Regional plots for novel lipid loci with array-wide significant regions in IBC meta-analysis of African ancestry.

<p><b>A.. </b><i>CD36</i> region, <b>B.. </b><i>ICAM1</i> region. Loci are shown as the lead SNP with a flanking region depicting the candidate gene and nearby genes included on the array. The purple diamond represents the lead SNP in the IBC meta-analysis and the dots represent the surrounding SNPs, with the different colors showing the LD relationship with the lead SNP based on YRI HapMap II information. −log10 p-values for association with HDL-C (for <i>CD36</i>) and TC (for <i>ICAM1</i>) are shown for each SNP (left-hand axis). Recombination rates in YRI HapMap II is shown in blue traces (right-hand axis).</p

Schematic design of study for the multi-ethnic IBC-Lipid association meta-analysis.

<p>The workflow includes primary analyses and secondary analyses. Details can be found in the text.</p

Replication results of nine signals in 7,000 African Americans.

<p>RAF risk allele frequency, SE standard error.</p

Loci with significant evidence of independent lipid association signals.

<p>Chr chromosome, BP base pair, RAF risk allele frequency, SE standard error.</p