Centralised Versus Market-Based Control Under Environment Uncertainty: Case of the Mobile Task Allocation Problem (MTAP)

This paper aims at comparing the centralised versus the market-based approach. This is done in the context of the mobile task allocation problem (MTAP) from the perspective of environmental uncertainty. MTAP is defined as an optimization problem for planning the assignment of service tasks to mobile workers. Environmental uncertainty is introduced through the injection of stochastic tasks and dynamic travel delays. A multi-agent simulator is employed to experiment the behaviour of each approach in reaction to different uncertainty levels. Preliminary results suggest a tentative conceptual model to evaluate the suitability of each approach to address MTAP in function of uncertainty. It is suggested that uncertainty’s effect on achieved performance is moderated by the timeliness of decision making, workers’ degree of local knowledge, and problem’s complexity and size

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

Copyright © 2014 Al-Mahdawi, Anjomani Virmouni and Pook. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.This article has been made available through the Brunel Open Access Publishing Fund.DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC) modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important epigenetic mark that is involved in the control of gene transcription for processes such as development and differentiation. However, recent studies have identified an alternative modification, 5-hydroxymethylcytosine (5hmC), which is formed by oxidation of 5mC by ten-eleven translocation (TET) enzymes. The overall levels of 5hmC in the mammalian genome are approximately 10% of 5mC levels, although higher levels have been detected in tissues of the central nervous system (CNS). The functions of 5hmC are not yet fully known, but evidence suggests that 5hmC may be both an intermediate product during the removal of 5mC by passive or active demethylation processes and also an epigenetic modification in its own right, regulating chromatin or transcriptional factors involved in processes such as neurodevelopment or environmental stress response. This review highlights our current understanding of the role that 5hmC plays in neurodegenerative diseases, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), fragile X-associated tremor/ataxia syndrome (FXTAS), Friedreich ataxia (FRDA), Huntington's disease (HD), and Parkinson's disease (PD).Sara Anjomani Virmouni was supported by funding to Mark A. Pook from the Friedreich’s Ataxia Research Alliance(FARA)

Sampling and interpolation in Hilbert spaces of entire functions

Sampling theory is the study of spaces of functions which are reconstructible from their values at certain sets of points, which gives rise to a sampling formula for the underlying space. For this, it is necessary to consider spaces of functions whose values at a set of points are well-defined. In this work we consider the sampling and interpolation problems in reproducing kernel Hilbert space of entire functions, called de Branges space. Functions in such space are square integrable on the real line with respect to some weight function, and satisfying some growth conditions. Some sampling and interpolation results in the Paley-Wiener spaces, which are a primary example of de Branges spaces, are reviewed. We develop necessary conditions for sampling and interpolating sequences which generalize some well-known sampling and interpolation results in the Paley-Wiener space. The proofs of the necessary conditions rely very much on the Homogeneous Approximation Property and the Comparison Theorem that we prove in de Branges space. We also give necessary and sufficient conditions for Plancherel-Polya sequences, and sufficient conditions for interpolation in some de Branges spaces of exponential type

Palladium(II) saccharinate complexes trans-[Pd(sac)(2)(LH)(2)] with amino- and acetylamino-pyridine co-ligands: molecular structures of trans-[PdCl2(2-ampyH)(2)].2dmf (2-ampyH=2-amino-3-methylpyridine) and trans-[Pd(kappa(2)-2-acmpy)(2)] (2-acmpyH=2-acetylamino-3-methylpyridine)

Reaction of Na2[PdCl4] with two equivalents of amino- or acetylamino-pyridines (LH) affords trans-[PdCl2-(LH)2] {LH = 2-amino-3-methylpyridine (2-ampyH), 3-aminopyridine (3-apyH), 2-acetylamino-3-methylpyridine (2-acmpyH), 3-acetylamino-pyridine (3-acpyH)}. An X-ray crystal structure of trans-[PdCl2(2-ampyH)2] shows that the 2-ampy-H ligands are coordinated in a monodentate fashion via the nitrogen atoms of the pyridine rings. Treatment of trans-[PdCl2(2-acmpyH)2] with NEt3 affords the cyclometalated complex, trans-[Pd(κ2-2-acmpy)2], the X-ray structure of which shows that the 2-acmpy ligand is coordinated to palladium in a bidentate fashion via the nitrogen atom of the pyridine ring and oxygen. Reaction of trans-[PdCl2(LH)2] with two equivalents of sodium saccharinate affords the bis(saccharinate) complexes, trans-[Pd(sac)2(LH)2], in which the saccharinate anions are coordinated via the amide nitrogen atom

Hepatic haemangioma: A Case Report and Review of Literature

No Abstract

Undispensed Prescriptions due to Drug Unavailability at a Teaching Hospital in Saudi Arabia

Purpose: To describe the extent of undispensed prescriptions as a result of drug unavailability in a tertiary health facility in Saudi Arabia Methods: This study was conducted prospectively in a large teaching hospital over a 6 months period from May to October of 2005 and tracked 14 commonly prescribed drugs. The bimonthly drug requisition forms and the amount supplied by medical supply department (MSD) were collected and reviewed. Results: Total number of prescriptions issued for the drugs under examination was 29113. 26551 prescriptions were dispensed while the remaining 2562 (9%) were undispensed due to drug unavailability. The difference between quantity of drugs requested by the pharmacy and quantity issued from MSD was 47-52%. Conclusion: Mismatch between drug demand and supply in the facility studied is the main cause of shortage.Keywords: Drug prescriptions, inventory management, hospital pharmac

The Sustainable Development of Sub-Khao Phanom Dong Rak with Special Reference to the Sangha’s Education

This article’s purposes were 1) to present basic information of the Phanom Dong Rak civilization, 2) to study Buddhism in sub- Khao Phanom Dong Rak, and 3) to examine the monastic study for proposing a sustainable development approach in sub-Khao Phanom Dong Rak. This relies on the main source of data used in the documentary research. The methodology adopted in the study is of a critical and investigative approach to the analysis of data gathered from documentary sources. The result indicated that: The Phanom Dong Rak, which is used in the Thai language. It is a mountain located in the southeastern part of Thailand as the border between Thailand and Cambodia, starting from the Khorat Plateau, stretching to the east to the Prasat Wat Phu in Champasak, Laos. On both sides of Phanom Dong Rak, shows signs of embarrassment that have existed in the past 3,000 years ago, and there are still many ethnic groups inhabiting the particles of the Phanom Dong Mountains. The sustainable development of sub-Khao Phanom Dong Rak should integrate work according to the “Borworn” principle, namely “families, temples, government or schools” of all three countries in Phanom Dong Rak mountain rang

The Value of the Buddhist Art as depicted the Khmer Castles in Surin Province

The purposes of this article were 1) to present the Buddhist art as depicted in the Khmer castles, to examine the valueof Buddhist art as depicted in the Khmer castles. Historical documents and archaeological evidence were used. The resultindicated that: When Buddhism was spread into the Suvarnabhumi region during the 3rd century AD, there was a devotee anddedication to create art related to Buddhism. Thus, this art is called Buddhist art. Among all the important civilizations in thisworld, the Khmer civilization, which is one of the important civilizations in Southeast Asia. The forms of Khmer architecture orLopburi architecture can be divided into 3 types: (1) Devalai or temple (2) Dhammasala, accommodation for travelers, or houseswith lights (3) Arogayasala (Chapel of the hospital). Surin province is located in the northeast of Thailand. There are a largenumber of Khmer castles. In this province, the castles of Brahmanism and Buddhism had been settled. The Buddhist arts hadreflected through architecture. It was indicated that this area used to have Mahayana Buddhism. Although the Buddhist Mahayanasect at present has deteriorated. Historical evidence and values still exist nowaday