The non-coding RNA landscape of plasma cell dyscrasias

Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future

Evaluation of in vitro and in vivo Cytotoxic Activities and Kinase Inhibition of Newly Synthesized Cyclo (Nα-Dinicotinoyl)-Bis-[(L-Valinyl)-L-Lysine Methyl Ester]

222-225Cancer is a major risk disease affecting human survival. The pharmaceutical companies are continuing searching for new drug candidates with promising anticancer activities, and reduced side effects. The current work aimed at synthesized a new tripeptide with potential pharmacological properties. L-Valine methyl ester was used to prepare cyclo (Nα-dinicotinoyl)-bis-[(L-valinyl)-L-lysine methyl ester. The new compound revealed promising in vitro cytotoxic activities against different neuroblastoma, cervical carcinoma, fibrosarcoma as well as hepatocellular carcinomas. Furthermore, we also found that the obtained IC50 of the compound decreased by about 50% during its in vivo anti-prostate cancer evaluation. Furthermore, the mechanism of action studies proposes that the new prepared derivative affects cancer cells trough the inhibition of VEGFR-2 kinase enzyme

A Quantitative Approach to Estimate the Damage Inflicted by Traffic Pollution on Historic Buildings in Al-Salt City, Jordan

Traffic in the city of Al-Salt is not only putting pedestrians at risk and threatening the health of citizens, it is also damaging the town's historic buildings. Most stone buildings in the heritage-rich city are suffering adverse effects from vehicle-related pollution. This effect is highly visible soiling and discoloration from deposited carbon particles in the form of fine soot on most buildings. The level and progress of the damage depends on the geology of the stone and the proximity of the structure from traffic congestion. The accumulation of soot leads to the buildup of black sulfate (gypsum) skins on the limestone facade which causes the sound stone behind it to disintegrate. It is vital to the well-being of this historic treasure that the volume of the city traffic must be reduced and traffic flow improved. The main objective of this study is to qualitatively and quantitatively assess the damage caused to buildings of historical and cultural value by traffic pollution. Age of vehicles running on city’s streets and the rate of their emissions are quantified and analyzed. Several field investigations and laboratory tests were conducted to identify the chemical relations between pollutants and stone decay on these buildings. Keywords: Traffic pollution, tailpipe emission, vehicular emission, historic buildings, limeston

The Jurisprudential Criticism of Imam Al-Izz Bin Abd Al-Salam in His Book “The Rules of Judgments in the Interests of the People”

Imam al-Izz ibn Abd al-Salam had a place at the top of the pyramid of jurisprudence in general and al-Shafi’i in particular. Senior jurists are of that rank, and the nation is unanimous in their acceptance and acceptance of their jurisprudential product, which cannot be separated from it and that heritage for the sake of renewal or to keep pace with the other. I am talking here about the men of the four recognized schools of jurisprudence. Among those sects was the Shafi’i school of thought, and this study came to shed light on the jurisprudential criticism that the imam dealt with in his well-known and famous book: “The Rules of Judgments in the Interests of People.” This is the jurisprudential criticism that he not only directed to the great jurists of different sects, but also extended his criticism to the jurisprudence school that he adopts and adopts, which is the Shafi’i school. And when those scattered jurisprudential criticisms abounded in this useful book - which I made the focus of research -, and those criticisms were direct and direct to the adherents of the sects from an imam who is attested by everyone who has consideration in the sciences of jurisprudence and its origins, we can through all of this deduce the importance of analyzing and discussing some of them possible in this study. It was through the descriptive inductive method

Transient MHD Double-Diffusive Natural Convection over a Vertical Surface Embedded in a Non-Darcy Porous Medium

The problem of transient, laminar, MHD double-diffusive free convection over a permeable vertical plate embedded in Darcy and non-Darcy porous medium is numerically investigated. Nonsimilarity solutions are obtained for constant wall temperature and concentration with a specified power law of mass flux parameter. The effects of the magnetic parameter, the inertial coefficient, Lewis number, the buoyancy ratio, and the lateral mass flux on heat and mass transfer coefficients are presented and discussed

Acacia senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity

Cylophosphamide (CYCL) is a strong anticancer and immunosuppressive agent but its urotoxicity presents one of the major toxic effects that limit its wide usage particularly in high dose regimens. Therefore, this study aimed to investigate Acacia Senegal gum exudate, Gum Arabic (GA), for its possible role as a natural, nontoxic agent against CYCL-induced urotoxicity. Male Swiss albino rats were exposed to CYCL (150 mg/kg BW, once i.p) with or without GA oral supplementation (7.5 g/kg/day for 6 days) through drinking water. Glutathione (GSH), Malondialdehyde (MDA) and Nitric oxide (NO) bladder contents were assessed. Responsiveness of the bladder rings to acetylcholine (ACh) in vitro, microscopic and macroscopic features are also investigated. CYCL produced pronounced harmful effects on bladder urothelial lining with significant increases in (MDA) and NO levels in the tissue homogenates. Bladder-GSH content is dropped by over 60% following CYCL injection. Bladder contractility, as measured by its responsiveness to ACh, recorded a marked reduction. The isolated bladders exhibited such macroscopic changes as severe edema, inflammation and extravasation. The bladder weight increased as well. Histological changes were evident in the form of severe congestion, petechial hemorrhage and chronic inflammatory reaction in the lamina propria accompanied with desquamated epithelia. GA, a potential protective agent, produced an almost complete reversal of NO induction, lipid peroxidation or cellular GSH bladder contents in the GA + CYCL-treated group. Likewise, bladder inflammation and edema were reduced. Bladder rings showed a remarkable recovery in their responsiveness to ACh. Bladder histological examination showed a near normal configuration and structural integrity, with a significant reduction in inflammation and disappearance of focal erosions. These remarkable effects of GA may be attributed to its ability to neutralize acrolein, the reactive metabolite of CYCL and/or the resultant reactive oxygen metabolites, through a scavenging action. GA may limit the cascading events of CYCL-induced damage, initiating a cytoprotective effect leading to structural and functional recovery of the bladder tissues

Empowering Women Between Justice and Equality Between Islamic Law and International Covenants (Reference Study)

This study aims to explain the concepts of equality in Islamic Sharia, clarify them, and ensure that women find their full rights within a just law legislated by God Almighty. In the past, women in Western countries suffered from injustice under man-made legislation, which led to demands for their rights resulting in narrow equality between them and men, which was not fair. The study concluded that the term empowerment was closest to the aspect of equality but neglected the role and function of men in society, which is not permitted by Islamic law. Islamic law provides equal rights and duties to both genders, guided by the balance of justice that God Almighty has prescribed. The researchers recommend discussing the concept of empowerment in Islamic law compared to what is stated in international agreements and womens rights organizations through conferences and modern means of communication