1 research outputs found
Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors
A forward chemical genetic approach
was followed to discover new
targets and lead compounds for Parkinson’s disease (PD) treatment.
By analysis of the cell protection produced by some small molecules,
a diphenyl sulfide compound was revealed to be a new phosphodiesterase
7 (PDE7) inhibitor and identified as a new hit. This result allows
us to confirm the utility of PDE7 inhibitors as a potential pharmacological
treatment of PD. On the basis of these data, a diverse family of diphenyl
sulfides has been developed and pharmacologically evaluated in the
present work. Moreover, to gain insight into the safety of PDE7 inhibitors
for human chronic treatment, we evaluated the new compounds in a surrogate
emesis model, showing nonemetic effects