80 research outputs found
Presence of Parabens and Bisphenols in Food Commonly Consumed in Spain
Given the widespread use of bisphenols and parabens in consumer products, the assessment of their intake is crucial and represents the first step towards the assessment of the potential risks that these compounds may pose to human health. In the present study, a total of 98 samples of food items commonly consumed by the Spanish population were collected from different national supermarkets and grocery stores for the determination of parabens and bisphenols. Our analysis demonstrated that 56 of the 98 food samples contained detectable levels of parabens with limits of quantification (LOQ) between 0.4 and 0.9 ng g-1. The total concentration of parabens (sum of four parabens: åparabens) ranged from below the LOQ to 281.7 ng g-1, with a mean value of 73.86 ng g-1. A total of 52% of the samples showed detectable concentrations of bisphenols. Bisphenol A (BPA) was the most frequently detected bisphenol in the food samples analysed, followed by bisphenol S (BPS) and bisphenol E (BPE). Bisphenol AF (BPAF), bisphenol B (BPB) and bisphenol P (BPP) were not found in any of the analysed samples. LOQ for these bisphenols were between 0.4 and 4.0 ng g-1
Scutoids are a geometrical solution to three-dimensional packing of epithelia
As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term “scutoid”. The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.España Ministerio de Ciencia y Tecnología BFU2013-48988-C2-1-P and BFU2016-8079
Planeamiento estratégico para la región Piura
El presente Plan Estratégico de la Región Piura se elaboró siguiendo el modelo
secuencial del proceso estratégico de D’Alessio. Se identificaron como ejes de crecimiento
hacia el 2028 la agroindustria de exportación, focalizada en productos no tradicionales y
orgánicos; así como en el sector del turismo de playa de hoteles de lujo. La Región Piura es
una región privilegiada en recursos naturales, situada en una zona estratégica para el
comercio y con un nivel de crecimiento poblacional que brinda una gran esperanza de
desarrollo a futuro y una ventaja competitiva a explotar.
El Gobierno Regional de Piura, dirigido por el Presidente Regional, será el
responsable de dirigir la ejecución de los planes y programas del Gobierno Regional, por lo
tanto, la formulación de este plan estratégico se centra en acciones y estrategias a ser
implementadas por dicha administración. Con ello, se busca incrementar el empleo e
impulsar el crecimiento sostenido en la región, logrando un mayor beneficio económico y
social de su población.The present Strategic Plan of the Piura Region was elaborated following the
sequential model of D'Alessio's strategic process. The agro-industry for export, focused on
non-traditional and organic products, was identified as growth axes by 2028; as well as in the
beach tourism sector of luxury hotels. The Piura Region is a region privileged in natural
resources, located in a strategic area for trade and with a level of population growth that
provides great hope for future development and a competitive advantage to exploit.
The Regional Government of Piura, headed by the Regional President, will be
responsible for directing the execution of the plans and programs of the Regional
Government, therefore, the formulation of this strategic plan focuses on actions and strategies
to be implemented by said administration. With this, it seeks to increase employment and
boost sustained growth in the region, achieving greater economic and social benefits for its
population.Tesi
Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study
Introduction: A growing number of studies link the increase in overweight/
obesity worldwide to exposure to certain environmental chemical pollutants that
display obesogenic activity (obesogens). Since exposure to obesogens during
the first stages of life has been shown to have a more intense and pronounced
effect at lower doses, it is imperative to study their possible effects in childhood.
The objective here was to study the association of Bisphenol A (BPA) and 11 BPA
analogs in children, using three biological matrices (nails, saliva and urine), and
overweight and obesity (n = 160).
Methods: In this case–control study, 59 overweight/obese children and 101
controls were included. The measuring of Bisphenols in the matrices was carried
out by ultra-high performance liquid chromatography coupled with triple
quadrupole tandem mass spectrometry (UHPLC-MS/MS). Logistic regression
was used to study the association between overweight/obesity and Bisphenol
exposure.
Results: The results suggested that BPF in nails is associated with overweight/
obesity in children (OR:4.87; p = 0.020). In saliva, however, the highest detected
concentrations of BPAF presented an inverse association (OR: 0.06; p = 0.010)
with overweight/obesity. No associations of statistical significance were detected
between exposure to BPA or its other analogs and overweight/obesity in any of
the biological matrices.FEDER-Consejería de Salud y Familias’ of the Junta de Andalucía PE-0250-201
Tigecycline reduces tumorigenesis in colorectal cancer via inhibition of cell proliferation and modulation of immune response
Junta de Andalucía (CTS 164)Instituto de Salud Carlos III (Spain)Fondo Europeo de Desarrollo
Regional (FEDER)European Union, through the research
grants PI18/00826, P18-RT-4930, PI0206–2016, PIE16/00045 and
PI19/01058Spanish Ministry of Science and Innovation (MCIN/AEI/
10.13039/501100011033/FEDER)RTI2018–101309-BC22Chair “Doctors Galera-Requena in cancer stem cell
research” (CMC-CTS963Spanish Ministry of Science and Innovation (“Programa de
Doctorado: Medicina Clínica y Salud Pública” B12.56.1).Instituto de Salud Carlos III
(FI17/00176)Junta de Andalucía
(P18-RT-4930)University
of GranadaCIBER-EHD is funded by the Instituto de Salud Carlos
II
The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice
Nowadays, there is an increasing interest in alternative therapies in the treatment of
metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate
the effect of an extract of Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-
induced obesity mice, highlighting the impact of its antioxidant activity on the inflammatory status
and gut dysbiosis. The extract was administered daily (50, 100 and 150 mg/kg) in HFD-fed mice.
The treatment reduced body weight gain, glucose and lipid metabolic profiles. Moreover, the extract
ameliorated the inflammatory status, with the c-Jun N-terminal kinases (JUNK) pathway being
involved, and showed a significant antioxidant effect by the reduction of radical scavenging activity
and the mitigation of lipid peroxidation. Moreover, the extract was able to modulate the altered gut
microbiota, restoring microbial richness and diversity, and augmenting the counts of short-chain fatty
acid producing bacteria, which have been associated with the maintenance of gut permeability and
weight regulation. In conclusion, the antioxidant activity of Thymus serpyllum extract displayed a
positive impact on obesity and its metabolic alterations, also reducing systemic inflammation. These
effects may be mediated by modulation of the gut microbiota.Junta de Andalucia CTS 164Instituto de Salud Carlos III
European Commission PI19.01058Spanish Government AGL201567995-C3-3-REuropean CommissionInstituto de Salud Carlos II
Comparative Study of the Antioxidant and Anti-Inflammatory E ects of Leaf Extracts from Four Di erent Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice
The authors declare no conflict of interest. The funders had no role in the design of the study;
in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish
the results.Increased levels of reactive oxygen species (ROS) and a low-grade chronic inflammation in
multiple organs have been demonstrated in obesity. Morus alba leaves extracts (MAEs) have been used
in traditional medicine as anti-inflammatory agents. In this work, the bioactive compounds of di erent
genotypes of M. alba L. (Filipina, Valenciana Temprana, Kokuso, and Italia) were analyzed not only by
reverse phase high performance liquid chromatography–electrospray ionization-time of flight-mass
spectrometry (RP-HPLC-ESI-TOF-MS) and hydrophilic interaction chromatography–electrospray
ionization-time of flight-mass spectrometry (HILIC-ESI-TOF-MS), but also screened for in vitro and
in vivo antioxidant activity by means of DPPH radical scavenging assay and Caenorhabditis elegans
model. These MAEs were administered daily in a model of diet-induced obesity in mice. Filipina
and Italia genotypes significantly reduced weight gain, the glycemic levels in high fat diet, as well
as, levels of LDL-cholesterol and triglycerides. Filipina and Italia MAEs also reduced the expression
of proinflammatory mediators such as Tnf- , Il-1 , Il-6 and increased the levels of adiponectin and
AMPK, which exert anti-inflammatory e ects. Moreover, Italia genotype ameliorated the intestinal
barrier function. In conclusion, Filipina and Italia methanolic extracts show the highest antioxidant
and anti-inflammatory e ect, due to the presence of compounds such as protocatechuic acid or
quercetin-3-glucoside, and they could be developed as a complementary treatment for obesity and
metabolic disorders.Junta de Andalucia
CTS 164Spanish Ministry of Economy and Competitiveness
AGL2015-67995-C3-3-REuropean Commission (FEDER/ERDF)ERDF/FEDER Operational Programme of the Region of Murcia
2007ES161PO001
14-20/20Instituto de Salud Carlos II
Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis
This work has been supported from the European Commission ERDF/FEDER Operational Programme `Murcia' CCI N. 2007ES161PO001 (Project No. 14-20/20), the Junta de Andalucia (CTS164), Instituto de Salud Carlos III (PI19/01058) and the Spanish MINECO (Ref. CTQ201787708-R). P.D.-E. is a postdoctoral from Junta de Andalucia (European Commission FEDER); A.J.R.-M and L.H.-G. are predoctoral fellows from University of Granada ("Programa de Doctorado: Medicina Clinica y Salud Publica"); A.A.L.-P's research contract was supported by the ERDF/FEDER Operational Programme `Murcia' CCI N 2007ES161PO001 (Project No. 14-20/20); A.R.-N. is a postdoctoral fellow of Instituto de Salud Carlos III (Miguel Servet Program); T.V. is a postdoctoral fellow from Instituto de Investigación Biosanitaria de Granada.Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder affecting the gastrointes-tinal tract. The pharmacological treatments used currently for its treatment lack efficacy, so new therapeutic strategies should be developed. In this context, flavonoids loaded in biopolymeric nanoparticles can be considered as novel promising candidates. The aim of the present study was to evaluate the intestinal anti-inflammatory effects of quercetin when is administered loaded in silk fibroin nanoparticles (QSFN) in the dextran sulphate sodium experimental model of mouse colitis, which displays some similarities to human IBD. Previously characterized quercetin-loaded silk fibroin nanoparticles (QSFN). QSFN showed a reversible aggre-gation profile induced by the acidification of the solution but did not affect the loaded quercetin. Daily administration of QSFN significantly reduced disease activity index values compared to the control colitic group. This beneficial effect was not only corroborated by the histological examination of the colonic specimens but also the improvement of the colonic expression of the different proinflammatory cytokines (Tnf-alpha, Il-1 beta, Il-6, Mcp-1, Icam-1, Nlrp3 and iNOS). Therefore, these data suggest that QSFN could be a promising alternative to current treatments as a drug delivery system for IBD treatment.European Commission ERDF/FEDER Operational Programme `Murcia' CCI 2007ES161PO001- 14-20/20Junta de Andalucia CTS164Instituto de Salud Carlos III
European Commission PI19/01058Spanish MINECO CTQ201787708-RERDF/FEDER Operational Programme 'Murcia' CCI 2007ES161PO001- 14-20/2
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