2 research outputs found
Primary spinal cord tumors of childhood: effects of clinical presentation, radiographic features, and pathology on survival
To determine the relationship between clinical presentation, radiographic features, pathology, and treatment on overall survival of newly diagnosed pediatric primary spinal cord tumors (PSCT). Retrospective analysis of all previously healthy children with newly diagnosed PSCT at a single institution from 1995 to present was performed. Twenty-five pediatric patients (15 boys, average 7.9Â years) were diagnosed with PSCT. Presenting symptoms ranged from 0.25 to 60Â months (average 7.8Â months). Symptom duration was significantly shorter for high grade tumors (average 1.65Â months) than low grade tumors (average 11.2Â months) (PÂ =Â 0.05). MRI revealed tumor (8 cervical, 17 thoracic, 7 lumbar, 7 sacral) volumes of 98â94,080Â mm3 (average 19,474Â mm3). Homogeneous gadolinium enhancement on MRI correlated with lower grade pathology (PÂ =Â 0.003). There was no correlation between tumor grade and volume (PÂ =Â 0.63) or edema (PÂ =Â 0.36) by MRI analysis. Median survival was 53Â months and was dependent on tumor grade (PÂ =Â 0.05) and gross total resection (PÂ =Â 0.01) but not on gender (PÂ =Â 0.49), age of presentation (PÂ =Â 0.82), duration of presenting symptoms (PÂ =Â 0.33), or adjuvant therapies (PÂ =Â 0.17). Stratified KaplanâMeier analysis confirmed the association between degree of resection and survival after controlling for tumor grade (PÂ =Â 0.01). MRI homogeneous gadolinium enhancement patterns may be helpful in distinguishing low grade from high grade spinal cord malignancies. While tumor grade and gross total resection rather than duration of symptoms correlated with survival in our series, greater than one-third of patients had reported symptoms greater than 6Â months duration prior to diagnosis
Recommended from our members
Primary spinal cord tumors of childhood: effects of clinical presentation, radiographic features, and pathology on survival
To determine the relationship between clinical presentation, radiographic features, pathology, and treatment on overall survival of newly diagnosed pediatric primary spinal cord tumors (PSCT). Retrospective analysis of all previously healthy children with newly diagnosed PSCT at a single institution from 1995 to present was performed. Twenty-five pediatric patients (15 boys, average 7.9Â years) were diagnosed with PSCT. Presenting symptoms ranged from 0.25 to 60Â months (average 7.8Â months). Symptom duration was significantly shorter for high grade tumors (average 1.65Â months) than low grade tumors (average 11.2Â months) (PÂ =Â 0.05). MRI revealed tumor (8 cervical, 17 thoracic, 7 lumbar, 7 sacral) volumes of 98â94,080Â mm3 (average 19,474Â mm3). Homogeneous gadolinium enhancement on MRI correlated with lower grade pathology (PÂ =Â 0.003). There was no correlation between tumor grade and volume (PÂ =Â 0.63) or edema (PÂ =Â 0.36) by MRI analysis. Median survival was 53Â months and was dependent on tumor grade (PÂ =Â 0.05) and gross total resection (PÂ =Â 0.01) but not on gender (PÂ =Â 0.49), age of presentation (PÂ =Â 0.82), duration of presenting symptoms (PÂ =Â 0.33), or adjuvant therapies (PÂ =Â 0.17). Stratified KaplanâMeier analysis confirmed the association between degree of resection and survival after controlling for tumor grade (PÂ =Â 0.01). MRI homogeneous gadolinium enhancement patterns may be helpful in distinguishing low grade from high grade spinal cord malignancies. While tumor grade and gross total resection rather than duration of symptoms correlated with survival in our series, greater than one-third of patients had reported symptoms greater than 6Â months duration prior to diagnosis