Analysis of resting heart rate and clinical characteristics in outpatients with stable coronary artery disease in Turkey: PULSE study

Background: An association between resting heart rate (RHR) and cardiovascular morbidity and mortality has been shown in patients with coronary artery disease (CAD). We aimed to evaluate the RHR and its relationship with clinical variables in outpatients with stable CAD at secondary and tertiary care centers in Turkey. Methods: Adults with stable CAD in sinus rhythm were included in this non-interventional, national, cross-sectional, multicenter study. Data were collected at a single study visit from 83 centers. Results: The mean ± standard deviation age of all patients (n = 2,919) was 61 ± 10 years and 73% were males. The mean (SD) RHR was 73 ± 12 bpm, and 62% of patients had RHR of ≥ 70 bpm. Females more frequently had RHR ≥ 70 bpm compared with males (67% vs. 60%; p = 0.002). RHR was significantly higher in patients with angina than in those without (76 ± 13 vs. 73 ± 11 bpm, p < 0.001). Left ventricular ejection fraction and heart rate lower­ing drug use were significantly lower in patients with a RHR ≥ 70 bpm (p < 0.05). Conclusions: The RHR of outpatients with stable CAD was not within the level recommended by the guidelines.

Analysis of resting heart rate and clinical characteristics in outpatients with stable coronary artery disease in Turkey: PULSE study

Background: An association between resting heart rate (RHR) and cardiovascular morbidity and mortality has been shown in patients with coronary artery disease (CAD). We aimed to evaluate the RHR and its relationship with clinical variables in outpatients with stable CAD at secondary and tertiary care centers in Turkey

Analysis of resting heart rate and clinical characteristics in outpatients with stable coronary artery disease in Turkey: PULSE study.

Background: An association between resting heart rate (RHR) and cardiovascular morbidity and mortality has been shown in patients with coronary artery disease (CAD). We aimed to evaluate the RHR and its relationship with clinical variables in outpatients with stable CAD at secondary and tertiary care centers in Turkey

Frequency of angina and quality of life in outpatients with stable coronary artery disease in Turkey: insights from the PULSE study

Objective Cardiologists'approach to angina in outpatients with stable coronary artery disease (CAD) is unclear. Therefore, we analysed data from the national multicentre, observational PULSE study to evaluate the frequency of angina, clinical variables affecting angina frequency and the impact of frequent angina on quality of life (QoL) in outpatients with stable CAD managed by cardiologists in secondary and tertiary health-care centres in Turkey

Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia

Background and Aims: In recent years, there has been an increased interest in the search for herbs to aid the management of hyperlipidemia. There is currently very little data on the simultaneous evaluation of the antioxidant and prooxidant properties of antihyperlipidemic herbs. This study was designed to evaluate the antioxidant and prooxidant properties of four antihyperlipidemic herbal drugs and also of bergamot. Methods: Antioxidant property was determined by ferric ions (Fe3+) reducing capacity (IRC), DPPH radical scavenging activity (DPPH IC50) and trolox equivalent antioxidant capacity (TEAC); deoxyribose degradation test was used for prooxidant property. Results: The highest total phenolic content (TPC) was in the myrtle leaf (ML)(135.35±3.46 mg GAE/g, p<0.05) whereas the highest total flavonoid content (TFC) was in green tea (GT) (48.76±0.69 mg QE/g, p<0.05) both of which were maintained from a pharmacy. Among the bergamot samples, the highest TPC and TFC values were in filtered fruit juice (BFFJ) as 197.35±6.29 mg GAE/100 mL; and 94.14±1.39 mg QE/100 mL; p<0.05, respectively. GT showed the highest antioxidant capacity in IRC and TEAC assays (2.29±0.12 mM TE/g; and 2.32±0.07 mmol TE/mg, p<0.05). The lowest DPPH IC50 was identified in ML from a pharmacy (6.95±0.08 ?g/mL; p<0.01). BFFJ had the highest IRC (2.94±0.031 mM TE/10?L), TEAC (5.14±0.084 mmol TE/10 ul) and the lowest DPPH IC50 value (10.561±0.17 ?L). GT from a pharmacy and 1mg/mL concentration BFLFJ (filtered and lyophilized) were associated with the lowest hydroxyl radical scavenger activity (0.171±0.013 ?M MDA equivalent, p<0.05 and 0.144±0.015 ?M MDA equivalent, p<0.05). Conclusion: BFLFJ and GT got the highest attention due to high TPC, TFC, antioxidant and low prooxidant properties. Our results highlight the necessity of clarifying the value of bergamot and GT in this field with further studies

Percutaneous successful closure of dual atrial septal defect with two Amplatzer septal occluder devices

We report a case of percutaneous dual atrial septal defect closure with two Amplatzer septal occluder devices

Percutaneous closure of perimembranous ventricular septal defect with an Amplatzer Duct Occluder in a dextrocardia patient

In this article we report an unusual case of dextrocardia patient with perimembranous ventricular septal defect (VSD) whose defect is closed by percutaneous method with Amplatzer Duct Occluder-II device. To our best knowledge, this was the first time this device has been used to close a membranous defect in a patient with dextrocardia. Our case demonstrates the feasibility of percutaneous VSD closure in challenging patients by using appropiate techniques and devices for particular patients. (C) 2009 Elsevier Ireland Ltd. All rights reserved

Thrombus Formation on the Delivery Sheath during Transcatheter Atrial Septal Defect Closure

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