2 research outputs found
Additional file 2: Figure S1. of Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats
Real time RTâÂÂPCR analysis of Agrn and Z+ Agrn expression in rat soleus muscle. Figure S2. Real time RTâÂÂPCR analysis of synaptophysin expression in rat soleus muscle. A (PDF 369 kb
Effect of Dietary Complex Lipids on the Biosynthesis of Piglet Brain Gangliosides
Gangliosides, found in mammalian
milk, are known for their roles
in brain development of the newborn. However, the mechanism involved
in the impact of dietary gangliosides on brain metabolism is not fully
understood. The impact of diets containing complex lipids rich in
milk-derived ganglioside GD3 on the biosynthesis of gangliosides (assessed
from the incorporation of deuterium) in the frontal lobe of a piglet
model is reported. Higher levels of incorporation of deuterium was
observed in the GM1 and GD1a containing stearic acid in samples from
piglets fed milk containing 18.2 Îźg/mL of GD3 compared to that
in those fed milk containing 25 Îźg/mL of GD3. This could suggest
that the gangliosides from the diet may be used as a precursor for
de novo biosynthesis of brain gangliosides or lead to the reduction
of de novo biosynthesis of these gangliosides. This effect was more
pronounced in the left compared to that in the right brain hemisphere