was used for testing the differences between T1 and T2. A repeated measures two-way ANOVA was performed to examine changes over time (T) and across the countries (C). A significant although small decrease at T2 was found for coronavirus-related PTSD, perceived stress, and FoVac. A significant main effect was found for T, C, and TxC for all variables, except the interaction effect for coronavirus-related PTSD and perceived stress. A medium effect size was found for coronavirus-related PTSD and FoVac across countries as well as perceived stress over time. A small effect size was revealed for coronavirus-related PTSD and FoVac over time, perceived stress across countries, and interaction for FoVac. A significant improvement in mental health was demonstrated across the four countries (particularly in Israel); however, there were still differences among each of them. Therefore, the cross-national context should be taken into consideration when analyzing the effects of the COVID-19 pandemic on mental health

A Comparison of Depression and Anxiety among University Students in Nine Countries during the COVID-19 Pandemic

La salud mental de los adultos jóvenes, particularmente los estudiantes, está en alto riesgo durante la pandemia de COVID-19 pandemia. El propósito de este estudio fue examinar las diferencias en salud mental entre estudiantes universitarios en nueve países durante la pandemia. El estudio abarcó a 2349 estudiantes universitarios (69% mujeres) de Colombia, República Checa (Chequia), Alemania, Israel, Polonia, Rusia, Eslovenia, Turquía y Ucrania. Los participantes se sometieron a las siguientes pruebas: Cuestionario de Salud del Paciente (PHQ-8), Ansiedad Generalizada (GAD-7), Exposición a COVID-19 (EC-19), Impacto percibido del coronavirus (PIC) en los estudiantes bienestar, actividad física (PA) y salud general autoinformada (GSRH). El ANOVA de una vía mostró diferencias significativas entre países. El mayor riesgo de depresión y ansiedad ocurrió en Turquía, el depresión más baja en la República Checa y la ansiedad más baja en Alemania. El χ 2 prueba de independencia mostró que EC-19, PIC y GSRH se asociaron con ansiedad y depresión en la mayoría de los países, mientras que la AP se asoció en menos de la mitad de los países. La regresión logística mostró distintos factores de riesgo para cada país. El sexo y el EC-19 fueron los predictores más frecuentes de depresión y ansiedad en los países. El papel del género y la AF para la depresión y la ansiedad no es universal y depende de diferencias transculturales. La salud mental de los estudiantes debe abordarse desde una perspectiva intercultural.The mental health of young adults, particularly students, is at high risk during the COVID-19 pandemic. The purpose of this study was to examine differences in mental health between university students in nine countries during the pandemic. The study encompassed 2349 university students (69% female) from Colombia, the Czech Republic (Czechia), Germany, Israel, Poland, Russia, Slovenia, Turkey, and Ukraine. Participants underwent the following tests: Patient Health Questionnaire (PHQ-8), Generalized Anxiety Disorder (GAD-7), Exposure to COVID-19 (EC-19), Perceived Impact of Coronavirus (PIC) on students’ well-being, Physical Activity (PA), and General Self-Reported Health (GSRH). The one-way ANOVA showed significant differences between countries. The highest depression and anxiety risk occurred in Turkey, the lowest depression in the Czech Republic and the lowest anxiety in Germany. The χ 2 independence test showed that EC-19, PIC, and GSRH were associated with anxiety and depression in most of the countries, whereas PA was associated in less than half of the countries. Logistic regression showed distinct risk factors for each country. Gender and EC-19 were the most frequent predictors of depression and anxiety across the countries. The role of gender and PA for depression and anxiety is not universal and depends on cross-cultural differences. Students’ mental health should be addressed from a cross-cultural perspective

Does Physical Activity Matter for the Mental Health of University Students during the COVID-19 Pandemic?

Research indicates that university and college students are at higher risk of experiencing mental health problems than other populations. This study aims to examine the relationship between Physical Activity (PA) and the mental health of Ukrainian university students during the Corona Virus Disease 2019 (COVID-19) pandemic lockdown. The conventional sample consisted of 1512 students from 11 Ukrainian universities, with a mean age of 20 years (M = 20.06, SD = 3.05) and 69% of whom were female. The cross-sectional online survey was disseminated through the most popular social media channels in Ukraine (i.e., Facebook, Viber, Telegram) and included the Generalized Anxiety Disorder (GAD-7) scale to measure anxiety and the Patient Health Questionnaire (PHQ-9) to assess depression. Data were collected from 14 May to 4 June 2020 during the COVID-19 pandemic outbreak in Ukraine. Among university students, 43% were engaged in PA &ge; 150 min weekly, 24% met the criteria of GAD, and 32% met the criteria of depression. More students were involved in PA before the COVID-19 outbreak than during the national lockdown. Students with anxiety and depression were almost two times less likely to engage in PA than their counterparts without mental health disorders. The inactive group had higher scores of anxiety and depression than the physically active group. The relationship of PA with anxiety and depression was statistically significant but weak during the COVID-19 pandemic