Gestión de deportistas extremos

Se diseñó y desarrolló un sistema de localización de deportistas de montaña para abreviar la relación espacio-temporal en caso de accidentes, búsqueda, acciones de control, entre otras situaciones. Es una herramienta innovadora factible de implementarse utilizando la interconexión de redes inalámbricas e Internet. Consiste en un dispositivo portable con un GPS y un módulo Zigbee, que transmite la posición a través de una red de nodos a la estación receptora en la base de operaciones. Alli se interconecta la red de radio con Internet a traves de un gateway, que se encarga de reenviar los datos a una plataforma integral de gestión alojada en un servidor web. El aspecto global del sistema está dado por la plataforma, ya que al estar “en la nube”, permite el acceso virtual desde cualquier dispositivo que tenga conexión a Internet, para poder visualizar la información disponible asignada a cada usuario de la plataforma

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision

Abstract Irreversible photoreceptor cell death is a major cause of blindness in many retinal dystrophies. A better understanding of the molecular mechanisms underlying the progressive loss of photoreceptor cells remains therefore crucial. Abnormal expression of microRNAs (miRNAs) has been linked with the aetiology of a number of retinal dystrophies. However, their role during the degenerative process remains poorly understood. Loss of cone photoreceptors in the human macula has the greatest impact on sight as these cells provide high acuity vision. Using a Chrnb4-cre; Dicer flox/flox conditional knockout mouse (Dicer CKO) to delete Dicer1 from cone cells, we show that cone photoreceptor cells degenerate and die in the Dicer-deleted retina. Embryonic eye morphogenesis appeared normal in Dicer CKO mice. Cone photoreceptor abnormalities were apparent by 3 weeks of age, displaying either very short or absent outer segments. By 4 months 50% of cones were lost and cone function was impaired as assessed by electroretinography (ERG). RNAseq analysis of the Dicer CKO retina revealed altered expression of genes involved in the visual perception pathway. These data show that loss of Dicer1 leads to early-onset cone cell degeneration and suggest that Dicer1 is essential for cone photoreceptor survival and homeostasis