5,275 research outputs found
Dipole Oscillations of a Bose-Einstein Condensate in Presence of Defects and Disorder
We consider dipole oscillations of a trapped dilute Bose-Einstein condensate
in the presence of a scattering potential consisting either in a localized
defect or in an extended disordered potential. In both cases the breaking of
superfluidity and the damping of the oscillations are shown to be related to
the appearance of a nonlinear dissipative flow. At supersonic velocities the
flow becomes asymptotically dissipationless.Comment: 4 pages, 4 figure
Solomon Islands: Western Province situation analysis
Aquatic agricultural systems (AAS) are places where farming and fishing in freshwater and/orscoastal ecosystems contribute significantly to household income and food security. Globally, theslivelihoods of many poor and vulnerable people are dependent on these systems. In recognitionsof the importance of AAS, the CGIAR Research Program (CRP) is undertaking a new generationsof global agricultural research programs on key issues affecting global food security and ruralsdevelopment. The overall goal of the research program is to improve the well-being of peoplesdependent on these systems. Solomon Islands is one of five priority countries in the AAS program,sled by WorldFish. In Solomon Islands, the AAS program operates in the Malaita Hub (MalaitasProvince) and the Western Hub (Western Province). This program and its scoping activities aressummarized in this report
Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2)
Previous studies in yeast and mammalian cells showed a functional
interaction between the amino-terminal domain and the carboxy-terminal,
ligand-binding domain (LBD) of the human androgen receptor (AR). In the
present study, the AR subdomains involved in this in vivo interaction were
determined in more detail. Cotransfection experiments in Chinese hamster
ovary (CHO) cells and two-hybrid experiments in yeast revealed that two
regions in the NH2-terminal domain are involved in the functional
interaction with the LBD: an interacting domain at the very NH2 terminus,
located between amino acid residues 3 and 36, and a second domain,
essential for transactivation, located between residues 370 and 494.
Substitution of glutamic acid by glutamine at position 888 (E888Q) in the
AF-2 activation domain (AD) core region in the LBD, markedly decreased the
interaction with the NH2-terminal domain. This mutation neither influenced
hormone binding nor LBD homodimerization, suggesting a role of the AF-2 AD
core region in the functional interaction between the NH2-terminal domain
and the LBD. The AF-2 AD core region was also involved in the interaction
with the coactivator TIF2 (transcriptional intermediary factor 2), as the
E888Q mutation decreased the stimulatory effect of TIF2 on AR AF-2
activity. Cotransfection of TIF2 and the AR NH2-terminal domain expression
vectors did not result in synergy between both factors in the induction of
AR AF-2 activity. TIF2 highly induced AR AF-2 activity on a complex
promoter [mouse mammary tumor virus (MMTV)], but it was hardly active on a
minimal promoter (GRE-TATA). In contrast, the AR NH2-terminal domain
induced AR AF-2 activity on both promoter constructs. These data indicate
that both the AR NH2-terminal domain and the coactivator TIF2 functionally
interact, either directly or indirectly, with the AF-2 AD core region in
the AR-LBD, but the level of transcriptional response induced by TIF2
depends on the promoter context
A 140 GHz pulsed EPR/212 MHz NMR spectrometer for DNP studies
We described a versatile spectrometer designed for the study of dynamic nuclear polarization (DNP) at low temperatures and high fields. The instrument functions both as an NMR spectrometer operating at 212 MHz ([superscript 1]H frequency) with DNP capabilities, and as a pulsed-EPR operating at 140 GHz. A coiled TE[subscript 011] resonator acts as both an NMR coil and microwave resonator, and a double balanced ([superscript 1]H, [superscript 13]C) radio frequency circuit greatly stabilizes the NMR performance. A new 140 GHz microwave bridge has also been developed, which utilizes a four-phase network and ELDOR channel at 8.75 GHz, that is then multiplied and mixed to obtain 140 GHz microwave pulses with an output power of 120 mW. Nutation frequencies obtained are as follows: 6 MHz on S = 1/2 electron spins, 100 kHz on [superscript 1]H, and 50 kHz on [superscript 13]C. We demonstrate basic EPR, ELDOR, ENDOR, and DNP experiments here. Our solid effect DNP results demonstrate an enhancement of 144 and sensitivity gain of 310 using OX063 trityl at 80 K and an enhancement of 157 and maximum sensitivity gain of 234 using Gd-DOTA at 20 K, which is significantly better performance than previously reported at high fields (⩾3 T).National Institutes of Health (U.S.) (EB002804)National Institutes of Health (U.S.) (EB002026)National Institutes of Health (U.S.) (EB001965)National Institutes of Health (U.S.) (EB004866)Deutsche Forschungsgemeinschaft (Postdoctoral Fellowship
Соматоформная вегетативная дисфункция у лиц молодого возраста в свете современньїх представлений об этиопатогенезе, диагностике и методах восстановительного лечения
Guiding the self-assembly of materials by controlling the shape of the individual particle constituents is a powerful approach to material design. We show that colloidal silica superballs crystallize into canted phases in the presence of depletants. Some of these phases are consistent with the so-called "Λ1" lattice that was recently predicted as the densest packing of superdisks. As the size of the depletant is reduced, however, we observe a transition to a square phase. The differences in these entropically stabilized phases result from an interplay between the size of the depletants and the fine structure of the superball shape. We find qualitative agreement of our experimental results both with a phase diagram computed on the basis of the volume accessible to the depletants and with simulations. By using a mixture of depletants, one of which is thermosensitive, we induce solid-to-solid phase transitions between square and canted structures. The use of depletant size to leverage fine features of the shape of particles in driving their self-assembly demonstrates a general and powerful mechanism for engineering novel materials
The Northwest Tropical Atlantic Station (NTAS) : NTAS-4 mooring turnaround cruise report
The Northwest Tropical Atlantic Station (NTAS) was established to address the need for accurate air-sea flux estimates and upper
ocean measurements in a region with strong sea surface temperature anomalies and the likelihood of significant local air–sea
interaction on interannual to decadal timescales. The approach is to maintain a surface mooring outfitted for meteorological and
oceanographic measurements at a site near 15°N, 51°W by successive mooring turnarounds. These observations will be used to
investigate air–sea interaction processes related to climate variability.
Deployment of the first (NTAS-1), second (NTAS-2) and third (NTAS-3) moorings were documented in previous reports
(Plueddemann et al., 2001; 2002; 2003). This report documents recovery of the NTAS-3 mooring and deployment of the NTAS-4
mooring at the same site. Both moorings used 3-meter discus buoys as the surface element. These buoys were outfitted with two
Air–Sea Interaction Meteorology (ASIMET) systems. Each system measures, records, and transmits via Argos satellite the surface
meteorological variables necessary to compute air–sea fluxes of heat, moisture and momentum. The upper 150 m of the mooring line
were outfitted with oceanographic sensors for the measurement of temperature and velocity.
The mooring turnaround was done on the NOAA ship Ronald H. Brown, Cruise RB-04-01, by the Upper Ocean Processes Group of
the Woods Hole Oceanographic Institution. The cruise took place between 12 and 25 February 2004. The NTAS-3 buoy was found
adrift and recovered on 19 February at 14°53.7’N, 51°22.8’W. Deployment of the NTAS-4 mooring was on 21 February at
approximately 14°44.4’N, 50°56.0’W in 5038 m of water. A 30-hour intercomparison period followed, after which dragging
operations to recover the lower portion of the NTAS-3 mooring commenced. This report describes these operations, as well as other
work done on the cruise and some of the pre-cruise buoy preparations.Funding was provided by the National Oceanic and Atmospheric Administration
under Grant No. NA17RJ1223 and the Cooperative Institute for Climate and Ocean Research (CICOR)
Cascading Dynamics in Modular Networks
In this paper we study a simple cascading process in a structured
heterogeneous population, namely, a network composed of two loosely coupled
communities. We demonstrate that under certain conditions the cascading
dynamics in such a network has a two--tiered structure that characterizes
activity spreading at different rates in the communities. We study the dynamics
of the model using both simulations and an analytical approach based on
annealed approximation, and obtain good agreement between the two. Our results
suggest that network modularity might have implications in various
applications, such as epidemiology and viral marketing.Comment: 5 pages, 4 figure
Quantum Robots and Environments
Quantum robots and their interactions with environments of quantum systems
are described and their study justified. A quantum robot is a mobile quantum
system that includes a quantum computer and needed ancillary systems on board.
Quantum robots carry out tasks whose goals include specified changes in the
state of the environment or carrying out measurements on the environment. Each
task is a sequence of alternating computation and action phases. Computation
phase activities include determination of the action to be carried out in the
next phase and possible recording of information on neighborhood environmental
system states. Action phase activities include motion of the quantum robot and
changes of neighborhood environment system states. Models of quantum robots and
their interactions with environments are described using discrete space and
time. To each task is associated a unitary step operator T that gives the
single time step dynamics. T = T_{a}+T_{c} is a sum of action phase and
computation phase step operators. Conditions that T_{a} and T_{c} should
satisfy are given along with a description of the evolution as a sum over paths
of completed phase input and output states. A simple example of a task carrying
out a measurement on a very simple environment is analyzed. A decision tree for
the task is presented and discussed in terms of sums over phase paths. One sees
that no definite times or durations are associated with the phase steps in the
tree and that the tree describes the successive phase steps in each path in the
sum.Comment: 30 Latex pages, 3 Postscript figures, Minor mathematical corrections,
accepted for publication, Phys Rev
Amino acids 3-13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor
The N-terminal domain (NTD) and the ligand-binding domain (LBD) of the
androgen receptor (AR) exhibit a ligand-dependent interaction (N/C
interaction). Amino acids 3-36 in the NTD (AR3-36) play a dominant role in
this interaction. Previously, it has been shown that a PhixxPhiPhi motif
in AR3-36, 23FxxLF27, is essential for LBD interaction. We demonstrate in
the current study that AR3-36 can be subdivided into two functionally
distinct fragments: AR3-13 and AR16-36. AR3-13 does not directly interact
with the AR LBD, but rather contributes to the transactivation function of
the AR.NTD-AR.LBD complex. AR16-36, encompassing the 23FxxLF27 motif, is
predicted to fold into a long amphipathic alpha-helix. A second
PhixxPhiPhi candidate protein interaction motif within the helical
structure, 30VREVI34, shows no affinity to the LBD. Within AR16-36, amino
acid residues in and flanking the 23FxxLF27 motif are demonstrated to
modulate N/C interaction. Substitution of Q24 and N25 by alanine residues
enhances N/C interaction. Substitution of amino acids flanking the
23FxxLF27 motif by alanines are inhibitory to LBD interaction
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