Apprentissage opératoire de la représentation graphique d'une figure volumétrique

Dolle Jean-Marie, Bataillard Alain, Lacroix François. Apprentissage opératoire de la représentation graphique d'une figure volumétrique. In: Bulletin de psychologie, tome 28 n°319, 1975. pp. 956-964

Une approche de l'intuition géométrique au niveau de l'intelligence opératoire formelle

Dolle Jean-Marie, Bataillard Alain, Gravelle Maurice, Lacroix François. Une approche de l'intuition géométrique au niveau de l'intelligence opératoire formelle. In: Bulletin de psychologie, tome 33 n°345, 1980. Approches de l'adolescence /Les opérations cognitives et leur développement. pp. 719-731

Oxidation of PAHs and their by-products (polar PACs) in the saturated zone of DNAPL-contaminated sub-soils after pumping

International audienc

Mapping the Genetic Determinants of Hypertension, Metabolic Diseases, and Related Phenotypes in the Lyon Hypertensive Rat

The complex nature of hypertension makes identifying the pathophysiology and its genetic contributions a challenging task. One powerful approach for the genetic dissection of blood pressure regulation is studying inbred rat models of hypertension, as they provide natural allele variants but reduced heterogeneity (both genetic and etiologic). Furthermore, the detailed physiologic studies to which the rat is amenable allow for the determination of intermediate phenotypes. We have performed a total genome scan in offspring of an F 2 intercross between the Lyon hypertensive (LH) and Lyon normotensive rat strains to identify linkage of anthropometric, blood pressure, renal, metabolic, and endocrine phenotypes. Quantitative trait locus (QTL) regions involved in blood pressure regulation, end-stage organ damage, body and organ weight, and lipid metabolism in the LH rat were identified on chromosomes 1, 2, 3, 5, 7, 10, 13, and 17, with 2 phenotypes associated with the metabolic syndrome identified on chromosomes 1 and 17. Regions on chromosomes 2, 13, and 17 were revealed to be important for blood pressure regulation. Regions on chromosome 17 were found to significantly contribute to both metabolic homeostasis and blood pressure regulation; 2 aggregates of a total of 23 QTLs were identified, including several “intermediate phenotypes.” These intermediate phenotypes may be used as closer surrogates to the mechanisms leading to hypertension and metabolic dysfunction in the LH rat