2,747 research outputs found
Symmetries and Triplet Dispersion in a Modified Shastry-Sutherland Model for SrCu_2(BO_3)_2
We investigate the one-triplet dispersion in a modified Shastry-Sutherland
Model for SrCu_2(BO_3)_2 by means of a series expansion about the limit of
strong dimerization. Our perturbative method is based on a continuous unitary
transformation that maps the original Hamiltonian to an effective, energy
quanta conserving block diagonal Hamiltonian H_{eff}. The dispersion splits
into two branches which are nearly degenerated. We analyse the symmetries of
the model and show that space group operations are necessary to explain the
degeneracy of the dispersion at k=0 and at the border of the magnetic Brillouin
zone. Moreover, we investigate the behaviour of the dispersion for small |k|
and compare our results to INS data.Comment: 9 pages, 8 figures accepted by J. Phys.: Condens. Matte
SrCu_2(BO_3)_2 - a Two Dimensional Spin Liquid
We study an extended Shastry-Sutherland model for SrCu_2(BO_3)_2 and analyze
the low lying parts of the energy spectrum by means of a perturbative unitary
transformation based on flow equations. The derivation of the 1-magnon
dispersion (elementary triplets) is discussed. Additionally, we give a
quantitative description (symmetries and energies) of bound states made from
two elementary triplets. Our high order results allow to fix the model
parameters for SrCu_2(BO_3)_2 precisely: J_1=6.16(10)meV, x:=J_2/J_1=0.603(3),
J_\perp=1.3(2)meV. To our knowledge this is the first quantitative treatment of
bound states in a true 2d model.Comment: 4 pages, 3 figures, Proceeding paper of the HFM2000 conference in
Waterloo, Canada, Jun 200
The Signal Sequence Receptor Has a Second Subunit and IsPart of a Translocation Complex in the Endoplasmic Reticulum as Probed by Bifunctional Reagents
Bifunctional cross-linking reagents were used to probe the protein environment in the ER membrane of the signal sequence receptor (SSR), a 34-kD integral membrane glycoprotein (Wiedmann, M., T. V. Kurzchalia, E. Hartmarm, and T. A. Rapoport. 1987. Nature [Lond.]. 328:830-833). The proximity of several polypeptides was demonstrated. A 22-kD glycoprotein was identified tightly bound to the 34-kD SSR even after membrane solubilization. The 34-kD polypeptide, now termed otSSR, and the 22-kD polypeptide, the #SSR, represent a heterodimer. We report on the sequence of the/3SSR, its membrane topology, and on the mechanism of its integration into the membrane. Cross-linking also produced dimers of the a-subunit of the SSR indicating that oligomers of the SSR exist in the ER membrane. Various bifunctional cross-linking reagents were used to study the relation to ER membrane proteins of nascent chains of preprolactin and/3-1actamase at different stages of their translocation through the membrane. The predominant cross-linked products obtained in high yields contained the aSSR, indicating in conjunction with previous results that it is a major membrane protein in the neighborhood of translocating nascent chains of secretory proteins. The results support the existence of a translocon, a translocation complex involving the SSR, which constitutes the specific site of protein translocation across the ER membrane
Dispersion and Symmetry of Bound States in the Shastry-Sutherland Model
Bound states made from two triplet excitations on the Shastry-Sutherland
(ShaSu) lattice are investigated. Based on the perturbative unitary
transformation by flow equations quantitative properties like dispersions and
qualitative properties like symmetries are determined. The high order results
(up to (J_2/J_1)^{14}) permit to fix the parameters of SrCu_2(BO_3)_2
precisely: J_1=6.16(10)meV, x:=J_2/J_1=0.603(3), J_\perp=1.3(2)meV. At the
border of the magnetic Brillouin zone (MBZ) a general double degeneracy is
derived. An unexpected instability in the triplet channel at x=0.63 indicates a
first order transition towards a triplet condensate, related to classical
helical order.Comment: 4 pages, submitted to Phys. Rev. Let
Generalised Shastry-Sutherland Models in three and higher dimensions
We construct Heisenberg anti-ferromagnetic models in arbitrary dimensions
that have isotropic valence bond crystals (VBC) as their exact ground states.
The d=2 model is the Shastry-Sutherland model. In the 3-d case we show that it
is possible to have a lattice structure, analogous to that of SrCu_2(BO_3)_2,
where the stronger bonds are associated with shorter bond lengths. A dimer mean
field theory becomes exact at d -> infinity and a systematic 1/d expansion can
be developed about it. We study the Neel-VBC transition at large d and find
that the transition is first order in even but second order in odd dimensions.Comment: Published version; slightly expande
Hole dynamics and photoemission in a t-J model for SrCu_2(BO_3)_2
The motion of a single hole in a t-J model for the two-dimensional spin-gap
compound SrCu_2(BO_3)_2 is investigated. The undoped Heisenberg model for this
system has an exact dimer eigenstate and shows a phase transition between a
dimerized and a Neel phase at a certain ratio of the magnetic couplings. We
calculate the photoemission spectrum in the disordered phase using a
generalized spin-polaron picture. By varying the inter-dimer hopping parameters
we find a cross-over between a narrow quasiparticle band regime known from
other strongly correlated systems and free-fermion behavior. The hole motion in
the Neel-ordered phase is also briefly considered.Comment: 4 pages, 3 fig
Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus
Structural analysis of the inhibitor Telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A shows that mutations at V36 and/or T54 result in impaired interaction with VX-950, explaining the development of viral breakthrough variants
Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma
Using tissue microarrays (TMAs) we studied COX2/PPARG immunoreactivity in a broad spectrum of tumors focussing on clinicopathological correlations and the outcome of patients with malignant melanoma (MM).
TMA-1 contained normal and tumor tissues (n = 3448) from 47 organs including skin neoplasms (n = 323); TMA-2 88 primary MM, 101 metastases, and 161 benign nevi. Based on a biomodulatory approach combining COX/PPAR-targeting with metronomic low-dose chemotherapy metastases of 36 patients participating in a randomized trial with metastatic (stage IV) melanoma were investigated using TMA-3. COX2/PPARG immunoreactivity significantly increased from nevi to primary MM and metastases; COX2 positivity was associated with advanced Clark levels and shorter recurrence-free survival. Patients with PPARG-positive metastases and biomodulatory metronomic chemotherapy alone or combined with COX2/PPARG-targeting showed a significantly prolonged progression-free survival. Regarding primary MM, COX2 expression indicates an increased risk of tumor recurrence. In metastatic MM, PPARG expression may be a predicitive marker for response to biomodulatory stroma-targeted therapy
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