EGF induces dimerization of modified EGF receptors.

<p>SDS-PAGE analysis of EGFR dimerization. EGFR+EGF Lane, unmodified EGF receptors with EGF present. EGFR Lane, unmodified EGF receptors without EGF present. mod. EGFR + EGF Lane, modified EGF receptors with EGF present. mod. EGFR Lane, modified EGF receptors without EGF present. EGF Lane, only EGF present (no EGF receptors present).</p

Encapsulated drug leakage from a MLV (schematic).

<p>A homogeneous, spherically symmetric, drug-encapsulating MLV.</p

MRBL-borne modified EGF receptors show binding specificity for EGF.

<p>Binding of [¹²⁵I]EGF to MRBLs as assessed by liquid scintillation counting. Ctrl, MRBLs pre-incubated with an excess of unlabeled EGF before incubation with [¹²⁵I]EGF. Expt, MRBLs not pre-incubated with an excess of unlabeled EGF before incubation with [¹²⁵I]EGF.</p

Production of liposomes in a CTR.

<p>Predicted concentrations of reagents and drug-encapsulating liposomes as a function of reactor position. Initial conditions used: [TR] = 500 arbitrary units (a.u.); [DRG] = 50000 a.u.; [DEL] = 0 a.u.</p

MRBL-borne modified EGF receptor dimers interact with the MRBL lipid bilayer to increase MRBL permeability (schematic).

<p>Dimerization of MRBL-borne modified EGF receptors. ext. sol'n, exterior solution. EGFR, modified EGF receptors. int., interior of unilamellar MRBL. X-----, crosslinked p-toluic acid or methyl-PEO₄-NHS ester.</p

Vascular mass transfer of liposomes (schematic).

<p>Migration of liposomes in a blood vessel. Applicable mass transfer coefficients are shown.</p

EGF in solution increases rate of encapsulated actinomycin D release.

<p>Percentage (expressed as fraction released) of encapsulated actinomycin D released as assessed by ¹H NMR spectroscopy. Baseline Ctrl, actinomycin D-encapsulating MRBLs without growth factor added to solution. Grth Fctr Ctrl, actinomycin D-encapsulating MRBLs with VEGF added to solution. Expt, actinomycin D-encapsulating MRBLs with EGF added to solution.</p

Additional file 2: of Determinants of first-time utilization of long-term care services in the Netherlands: an observational record linkage study

Model selection. Statistical information and description of the model selection process. (XLSX 20 kb

Additional file 2: of Comparing the effect of a leaflet and a movie in preventing tick bites and Lyme disease in The Netherlands

Additional figures not significant results. (DOCX 133 kb

MOESM3 of Estimation of acute and chronic Q fever incidence in children during a three-year outbreak in the Netherlands and a comparison with international literature

Additional file 3: Figure S3. Seroprevalence in symptomatic patient groups