Kualitas Pelayanan Rekomendasi Penelitian Bagi Mahasiswa Strata Satu (S-1) di Badan Pelayanan Perizinan Terpadu (Bp2t) Provinsi Riau

Services provided by the Integrated Licensing Service Agency Riau Province to the applicant on the research must be in accordance with the general principles of public service so as to provide a quality service. Recommendations Research Services Licensing Service Agency Riau Province can be said of quality for Integrated Licensing Service Agency Riau Province has been providing services in accordance with the principle of service so as to get various public service achievements. The facilities provided by the Integrated Licensing Service Agency Riau Province adequate and have employees who have the ability to use the facilities available. Employees respond to any request for the public and can provide certainty of time in completing the application for the community. Then employees are always friendly and courteous in serving the community. The purpose of this study was to analyze the quality of services in the research recommendations Licensing Service Agency Riau Province and determine the factors that influence it. The results of this study indicate that the Integrated Licensing Service Agency Riau Province has a good quality service in serving the community and in accordance with the expectations and needs of the community. Starting from owned facilities are complete, the precision in serving the community, provide guarantees ketepan time in completing the work, expertise in using facilities owned, non-discriminatory, have a good response to the people who need help and serve the people in a friendly manner. Factors - factors that affect the quality of services in the research recommendations Licensing Service Agency Riau Province is infrastructure, human resources and leadership.Keywords: Quality of Service, Recommendation Research, Licensing Service Agency Riau Provinc

Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study

<p>Abstract</p> <p>Background</p> <p>Little information is available on the effect of allergen-specific immunotherapy on airway responsiveness and markers in exhaled air. The aims of this study were to assess the safety of immunotherapy with purified natural Alt a1 and its effect on airway responsiveness to direct and indirect bronchoconstrictor agents and markers in exhaled air.</p> <p>Methods</p> <p>This was a randomized double-blind trial. Subjects with allergic rhinitis with or without mild/moderate asthma sensitized to <it>A alternata </it>and who also had a positive skin prick test to Alt a1 were randomized to treatment with placebo (n = 18) or purified natural Alt a1 (n = 22) subcutaneously for 12 months. Bronchial responsiveness to adenosine 5'-monophosphate (AMP) and methacholine, exhaled nitric oxide (ENO), exhaled breath condensate (EBC) pH, and serum Alt a1-specific IgG₄antibodies were measured at baseline and after 6 and 12 months of treatment. Local and systemic adverse events were also registered.</p> <p>Results</p> <p>The mean (95% CI) allergen-specific IgG₄value for the active treatment group increased from 0.07 μg/mL (0.03-0.11) at baseline to 1.21 μg/mL (0.69-1.73, P < 0.001) at 6 months and to 1.62 μg/mL (1.02-2.22, P < 0.001) at 12 months of treatment. In the placebo group, IgG₄value increased nonsignificantly from 0.09 μg/mL (0.06-0.12) at baseline to 0.13 μg/mL (0.07-0.18) at 6 months and to 0.11 μg/mL (0.07-0.15) at 12 months of treatment. Changes in the active treatment group were significantly higher than in the placebo group both at 6 months (P < 0.001) and at 12 months of treatment (P < 0.0001). However, changes in AMP and methacholine responsiveness, ENO and EBC pH levels were not significantly different between treatment groups. The overall incidence of adverse events was comparable between the treatment groups.</p> <p>Conclusion</p> <p>Although allergen-specific immunotherapy with purified natural Alt a1 is well tolerated and induces an allergen-specific IgG₄response, treatment is not associated with changes in AMP or methacholine responsiveness or with significant improvements in markers of inflammation in exhaled air. These findings suggest dissociation between the immunotherapy-induced increase in IgG₄levels and its effect on airway responsiveness and inflammation.</p