Salivary Metabolomic Signatures and Body Mass Index in Italian Adolescents: A Pilot Study

Context: Obesity surveillance is scarce in adolescents, and little is known on whether salivary metabolomics data, emerging minimally invasive biomarkers, can characterize metabolic patterns associated with overweight or obesity in adolescents. Objective: This pilot study aims to identify the salivary molecular signatures associated with body mass index (BMI) in Italian adolescents. Methods: Saliva samples and BMI were collected in a subset of n = 74 young adolescents enrolled in the Public Health Impact of Metal Exposure study (2007-2014). A total of 217 untargeted metabolites were identified using liquid chromatography-high resolution mass spectrometry. Robust linear regression was used to cross-sectionally determine associations between metabolomic signatures and sex-specific BMI-for-age z-scores (z-BMI). Results: Nearly 35% of the adolescents (median age: 12 years; 51% females) were either obese or overweight. A higher z-BMI was observed in males compared to females (P = .02). One nucleoside (deoxyadenosine) and 2 lipids (18:0-18:2 phosphatidylcholine and dipalmitoyl-phosphoethanolamine) were negatively related to z-BMI (P < .05), whereas 2 benzenoids (3-hydroxyanthranilic acid and a phthalate metabolite) were positively associated with z-BMI (P < .05). In males, several metabolites including deoxyadenosine, as well as deoxycarnitine, hyodeoxycholic acid, N-methylglutamic acid, bisphenol P, and trigonelline were downregulated, while 3 metabolites (3-hydroxyanthranilic acid, theobromine/theophylline/paraxanthine, and alanine) were upregulated in relation to z-BMI (P < .05). In females, deoxyadenosine and dipalmitoyl-phosphoethanolamine were negatively associated with z-BMI while deoxycarnitine and a phthalate metabolite were positively associated (P < .05). A single energy-related pathway was enriched in the identified associations in females (carnitine synthesis, P = .04). Conclusion: Salivary metabolites involved in nucleotide, lipid, and energy metabolism were primarily altered in relation to BMI in adolescents

The Asymptotic Number of Attractors in the Random Map Model

The random map model is a deterministic dynamical system in a finite phase space with n points. The map that establishes the dynamics of the system is constructed by randomly choosing, for every point, another one as being its image. We derive here explicit formulas for the statistical distribution of the number of attractors in the system. As in related results, the number of operations involved by our formulas increases exponentially with n; therefore, they are not directly applicable to study the behavior of systems where n is large. However, our formulas lend themselves to derive useful asymptotic expressions, as we show.Comment: 16 pages, 1 figure. Minor changes. To be published in Journal of Physics A: Mathematical and Genera

Schumpeterian economic dynamics as a quantifiable minimum model of evolution

We propose a simple quantitative model of Schumpeterian economic dynamics. New goods and services are endogenously produced through combinations of existing goods. As soon as new goods enter the market they may compete against already existing goods, in other words new products can have destructive effects on existing goods. As a result of this competition mechanism existing goods may be driven out from the market - often causing cascades of secondary defects (Schumpeterian gales of destruction). The model leads to a generic dynamics characterized by phases of relative economic stability followed by phases of massive restructuring of markets - which could be interpreted as Schumpeterian business `cycles'. Model timeseries of product diversity and productivity reproduce several stylized facts of economics timeseries on long timescales such as GDP or business failures, including non-Gaussian fat tailed distributions, volatility clustering etc. The model is phrased in an open, non-equilibrium setup which can be understood as a self organized critical system. Its diversity dynamics can be understood by the time-varying topology of the active production networks.Comment: 21 pages, 11 figure

Spin and magnetization effects in plasmas

We give a short review of a number of different models for treating magnetization effects in plasmas. In particular, the transition between kinetic models and fluid models is discussed. We also give examples of applications of such theories. Some future aspects are discussed.Comment: 18 pages, 1 figure. To appear in Plasma Physics and Controlled Fusion, Special Issue for the 37th ICPP, Santiago, Chil

Transferring orbital and spin angular momenta of light to atoms

Light beams carrying orbital angular momentum, such as Laguerre-Gaussian beams, give rise to the violation of the standard dipolar selection rules during the interaction with matter yielding, in general, an exchange of angular momentum larger than hbar per absorbed photon. By means of ab initio 3D numerical simulations, we investigate in detail the interaction of a hydrogen atom with intense Gaussian and Laguerre-Gaussian light pulses. We analyze the dependence of the angular momentum exchange with the polarization, the orbital angular momentum, and the carrier-envelope phase of light, as well as with the relative position between the atom and the light vortex. In addition, a quantum-trajectory approach based on the de Broglie-Bohm formulation of quantum mechanics is used to gain physical insight into the absorption of angular momentum by the hydrogen atom