134 research outputs found
Targeted Imaging Offers Advantages Over Physiological Imaging for Evaluation of Angiogenic Therapy⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Myocardial perfusion imaging with a novel selective A2a adenosine receptor agonist (CVT-3146): Important differences in radiotracer behavior
Dense nonrigid motion tracking from a sequence of velocity fields
We have addressed the problem of tracking the non-rigid motion of the heart using a sequence of velocity fields and a sequence of contours. The information from both the contours and the dense velocity fields is integrated into a deforming mesh that is placed over the myocardium at one time frame and then tracked over the entire cardiac cycle. The deformation is guided by a smoothing filter that provides a compro-mise between (i) believing the dense field velocity and the contour data when it is crisp and coherent in a local spatial and temporal sense and (ii) employing a temporally smooth cyclic model of cardiac motion when contour and velocity data are not trustworthy. The method has been carefully evaluated with simu-lated data and phantom data. Experiments with in vivo data have also been conducted.
The impact of system matrix dimension on small FOV SPECT reconstruction with truncated projections
Purpose: A dedicated cardiac hybrid single photon emission computed tomography (SPECT)/CT scanner that uses cadmium zinc telluride detectors and multiple pinhole collimators for stationary acquisition offers many advantages. However, the impact of the reconstruction system matrix (SM) dimension on the reconstructed image quality from truncated projections and 19 angular samples acquired on this scanner has not been extensively investigated. In this study, the authors aimed to investigate the impact of the dimensions of SM and the use of body contour derived from adjunctive CT imaging as an object support in reconstruction on this scanner, in relation to background extracardiac activity. Methods: The authors first simulated a generic SPECT/CT system to image four NCAT phantoms with various levels of extracardiac activity and compared the reconstructions using SM in different dimensions and with/without body contour as a support for quantitative evaluations. The authors then compared the reconstructions of 18 patient studies, which were acquired on a GE Discovery NM570c scanner following injection of different radiotracers, including 99mTc-Tetrofosmin and 123I-mIBG, comparing the scanner\u27s default SM that incompletely covers the body with a large SM that incorporates a patient specific full body contour. Results: The simulation studies showed that the reconstructions using a SM that only partially covers the body yielded artifacts on the edge of the field of view (FOV), overestimation of activity and increased nonuniformity in the blood pool for the phantoms with higher relative levels of extracardiac activity. However, the impact on the quantitative accuracy in the high activity region such as the myocardium, was subtle. On the other hand, an excessively large SM that enclosed the entire body alleviated the artifacts and reduced overestimation in the blood pool, but yielded slight underestimation in myocardium and defect regions. The reconstruction using the larger SM with body contour yielded the most quantitatively accurate results in all the regions of interest for a range of uptake levels in the extracardiac regions. In patient studies, the SM incorporating patient specific body contour minimized extracardiac artifacts, yielded similar myocardial activity, lower blood pool activity, and subsequently improved myocardium-to-blood pool contrast (p\u3c0.0001) by an average of 7% (range 0%-18%) across all the patients, compared to the reconstructions using the scanner\u27s default SM. Conclusions: Their results demonstrate that using a large SM that incorporates a CT derived body contour in the reconstruction could improve quantitative accuracy within the FOV for clinical studies with high extracardiac activity
Characterization of myocardial remodeling with diffusion tensor magnetic resonance imaging in chronic porcine model using the toroid-based representation
Towards high-resolution fat-suppressed T1-mapping of atrial fibrosis in the left atrium: a fit-free three-point method
- …