Contract Pricing and Packer Competition in Fed Cattle Market

We use a game-theoretical framework to analyze the coexistence of spot and contract markets in the cattle industry. A duopsony scenario with two packers and N feeders is used to reflect the reality in the cattle industry. Our main contribution is to incorporate the risk components and the pricing of hedonic attributes of cattle quality. Our preliminary results show that packers have an incentive to transform bidding strategies in spot markets when a series of hedonic characteristics play some significant roles in establishing cattle prices in contract market. That is, we will show that the effectiveness of contract with TOMP clauses on packer competition in a spot market depends on whether there is a correlation between spot price and hedonic characteristics. The results may shed light on understanding potential effects of captive supplies on market power and may aid in the assessment of the policies designed to enhance competition in the cattle industry.Marketing,

Intra-aortic balloon pump (ΙΑΒΡ): from the old trends and studies to the current “extended” indications of its use

This report outlines the well defined indications of using IABP and also favours extending the indications of IABP use, to include not only “therapeutically” the aging unstable patients but also “prophylactically” patients with low EF or high Euroscore

Epstein-Barr virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway

<p>Abstract</p> <p>Background</p> <p>Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, which commonly occurs in Southern China, Taiwan, North Africa and Southeast Asia. Nasopharyngeal carcinoma is strongly associated with Epstein-Barr virus infection. The p53 tumour suppressor protein is rarely mutated in NPC suggesting that the inactivation of p53 pathway in NPC could be due to the presence of EBV proteins. The aim of this work was to determine the effects of EBV proteins namely LMP1 and LMP2A on the expression levels of p53 protein.</p> <p>Findings</p> <p>In this work we found that LMP1, but not LMP2A, decreased p53 protein levels. Overexpression of LMP1 resulted in increased ubiquitination of p53 suggesting that the decreased p53 protein levels by LMP1 was due to increased degradation of the protein. The reduction of p53 protein levels was independent of the PI3K-Akt pathway.</p> <p>Conclusions</p> <p>LMP1, but not LMP2A, reduced p53 protein levels through the increase in the polyubiquitination of p53 protein and was independent of the PI3K-Akt pathway.</p

Pathogenic role of exosomes in Epstein-Barr Virus (EBV)-associated cancers

Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. They contain various pathogenic factors whereby their adverse effects have been implicated in multiple viral infections and cancers. Interestingly, accumulating evidences showed that exosomes derived from tumour viruses or oncoviruses, exacerbate virus-associated cancers by remodelling the tumour microenvironment. In this review, we summarize the contributing factors of Epstein-Barr virus (EBV) products-containing exosomes in viral pathogenesis and their potential implications in EBV-driven malignancies. Understanding the biological role of these exosomes in the disease would undoubtedly boost the development of a more comprehensive strategy to combat EBV-associated cancers and to better predict the therapeutic outcomes. Furthermore, we also highlight the potentials and challenges of EBV products-containing exosomes being employed as diagnostic markers and therapeutic targets for EBV-related cancers. Since these aspects are rather underexplored, we attempt to underline interesting areas that warrant further investigations in the future

A Beaconless Asymmetric Energy-Efficient Time Synchronization Scheme for Resource-Constrained Multi-Hop Wireless Sensor Networks

The ever-increasing number of WSN deployments based on a large number of battery-powered, low-cost sensor nodes, which are limited in their computing and power resources, puts the focus of WSN time synchronization research on three major aspects, i.e., accuracy, energy consumption and computational complexity. In the literature, the latter two aspects have not received much attention compared to the accuracy of WSN time synchronization. Especially in multi-hop WSNs, intermediate gateway nodes are overloaded with tasks for not only relaying messages but also a variety of computations for their offspring nodes as well as themselves. Therefore, not only minimizing the energy consumption but also lowering the computational complexity while maintaining the synchronization accuracy is crucial to the design of time synchronization schemes for resource-constrained sensor nodes. In this paper, focusing on the three aspects of WSN time synchronization, we introduce a framework of reverse asymmetric time synchronization for resource-constrained multi-hop WSNs and propose a beaconless energy-efficient time synchronization scheme based on reverse one-way message dissemination. Experimental results with a WSN testbed based on TelosB motes running TinyOS demonstrate that the proposed scheme conserves up to 95% energy consumption compared to the flooding time synchronization protocol while achieving microsecond-level synchronization accuracy.Comment: 12 pages, 16 figure

Exosomes in Human Immunodeficiency Virus Type I Pathogenesis: Threat or Opportunity?

Nanometre-sized vesicles, also known as exosomes, are derived from endosomes of diverse cell types and present in multiple biological fluids. Depending on their cellular origins, the membrane-bound exosomes packed a variety of functional proteins and RNA species. These microvesicles are secreted into the extracellular space to facilitate intercellular communication. Collective findings demonstrated that exosomes fromHIV-infected subjects sharemany commonalities withHuman ImmunodeficiencyVirus Type I (HIV-1) particles in terms of proteomics and lipid profiles. These observations postulated that HIV-resembled exosomes may contribute to HIV pathogenesis. Interestingly, recent reports illustrated that exosomes from body fluids could inhibit HIV infection, which then bring up a new paradigm for HIV/AIDS therapy. Accumulative findings suggested that the cellular origin of exosomes may define their effects towards HIV-1. This review summarizes the two distinctive roles of exosomes in regulating HIV pathogenesis. We also highlighted several additional factors that govern the exosomal functions. Deeper understanding on how exosomes promote or abate HIV infection can significantly contribute to the development of new and potent antiviral therapeutic strategy and vaccine designs