Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women

OBJECTIVE: Serum uric acid (SUA) is associated with cardiovascular disease (CVD). However it is still disputed whether the relationship is mediated by other risk factors such as obesity, dyslipidaemia, hypertension and insulin resistance. We explored the association of the uric acid level with carotid intima-media thickness (IMT), a well known marker of CVD, in postmenopausal healthy women. METHODS: We consecutively enrolled postmenopausal women undergoing a screening for health evaluation. After an accurate clinical examination, and a biochemical evaluation, the enrolled subjects underwent B mode ultrasonography to assess common carotid intima media thickness. RESULTS: Among 234 women aged 45-70 years, the uric acid level is associated with carotid IMT independently of other prognostic factors (p=0.03). In particular, women in the highest tertiles of uric acid level have a greater IMT than women in the lowest tertile (p=0.007). CONCLUSIONS: Independently of other cardiovascular risk factors, SUA levels are associated with carotid IMT even in subjects without the metabolic syndrome. This confirms and expands the role of uric acid in the determinism of CVD. Prospective trials would be useful to evaluate interventions aimed at lowering the uric acid level

Posted: The Campaign Sign Landscape, Race, and Political Participation in Mississippi

Cultural landscapes offer potential insights into cultural processes. As a cultural/political landscape element, the domestic campaign sign is linked to a variety of socio-cultural and political processes. Examination of the geographical distribution of 2004 presidential election campaign signs posted throughout the town of Hattiesburg, Mississippi, illustrates that race is a factor in understanding who chooses to post signs. Historically, limitations on political participation in the South would have included use of landscape for communication, imposing a sort of metacommunicative landscape hegemony. Further, patterns of sign postings and voter turnout indicate that both activities are forms of political participation that are embraced differently by different social groups