1 research outputs found
Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher
The
near-infrared fluorescent activatable smart probe Pyro-phosphatidylethanolamine
(PtdEtn)-QSY was synthesized and observed to selectively fluoresce
in the presence of phosphatidylcholine-specific phospholipase C (PC-PLC).
PC-PLC is an important biological target as it is known to be upregulated
in a variety of cancers, including triple negative breast cancer.
Pyro-PtdEtn-QSY features a QSY21 quenching moiety instead of the Black
Hole Quencher-3 (BHQ-3) used previously because the latter contains
an azo bond, which could lead to biological instability