Influence of maturity stage on nutritive value of typha for ruminants

The study evaluated the influence of maturity on the nutritive value and fermentation parameters of Typha. Typha samples were collected at two different stages of growth, as indicated by the height of the plants: either 0.5 m (Low Typha; LT, age 3-6months) or 1.5 m (High Typha; HT, age 9-12 months). Samples were analyzed for chemical composition, and incubated in vitro with ruminal fluid from sheep to determine the main fermentation parameters. As maturity advanced, the dry matter, fiber and lignin content (25.30%, 70.40%, 47.30% and 10.58%) in the Typha increased, whereas the content of ashes and protein (12.18% and 12.24%) decreases. The changes in chemical composition caused a significant reduction in both the in vitro ruminal degradability after 96 h of incubation (38.6 and 22.9% for LT and HT, respectively) and the production of volatile fatty acids after 24 h of incubation (6.08 and 5.87 mmol/g dry matter incubated), indicating that the nutritive value of the Typha declines with advancing maturity. The results indicate that Typha plants for ruminant feeding should be preferably harvested at early growth stages

Early- Onset Stroke and Vasculopathy Associated with Mutations in ADA2

Adenosine deaminase 2 (ADA2) is an enzyme involved in purine metabolism and a growth factor that influences the development of endothelial cells and leukocytes. This study shows that defects in ADA2 cause recurrent fevers, vascular pathologic features, and mild immunodeficiency. Patients with autoinflammatory disease sometimes present with clinical findings that encompass multiple organ systems.(1) Three unrelated children presented to the National Institutes of Health (NIH) Clinical Center with intermittent fevers, recurrent lacunar strokes, elevated levels of acute-phase reactants, livedoid rash, hepatosplenomegaly, and hypogammaglobulinemia. Collectively, these findings do not easily fit with any of the known inherited autoinflammatory diseases. Hereditary or acquired vascular disorders can have protean manifestations yet be caused by mutations in a single gene. Diseases such as the Aicardi-Goutieres syndrome,(2),(3) polypoidal choroidal vasculopathy,(4) sickle cell anemia,(5) livedoid vasculopathy,(6) and the small-vessel vasculitides(7),(8) are examples of systemic ...</p