Boxplot showing distribution of CD3+ cells content in intracranial thrombi by stroke subtypes.

<p>Boxplot showing distribution of CD3+ cells content in intracranial thrombi by stroke subtypes.</p

Patient characteristics and clinical data.

<p>Patient characteristics and clinical data.</p

Number of CD3+ cells in “cardioembolism” and other causes thrombi and in “atherothrombosis” thrombi.

<p>Number of CD3+ cells in “cardioembolism” and other causes thrombi and in “atherothrombosis” thrombi.</p

Hematoxylin and eosin-stained section of a fibrin-dominant thrombus (left) and of an erythrocyte-dominant thrombus (right).

<p>Hematoxylin and eosin-stained section of a fibrin-dominant thrombus (left) and of an erythrocyte-dominant thrombus (right).</p

“Atherosclerotic” thrombus.

<p>CD3+ cells (brown) corresponding to T cells in an “atherosclerotic” thrombus.</p

Number of CD3+ cells in “cardioembolism” thrombi and in “atherothrombosis” thrombi.

<p>Number of CD3+ cells in “cardioembolism” thrombi and in “atherothrombosis” thrombi.</p

Flow Chart.

<p>Study design and flow of participants through the study.</p

Cox proportional-hazard regression models for transition to MCI/dementia during the 7-year follow-up (n = 426, n. of events = 111).

*<p>Cox proportional hazard regression models with delayed entry were performed with age as the basic timescale and birth as the time origin.</p>†<p>In model 5, n = 416 and n. of events = 108.</p

Decision tree (built using the data on total WML volume and on relative WML volume in the frontal, parietal, temporal and occipital regions as potential descriptors).

<p>The three distribution patterns could be used to discriminate between subjects who developed MCI/dementia and subjects who remained cognitively stable. Sensitivity: 29%, specificity: 88%, positive predictive value: 46%, negative predictive value: 78%. Temporal WMLr: (temporal WML volume/total WML volume) ×100.</p

Characteristics of the study participants (n = 426).

¶<p>n = 424.</p>§<p>n = 418.</p