5 research outputs found
Estudio de soluciones para la reparación del punto crítico nº19 del tramo Otanche-Pauna de la carretera troncal de Boyacá (Colombia)
[ES] Se realizará el estudio geológico-geotécnico y de estabilidad de los taludes del punto crítico nº19 del tramo Otanche-Pauna de la carretera troncal de Boyacá (Colombia) del PK 33+900 a PK 34+090 que se pretende ampliar para la mejora de la seguridad vial de la zona, para ello a partir de datos geomecánicos de campo se realizará un análisis de la situación a través de los procedimientos vistos en las asignaturas del grado.
Asimismo, se realizará un estudio geológico y un estudio de soluciones contemplando diferentes alternativas en lo que a la estabilidad de los taludes se refiere, escogiendo finalmente la más adecuada.
Para finalizar, se describirá la solución adoptada y se realizará una valoración económica junto a un plan de trabajos para poder ejecutarla.Alba Quesada, S. (2020). Estudio de soluciones para la reparación del punto crítico nº19 del tramo Otanche-Pauna de la carretera troncal de Boyacá (Colombia). http://hdl.handle.net/10251/150391TFG
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysisResearch in context
Summary: Background: Pseudomonas aeruginosa healthcare-associated infections are one of the top antimicrobial resistance threats world-wide. In order to analyze the current trends, we performed a Spanish nation-wide high-resolution analysis of the susceptibility profiles, the genomic epidemiology and the resistome of P. aeruginosa over a five-year time lapse. Methods: A total of 3.180 nonduplicated P. aeruginosa clinical isolates from two Spanish nation-wide surveys performed in October 2017 and 2022 were analyzed. MICs of 13 antipseudomonals were determined by ISO-EUCAST. Multidrug resistance (MDR)/extensively drug resistance (XDR)/difficult to treat resistance (DTR)/pandrug resistance (PDR) profiles were defined following established criteria. All XDR/DTR isolates were subjected to whole genome sequencing (WGS). Findings: A decrease in resistance to all tested antibiotics, including older and newer antimicrobials, was observed in 2022 vs 2017. Likewise, a major reduction of XDR (15.2% vs 5.9%) and DTR (4.2 vs 2.1%) profiles was evidenced, and even more patent among ICU isolates [XDR (26.0% vs 6.0%) and DTR (8.9% vs 2.6%)] (p < 0.001). The prevalence of Extended-spectrum β-lactamase/carbapenemase production was slightly lower in 2022 (2.1%. vs 3.1%, p = 0.064). However, there was a significant increase in the proportion of carbapenemase production among carbapenem-resistant strains (29.4% vs 18.1%, p = 0.0246). While ST175 was still the most frequent clone among XDR, a slight reduction in its prevalence was noted (35.9% vs 45.5%, p = 0.106) as opposed to ST235 which increased significantly (24.3% vs 12.3%, p = 0.0062). Interpretation: While the generalized decrease in P. aeruginosa resistance, linked to a major reduction in the prevalence of XDR strains, is encouraging, the negative counterpart is the increase in the proportion of XDR strains producing carbapenemases, associated to the significant advance of the concerning world-wide disseminated hypervirulent high-risk clone ST235. Continued high-resolution surveillance, integrating phenotypic and genomic data, is necessary for understanding resistance trends and analyzing the impact of national plans on antimicrobial resistance. Funding: MSD and the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea—NextGenerationEU
Geodivulgar: Geología y Sociedad
Depto. de Geodinámica, Estratigrafía y PaleontologíaDepto. de Química InorgánicaDepto. de Didáctica de las Ciencias Experimentales , Sociales y MatemáticasFac. de Ciencias GeológicasFac. de Ciencias QuímicasFac. de EducaciónFALSEsubmitte
Geodivulgar: Geología y Sociedad
Memoria final del Proyecto Innova Docencia 2023-23 nº 58. GEODIVULGAR: Geología y SociedadUCMDepto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasFALSEsubmitte