CT evaluation of malignant PNS mass and histopathological correlation

Background: Computed tomography (CT) is the gold standard for exact delineation of paranasal sinus(PNS) disease. There are many radiologically important diseases of paranasal sinuses. Objective: to evaluate the malignant PNS mass by computed tomographic image and the findings of this modality were compared with histopathological result.Methods: It was a cross sectional type of study and carried out with suspected PNS mass having patients during January 2009 to Octo­ber 2010.Results: The mean age of the patients was 35.95 ± 18.24 and common complaints of the patients were nasal obstruction (73.7%) and maximum 53.9% patients had PNS mass in maxillary sinuses. Out of 76 cases 21.1 % found malignant mass on CT and after histopathology 19. 7% had malignant mass. Out of all cases 14 were diagnosed as malig­nant PNS mass by CT scan and confirmed by histopathological evaluation and they were true positive. Two cases were diagnosed as malignant PNS mass by CT scan but not confirmed by histopathological findings and they were false positive. Of 60 cases, which were diagnosed by CT scan, one was confirmed as malignant and 59 were benign by histopa­thology. They were false negative and true negative respectively. Sensitivity of CT scan to diagnose malignant PNS mass was 93.3%, specificity 96.7%, positive predictive value 87.5%, negative predictive value 98.3% and accuracy 96.1 %. Conclusion: CT scan of the malignant para nasal sinus mass provides more information and better image quality and CT diagnosis correlate well with the findings of histopathology

CT evaluation of malignant PNS mass and histopathological correlation

Background: Computed tomography (CT) is the gold standard for exact delineation of paranasal sinus(PNS) disease. There are many radiologically important diseases of paranasal sinuses. Objective: to evaluate the malignant PNS mass by computed tomographic image and the findings of this modality were compared with histopathological result. Methods: It was a cross sectional type of study and carried out with suspected PNS mass having patients during January 2009 to Octo­ber 2010. Results: The mean age of the patients was 35.95 ± 18.24 and common complaints of the patients were nasal obstruction (73.7%) and maximum 53.9% patients had PNS mass in maxillary sinuses. Out of 76 cases 21.1 % found malignant mass on CT and after histopathology 19. 7% had malignant mass. Out of all cases 14 were diagnosed as malig­nant PNS mass by CT scan and confirmed by histopathological evaluation and they were true positive. Two cases were diagnosed as malignant PNS mass by CT scan but not confirmed by histopathological findings and they were false positive. Of 60 cases, which were diagnosed by CT scan, one was confirmed as malignant and 59 were benign by histopa­thology. They were false negative and true negative respectively. Sensitivity of CT scan to diagnose malignant PNS mass was 93.3%, specificity 96.7%, positive predictive value 87.5%, negative predictive value 98.3% and accuracy 96.1 %. Conclusion: CT scan of the malignant para nasal sinus mass provides more information and better image quality and CT diagnosis correlate well with the findings of histopathology

An experimental analysis of different point specific musculoskeletal pain among selected adolescent-club cricketers in Dhaka City

Introduction. Musculoskeletal disorders (MSDs) are considered to be among the most stressful events of human body considering their onset, symptoms and the ultimate consequences. Aim. This study was conducted to provide a concise overview of cricket-related musculoskeletal pain of the upper limb and lower limb region in male adolescent cricketers. Material and methods. Data was collected from three clubs in Dhaka city, and the participant’s age group was 10-19 years. Data was collected through oral conversations with participants and physical testing. This process was continued over six months, which repeated monthly between same subjects. Results. 97 cricketers experienced musculoskeletal pain, where maximum reported upper limb musculoskeletal pain was 33.3% shoulder, 21.6% elbow, 27.5% wrist, and 17.6% hand pain. In contrast, 46 candidates were found in the lower limb musculoskeletal pain category containing 19.6%, 30.4%, 30.4% and 19.6% hip joint, knee joint, ankle joint and foot joint musculoskeletal pain, respectively. BMI had no significant effect on the typical upper and lower limb musculoskeletal pain. Batsmen playing for 4 sessions or more per week are the main victims of upper limb musculoskeletal pain. In contrast, bowlers and all-rounders were the main victims of lower limb musculoskeletal pain under similar workloads. Conclusion. This study reflects an up-to-date overview of regional upper limb and lower limb musculoskeletal pain where the risk of lower limb injury is most common among all types of players

FACTORIAL ANALYSIS OF THE REASONS OF TYPE 2 DIABETES MELLITUS FROM THE SELECTED URBAN AND RURAL SUBJECTS OF BANGLADESH

Background Type 2 Diabetes Mellitus has been a major concern for the people of Bangladesh where various factors are risky in this regard. That’s why the study was designed in a way to assess the risk factors. Materials and methods Sixty subjects played a part in the study of 30-90 years old, were branded into four varied groups. A number of factors including age, height, weight status, smoking habits, calorie intake, physical activity and past medical history were analyzed. Both BMI and FBG level were correlated. Results BMI status advocates that obese subjects of Group-1 (80%) and Group-4 (66.67%) higher than 50% whereas group-2 (26.67%) and group-3 (46.67%) contains obese subjects below 50%. According to FBG level, Group-1 (average 16.876 mmol/L) and Group-4 (average 14.12 mmol/L) were in high risk than Group-2 (average 7.265 mmol/L) and Group-3 (10.03 mmol/L) subjects. 45% subjects had a family history of diabetes and about 50% male smokers were obese. 95% of subjects didn’t have any physical exercise. The rate of new patients with no family history is increasing (48.33%). Conclusion This study states individual correlation between BMI & FBG. Food calorie intake condition, data related to obesity and family history were also calculated

A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells

Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible for the maintenance of the cancer phenotype; this unique feature in cancer cells may, therefore, be exploited for targeted therapy. Quercetin (QC), a plant-derived bioflavonoid, is known for its ROS scavenging properties and was recently discovered to have various antitumor properties in a variety of solid tumors. Adaptive stress responses may be induced by persistent ROS stress, allowing cancer cells to survive with high levels of ROS while maintaining cellular viability. However, large amounts of ROS make cancer cells extremely susceptible to quercetin, one of the most available dietary flavonoids. Because of the molecular and metabolic distinctions between malignant and normal cells, targeting ROS metabolism might help overcome medication resistance and achieve therapeutic selectivity while having little or no effect on normal cells. The powerful bioactivity and modulatory role of quercetin has prompted extensive research into the chemical, which has identified a number of pathways that potentially work together to prevent cancer, alongside, QC has a great number of evidences to use as a therapeutic agent in cancer stem cells. This current study has broadly demonstrated the function-mechanistic relationship of quercetin and how it regulates ROS generation to kill cancer and cancer stem cells. Here, we have revealed the regulation and production of ROS in normal cells and cancer cells with a certain signaling mechanism. We demonstrated the specific molecular mechanisms of quercetin including MAPK/ERK1/2, p53, JAK/STAT and TRAIL, AMPKα1/ASK1/p38, RAGE/PI3K/AKT/mTOR axis, HMGB1 and NF-κB, Nrf2-induced signaling pathways and certain cell cycle arrest in cancer cell death, and how they regulate the specific cancer signaling pathways as long-searched cancer therapeutics