D-π-D chromophores based on dithieno[3,2-b:2′,3'-d]thiophene (DTT) : potential application in the fabrication of solar cell

In this work, four stable dithieno[3,2-b:2′,3'-d]thiophene-based π-extended molecules were designed and synthesized via a Pd-catalysed Sonogashira coupling reaction. The structures of these symmetrical compounds, including dithieno[3,2-b:2′,3'-d]thiophene (DTT) as the π-center and various donor (D) groups, were determined on the basis of NMR spectral data, elemental analysis, and X-ray crystallography. The photo-physical properties of the DTT-based derivatives 2 were fully investigated in both solution and solid state. The notable optical features of their solid-state powders showed significant red-shift in comparison with the luminescence of their dilute dichloromethane solutions. These results combined with the theoretical calculations indicate that they are promising candidates for the several applications in electronic and optoelectronic devices, as well as organic dyes for solar cells

Negative Effects of the Urban River Pollution on the Environment and Human Health in Bangladesh

Based on research findings, Bangladesh’s river water, crucial for domestic, agricultural, and industrial use, has long been in a terrible situation. There have been numerous instances of significant contamination in the waterways surrounding Dhaka city, including the Buriganga River, and in Chattogram city, including the Karnaphuli River, over the past 40 years. The existing data demonstrate that other urban rivers, particularly Karatoa, Teesta, Rupsa, Pasur, and Padma, are also in severe condition due to the disposition of huge pollutants. Contaminants flowing with the water have severely polluted the downstream areas of the rivers. High metal concentrations are frequently observed in river water during the dry season. In the Buriganga River and at certain locations in the Turag, Balu, Sitalakhya, and Karnaphuli Rivers, the presence of dissolvable oxygen (DO) is nearly zero. NO3, NO2, and PO4-3 pollution has also occurred in many rivers. Most rivers have Cr, Zn, Fe, Pb, Cu, Cd, Mn, As, and Ni concentrations beyond the legal limit for drinking water. In contrast, some rivers have metal concentrations above the legal irrigation water limit. The majority of the rivers, particularly the peri-urban rivers in Dhaka city, Teesta, Korotoa, Rupsha, Karnaphuli, and Meghna Rivers, have significantly higher metal concentrations, according to sediment data. Metal concentrations in sediment are generally higher than USEPA standards in most rivers. Metal concentrations in fish and crops demonstrate metal bioaccumulation. The trend in metal concentration follows the order of water, fish, and sediment. It has been shown that crops irrigated with tainted water contain dangerous metals. The analysis of daily intake data on carcinogenic and noncarcinogenic substances reveals that consuming contaminated food can seriously impact human health

A tightly clustered hepatitis E virus genotype 1a is associated with endemic and outbreak infections in Bangladesh.

BACKGROUND: Hepatitis E virus (HEV) infection is endemic in Bangladesh and there are occasional outbreaks. The molecular characteristics and pathogenesis of endemic and outbreak HEV strains are poorly understood. We compared the genetic relatedness and virulence associated mutations of endemic HEV strains with outbreak strains. METHODS: We analyzed systematically collected serum samples from HEV immunoglobulin M (IgM) positive patients attended at Bangabandhu Sheikh Mujib Medical University, Dhaka from August 2013 to June 2015. HEV RNA positive samples were subjected to whole genome sequencing. Genotype and subtype of the strains were determined by phylogenetic analysis. Virulence associated mutations e.g. acute viral hepatitis (AVH), fulminant hepatic failure (FHF), chronic hepatitis, ribavirin treatment failure (RTF), B and T cell neutralization epitopes were determined. RESULTS: 92 HEV immunoglobulin M (IgM) antibody positive plasma samples (43 in 2013-2014 and 49 in 2014-2015) were studied. 77.1% (70/92) of the samples were HEV RNA positive. A 279 bp open reading frame (ORF) 2 and ORF 3 sequence was obtained from 54.2% (38/70) of the strains. Of these 38 strains, whole genome sequence (WGS) was obtained from 21 strains. In phylogenetic analysis of 38 (279 bp) sequence all HEV sequences belonged to genotype 1 and subtype 1a. Further phylogenetic analysis of 21 HEV WGS, Bangladeshi HEV sequences clustered with genotype 1a sequences from neighboring countries. Within genotype 1a cluster, Bangladesh HEV strains formed a separate cluster with the 2010 HEV outbreak strains from northern Bangladesh. 80.9 to 100% of the strains had A317T, T735I, L1120I, L1110F, P259S, V1479I, G1634K mutations associates AVH, FHF and RTF. Mutations in T cell recognition epitope T3, T5, T7 was observed in 76.1%, 100% and 100% of the strains respectively. CONCLUSION: Strains of HEV genotype 1a are dominant in Bangladesh and are associated with endemic and outbreak of HEV infection. HEV isolates in Bangladesh have high prevalence of virulence associated mutations and mutation which alters antigenicity to B and T cell epitopes

Synthesis and fluorescence emission properties of D-π-D monomers based on dithieno[3,2-b:2′,3′-d]thiophene

We herein present four highly fluorescent and stable D-π-D monomers (2), which were designed and synthesized using different types of aryl substituent as the donor via a Suzuki-Miyaura coupling reaction. We have studied these four symmetrical chromophores by UV–vis absorption and fluorescence emission spectroscopy both in solution and the solid state. This research shows that the introduction of the aryl groups can effectively reduced the HOMO-LUMO gap of thiophene chromophore resulting in a shift of the wavelength of the absorption and fluorescence emission. The notable optical features of their solid-state powders also exhibited a distinct red-shift in comparison with the emissions of their dilute solutions. These results combined with the theoretical calculations (B3LYP/6–31G*) indicate that these systems are promising candidates in the fabrication of organic electroluminescence devices

Data and figure

To evaluate the T-cell mediated immune responses in T2DM, this study assessed and compared IFN-γ and IL-2 secreting PBMCs against the SARS-CoV-2 BNT162b2 mRNA vaccine. </p

Tackling a global epidemic threat: Nipah surveillance in Bangladesh, 2006-2021.

Human Nipah virus (NiV) infection is an epidemic-prone disease and since the first recognized outbreak in Bangladesh in 2001, human infections have been detected almost every year. Due to its high case fatality rate and public health importance, a hospital-based Nipah sentinel surveillance was established in Bangladesh to promptly detect Nipah cases and respond to outbreaks at the earliest. The surveillance has been ongoing till present. The hospital-based sentinel surveillance was conducted at ten strategically chosen tertiary care hospitals distributed throughout Bangladesh. The surveillance staff ensured that routine screening, enrollment, data, and specimen collection from suspected Nipah cases were conducted daily. The specimens were then processed and transported to the reference laboratory of Institute of Epidemiology, Disease Control and Research (IEDCR) and icddr,b for confirmation of diagnosis through serology and molecular detection. From 2006 to 2021, through this hospital-based surveillance platform, 7,150 individuals were enrolled and tested for Nipah virus. Since 2001, 322 Nipah infections were identified in Bangladesh, 75% of whom were laboratory confirmed cases. Half of the reported cases were primary cases (162/322) having an established history of consuming raw date palm sap (DPS) or tari (fermented date palm sap) and 29% were infected through person-to-person transmission. Since the initiation of surveillance, 68% (218/322) of Nipah cases from Bangladesh have been identified from various parts of the country. Fever, vomiting, headache, fatigue, and increased salivation were the most common symptoms among enrolled Nipah patients. Till 2021, the overall case fatality rate of NiV infection in Bangladesh was 71%. This article emphasizes that the overall epidemiology of Nipah virus infection in Bangladesh has remained consistent throughout the years. This is the only systematic surveillance to detect human NiV infection globally. The findings from this surveillance have contributed to early detection of NiV cases in hospital settings, understanding of Nipah disease epidemiology, and have enabled timely public health interventions for prevention and containment of NiV infection. Although we still have much to learn regarding the transmission dynamics and risk factors of human NiV infection, surveillance has played a significant role in advancing our knowledge in this regard

Historical information on Nipah surveillance sites, 2006 to 2021.

Shape file source of the map: https://gadm.org/download_country.html Shape file license of the map: https://gadm.org/license.html.</p

Characteristics of NiV patients, including clinical symptoms and signs, exposure, and outcome of NiV infections reported from Bangladesh between April 2001 to December 2021.

Characteristics of NiV patients, including clinical symptoms and signs, exposure, and outcome of NiV infections reported from Bangladesh between April 2001 to December 2021.</p

Distribution of individuals tested for NiV infection at ten sentinel hospitals in Bangladesh, January 2007 to December 2021.

The red bars represent the number of NiV-positive persons (n = 139), and the grey bars indicate the number of NiV-negative individuals (n = 7011). The small green squares signify the proportion (%) of Nipah cases detected in the calendar year. The horizontal dark blue line implies the overall annual proportion of 1.94%. * In 2007, active sites started reporting the total number of suspected Nipah encephalitis/pneumonitis cases admitted every month.</p