Multiple binomial logistic regression analysis to predict 30-day mortality.

<p>Patients with serum MDA higher than 2.27 nmol/mL (n = 23) presented higher 30-day mortality (Hazard ratio = 2.9; 95% CI = 1.31–6.33; p = 0.005) than patients with lower levels (n = 27) in the survival analysis (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125893#pone.0125893.g003" target="_blank">Fig 3</a>).</p><p>Multiple binomial logistic regression analysis to predict 30-day mortality.</p

Receiver operation characteristic analysis using serum malondialdehyde levels as predictor of mortality at 30 days.

<p>Receiver operation characteristic analysis using serum malondialdehyde levels as predictor of mortality at 30 days.</p

Serum malondialdehyde levels in severe malignant middle cerebral artery infarction patients and healthy controls.

<p>Serum malondialdehyde levels in severe malignant middle cerebral artery infarction patients and healthy controls.</p

Clinical and biochemical characteristics of 30-day survivor and non-survivor MMCAI patients.

<p>P 25–75 = percentile 25^th-75^th; APACHE II = Acute Physiology and Chronic Health Evaluation; aPTT = activated partial thromboplastin time; GCS = Glasgow Coma Scale; INR = international normalized ratio; PaO₂ = pressure of arterial oxygen/fraction inspired oxygen; FIO₂ = pressure of arterial oxygen/fraction inspired oxygen; MDA = Malondialdehyde</p><p>Clinical and biochemical characteristics of 30-day survivor and non-survivor MMCAI patients.</p

Characteristics of healthy controls and patients with severe malignant middle cerebral artery infarction.

<p>Characteristics of healthy controls and patients with severe malignant middle cerebral artery infarction.</p

Characteristics of severe septic patients according to genotype in the PAI-1 gene.

<p>COPD = chronic obstructive pulmonary disease; PaO₂/FIO₂ = pressure of arterial oxygen/fraction inspired oxygen; INR = International normalized ratio aPTT = Activated partial thromboplastin time; APACHE = Acute Physiology and Chronic Health Evaluation; SOFA = Sepsis-related Organ Failure Assessment.</p><p>Characteristics of severe septic patients according to genotype in the PAI-1 gene.</p

Kaplan-Meier curves showing the cumulative proportion of survival patients at 30 days and 6 months according to the presence of 4G/4G vs other genotypes of PAI-1 genetic polymorphism.

<p>Kaplan-Meier curves showing the cumulative proportion of survival patients at 30 days and 6 months according to the presence of 4G/4G vs other genotypes of PAI-1 genetic polymorphism.</p

Early and late mortality according to genotype in the PAI-1 genetis polymorphis.

<p>Early and late mortality according to genotype in the PAI-1 genetis polymorphis.</p

Correlation of serum caspase-cleaved citokeratin (CCCK)-18 levels with serum levels of TNF-α, interleukin-6, interleukin-10, and lactic acid, and with SOFA and APACHE-II scores.

<p>TNF = tumor necrosis factor; SOFA = Sepsis-related Organ Failure Assessment score<b>;</b> APACHE = Acute Physiology and Chronic Health Evaluation (APACHE)-II score; rho = Spearman’s rank correlation coefficient.</p><p>Correlation of serum caspase-cleaved citokeratin (CCCK)-18 levels with serum levels of TNF-α, interleukin-6, interleukin-10, and lactic acid, and with SOFA and APACHE-II scores.</p

Multiple logistic regression analyses to predict 6-month mortality.

<p>Multiple logistic regression analyses to predict 6-month mortality.</p