Histopathological Study of Sub- Acute Toxiciy Induced by Relife in Mature Male Rats

           هدف العمل الحالي الى دراسة التغيرات الامراضية السمية الحادة للتسمم بامراض الرليف في ذكور الجرذان البالغة . استخدم في الدراسة (30) جرذ وبعمر (10) اسابيع واوزان تراوحت بين (60-120) غم حيث قسمت مجموعتين  متساوتين وكما يأتي: المجموعة الاولى جرعت ماء مقطر لمدة 30 يوم  وعدت مجموعة سيطرة، المجموعة الثانية جرعت 500ملغم /كغم من وزن الجسم من قرص واحد للرليف (يتكون من ديكلوفينات الصوديوم 50 ملغم ,الباراسيتامول  500 ملغم ,كلورومفينيرامين ماليت 4 ملغم و المغنسييوم ثلاثي السليكات 100ملغم ) مذاب في 10مل ماء مقطر.تم اخذ عينات من والكبد والكلية و الخصى و البربخ و الدماغ و الطحال  لغرض اجراء الفحوصات المرضية النسجية.اوضحت النتائج حصول تغيرات امراضية نسجية قوية في الاعضاء الماخوذة نتيجة للتسمم تحت الحاد للرليفThe present work was conducted to study the sub-acute  toxicopathological changes of relief in  mature male rats . Thirty male rats aged (10) weeks and weighted  (60 -120) gm were divided equally into (2) groups as follows: Group I: Rats served as control group and received distilled water for 30 days . Group II: Rats served as experimental group  and received (by gavage 500 mg  /kg b.w ) one tablets of relief (composed of Diclofence sodium 50mg , paracetamol 500 mg ,chlorpheniramine  malete 4 mg and magnesium trisilicate 100 mg ) diluted in 10 ml of distilled water . Specimens from, liver, kidneys, testes, epididymis ,brain and  spleen, were dissected out for histopathological examination. Results showed severe histopathological changes in all selected tissues as  a results of sub acute toxicity of relief tablets.  &nbsp

Effect of long-term administration of Atonik compound in female rabbits on hematological and pathological changes in important functional body organ

Objectives This study includes the investigation of stimulant plant growth compound Atonik’s harmful effect in some important function of body organs of rabbits. Methods Twelve female rabbits weighting 1.4–1.6 kg were obtained from animal house in the college of Veterinary Medicine and they were housed for 2 weeks before the beginning of study and all laboratory condition were taken into consideration. Animals were randomly divided into two main groups: Control group without treatment at all periods of study, Atonik group: each rabbit was orally received 0.1 mg/kg/three time weekly (TIDW) and study was persistent for eight weeks. Results Our result reveals the disturbance of hematological parameters specially WBCS, RBCS, HB and lymphocyte. Moreover, histopathological section showing dilation of the central vein filled with fluid and granuloma beside it with vaculation of hypatocyte. The kidney reveals coagulative necrosis of renal tubules with the distraction of glomerular tuft. Uterus of rabbits treated with 0.1 mg/kg bw atonik for 8 weeks showing necrosis of unrein glands. Ovary showed an increase in the numbers of atretic follicles. Our result concluded that atonik has a very harmful effect for reproduction, liver and kidney. Conclusion Use of atonik plant growth hormones reveal very harmful effect in reproductive and functional organ of rabbits, In addition to that, limited use of atonik hastens plant growth specially fruits such as figs, which is characteristic with low maturity period that should be used with safety period at least 2 weeks