Efficacy of using a dual layer of membrane (d PTFE placed over collagen) for ridge preservation in fresh extraction sites: a micro‐computed tomographic study in dogs

Objective To assess if overbuilding the buccal plate or using a dual‐layer socket grafting technique prevents alveolar bone resorption and enhances final ridge width, height, and volume after tooth loss in an animal model. Material and methods In eight beagle dogs bilateral second (P2)‐, third (P3)‐, and fourth (P4) premolars were endodontically treated. All bilateral mandibular first premolars and distal roots of P2, P3, and P4 were hemisectioned and atraumatically extracted. Animals were randomly divided into four groups: (i) Control–Socket alone, (ii) Particulate allograft in the alveolum, socket covered with high‐density polytetrafluoroethylene ( dPTFE ) membrane and sutured over the alveolum, (iii) Particulate allograft in the alveolum and overbuilding the buccal plate, socket covered with dPTFE membrane and sutured over the alveolum, (iv) Particulate allograft in the alveolum and covered with dual layer ( dPTFE placed over collagen membrane), and sutured over the alveolum. After 16 weeks, the animals were sacrificed. Mandibular blocks of the jaws were assessed for bone volume ( BV ), vertical bone height ( VBH ), alveolar ridge thickness, and bone mineral density ( BMD ) using micro‐computed tomography. Results The BV in groups 1, 2, 3, and 4 was 169.5, 207.57, 242.4, and 306.1 mm 3 , respectively. The VBH in groups 1, 2, 3, and 4 was 4.2, 6.4, 6.2, and 7.3 mm, respectively. Ridge widths in groups 1, 2, 3, and 4 were 5.45 ± 0.75, 5.91 ± 0.86, 6.05 ± 0.63, and 6.28 ± 1.01 mm, respectively. There was no significant difference in BMD between the groups. Conclusions The RP using a dual layer of membrane following tooth extraction results in more BV , VBH , and alveolar ridge width as compared to when a single layer of membrane is used.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100133/1/clr2526.pd

Efficacy of Using PDGF and Xenograft With or Without Collagen Membrane for Bone Regeneration Around Immediate Implants With Induced Dehiscenceâ Type Defects: A Microcomputed Tomographic Study in Dogs

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141676/1/jper0371.pd

Efficacy of Acellular Dermal Matrix and Coronally Advanced Flaps for the Treatment of Induced Gingival Recession Defects: A Histomorphometric Study in Dogs

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141958/1/jper1172.pd

Effects of Recombinant Human Bone Morphogenetic Proteinâ 2 on Vertical Bone Augmentation in a Canine Model

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141765/1/jper0896.pd

Wnt4 Signaling Prevents Skeletal Aging and Inflammation by Inhibiting Nuclear Factor-κB

Aging-related bone loss and osteoporosis affect millions of people worldwide. Chronic inflammation associated with aging promotes bone resorption and impairs bone formation. Here we show that Wnt4 attenuates bone loss in osteoporosis and skeletal aging mouse models by inhibiting nuclear factor-κB (NF-κB) via noncanonical Wnt signaling. Transgenic mice expressing Wnt4 from osteoblasts were significantly protected from bone loss and chronic inflammation induced by ovariectomy, tumor necrosis factor or natural aging. In addition to promoting bone formation, Wnt4 inhibited osteoclast formation and bone resorption. Mechanistically, Wnt4 inhibited NF-κB activation mediated by transforming growth factor-β–activated kinase-1 (Tak1) in macrophages and osteoclast precursors independently of β-catenin. Moreover, recombinant Wnt4 alleviated bone loss and inflammation by inhibiting NF-κB in vivo in mouse models of bone disease. Given its dual role in promoting bone formation and inhibiting bone resorption, our results suggest that Wnt4 signaling could be an attractive therapeutic target for treating osteoporosis and preventing skeletal aging

Is there a gender difference in anatomic features of incisive canal and maxillary environmental bone?

Objectives The effect of gender on anatomic structures and various body systems were illustrated in the literature. The purpose of this study was to identify the influence of gender and tooth loss on incisive canal characteristics and buccal bone dimensions in the anterior maxilla. Materials and methods Computed tomographies ( CTs ) of 417 male and 516 female patients in four dental clinics were included in this study. The diameter and the length of the incisive canal; width and the length of the bone anterior to the canal; palatal bone length, root length, and root width of the central incisor teeth were measured and recorded from CT sections. Results Mean incisive canal length was 11.96 ± 2.73 mm and 10.39 ± 2.47 mm in men and women, respectively, ( P  < 0.05). In men, mean canal diameter was 2.79 ± 0.94 mm whereas in women it was 2.43 ± 0.85 mm and this difference was statistically significant ( P  < 0.05). Men had significant higher buccal bone dimensions (length and width of the bone anterior to the canal) than women. Absence of teeth in the anterior maxilla decreased incisive canal length and buccal bone dimensions; however, canal diameter remain unchanged. Conclusions Present results suggested a gender related differences in anatomic features of incisive canal and surrounding buccal bone. In addition, crestal canal diameter, buccal bone length, and thickness parameters might be different in distinct countries.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99051/1/clr2493.pd

Evaluation of Maxillary Incisive Canal Characteristics Related to Dental Implant Treatment With Computerized Tomography: A Clinical Multicenter Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141666/1/jper0337.pd