Immunohistochemical expression of CD 14 in transitional cell carcinoma of the urinary bladder

CD14 is a co-receptor for bacterial lipolysaccharide (LPS) detection. It is found on myelomonocytic cells such as monocytes, macrophages, and Langerhans cells, CD14 expression in bladder cells is necessary for cytokine secretion and increased tumor growth. The goal of this study was to use immunohistochemistry (IHC) to assess CD14 expression in patients with transitional cell carcinoma of the urinary bladder in order to see if there was a link between CD14 marker expression in bladder cancer and cystitis. The immunoexpression of CD14 in paraffin sections from 30 bladder biopsy samples was separated into three groups: cystitis, low grade bladder cancer (L.G), and high grade bladder cancer (H.G), and studied using immunohistochemical assays (IHC). For bladder cancer (L.G & H.G), the percentage of samples that gave positive results for IHC/CD14 expression was 70% and 80%, respectively, compared to 30% for cystitis. The incidence of study samples appear in both sexes

Immunohistochemical Expression of CD 14 in Transitional Cell Carcinoma of the Urinary Bladder

CD14 is a co-receptor for bacterial lipolysaccharide (LPS) detection. It is found on myelomonocytic cells such as monocytes, macrophages, and Langerhans cells, CD14 expression in bladder cells is necessary for cytokine secretion and increased tumor growth. The goal of this study was to use immunohistochemistry (IHC) to assess CD14 expression in patients with transitional cell carcinoma of the urinary bladder in order to see if there was a link between CD14 marker expression in bladder cancer and cystitis. The immunoexpression of CD14 in paraffin sections from 30 bladder biopsy samples was separated into three groups: cystitis, low grade bladder cancer (L.G), and high grade bladder cancer (H.G), and studied using immunohistochemical assays (IHC). For bladder cancer (L.G & H.G), the percentage of samples that gave positive results for IHC/CD14 expression was 70% and 80%, respectively, compared to 30% for cystitis. The incidence of study samples appear in both sexes

Role of some proteins in resistance of clinical Acinetobacter baumannii isolates to imipenem

Acinetobacter baumannii is one of the ESKAPE pathogens which are the leading cause of nosocomial infections throughout the world. The aim of this study is to detect the role of Some Proteins in Resistance of Acinetobacter baumannii to imipenem. The research included the collection of 100 different clinical specimens of( urine, burns, and wounds) isolated from patients in Al-Diwaniyah Teaching Hospital for the period from September to December 2021. 20 isolates out of 100 isolates belonging to A.baumannii  were obtained. The samples were collected from different clinical specimens distributed as follows:7(35%) Swabs of burns,8(40%) swabs of wounds, and 5(25%)from urine, an examination was conducted for (8)Antibiotics by ( Antibiotic Susceptibility Test-AST ) on 20  isolates. The results showed that all isolates are resistant to antibiotics except for imipenem showed a sensitivity of 20% and resistance of 80% to imipenem. The results of the Minimum Inhibitory Concentration level of imipenem that were conducted for five isolates showed that all isolates are resistant to imipenem at concentrations of (128 mg/ml and 256 mg/ml ), while  2(40%) isolates out of 5 isolates were resistant to imipenem in the concentration of 64 mg /ml.&nbsp