Study of the Biological Activities of the Seeds of the Plant Ceratonia Siliqua L. Recovered in the Bejaia Region

Background: Ceratonia siliqua is a plant that belongs to the Fabaceae family. It is frequently used in our culinary and medical traditions to fight cholesterol, acute diarrhea and digestive disorders. Methods: The hydrogen atom or electron donation abilities of the corresponding extracts and some pure compounds were measured from the bleaching of the purple-colored methanol solution of 2, 20-diphenylpicrylhydrazyl (DPPH), studying the anti-inflammatory effect by measuring the volume of the edema of the paw that has received carrageenan 1%. Antimicrobial activity in vitro was screened by using disc diffusion and micro-dilution methods. Results: The determination of the polyphenols of the methanolic extracts of the seeds reveals the richness of our extracts in polyphenols is 30 mg of gallic acid / g of extract. The aqueous and methanolic extract flavonoid assay shows that they contain high levels of flavonoids with contents of 07 and 10 mg equivalent of quercetin / g of extract respectively. The aqueous and methanolic extracts of Ceratonia siliqua seeds from the Bejaia region could bring the stable free radical 2.2 diphenyl-1-picrylhydrazyl (DPPH) to yellow-colored diphenylpicrylhydrazine with respective IC 50 values of 0.7 mg/ml and 0.2 mg/ml. They exhibit lower antioxidant activity than ascorbic acid (0.038 μg / ml). Determination of anti-inflammatory activity revealed that our aqueous and methanolic extracts of Ceratonia siliqua L seeds are able to reduce edema up to 81.89%. The methanoid extracts of Ceratonia siliqua L. seeds have a medium antibacterial action against bacteria: E. coli (13 mm), Staphylococcus aureus (12 mm) and Pseudomonas aeruginosa (12 mm). On the other hand, the aqueous extracts of the seeds of Ceratonia siliqua L have a weak antibacterial action against the same bacteria with a diameter of inhibition of 9 mm. However, the aqueous extracts of Ceratonia siliqua L seeds are endowed with a very important inhibitory action against candida albicans and it is similar to that of the antibiotic, antifungal Econazole (1%). Conclusion: According to the results observed, the two extracts of the seeds and pods have a potential anti-free radical and antioxidant measured compared to the standard antioxidant used. The results of the antimicrobial activity carried out in vitro on the 3 bacterial strains indicate that the two methanolic extracts of this plant have low antibacterial activity

Crystal structure of (1S,2R,4R,9S,11S,-12R)-9α-hydroxy-4,8-dimethyl-12-[(thio-morpholin-4-yl)methyl]-3,14-dioxatri-cyclo[9.3.0.02,4]tetradec-7-en-13-one

The authors thank the Unit of Support for Technical and Scientific Research (UATRS, CNRST) for the X-ray measurements.Peer reviewedPublisher PD

12-Anilinomethyl-9α-hy­droxy-4,8-dimethyl-3,14-dioxatricyclo­[9.3.0.02,4]tetra­dec-7-en-13-one

The title compound, C21H27NO4, was synthesized from 9α-hy­droxy­parthenolide, which was isolated from the chloro­form extract of the aerial parts of Anvillea radiata. The asymmetric unit contains two independent mol­ecules. In each, the ten-membered ring displays an approximative chair-chair conformation. Each of the five-membered rings adopts a flattened envelope conformation, the C(H)—C—C(H) atoms representing the flap lie out of the mean plane through the remaining four atoms by 0.443 (2) and 0.553 (2) Å. The dihedral angle between the least-squares planes through the ten- and five-membered rings in the two mol­ecules are similar [22.54 (17) and 23.39 (14)°]. In the crystal, mol­ecules are linked by O—H⋯O, O—H⋯N and N—H⋯O hydrogen bonds

Study of the Anti-Inflammatory and Healing Properties of the Rhizomes of Carthamus Caeruleus L. (Asteraceae) Harvested in the Region of Tipaza

Background: In some regions of Algeria, in Tipaza, natural medicine still occupies a place of choice in the treatment of many pathologies, among these natural remedies are quoted extracts of the rhizomes of Carthamus caeruleus L are used to treat burns with these astringent properties. Medicinal plant extracts contain a variety of phenolic compounds that are attributed to various biological activities (antioxidant and antimicrobial activity). Methods: Our present study was conducted on the roots of Carthamus caeruleus L. harvested in the Tipaza region during the spring season. In order to promote this plant, we evaluated the anti-inflammatory activity and healing activity of the aqueous extract of the powder of the roots of Carthamus caereulus L. Studying the anti-inflammatory effect by measuring the volume of the edema of the paw that has received carrageenan 1%. Circular incision of 2 cm in diameter was made in Wistar rats to evaluate the healing activity of the aqueous pasty extract of the rhizomes of Carthamus caeruleus L at 100 mg/kg. Results: They show that aqueous extracts of Carthamus caeruleus L rhizomes at the dose of 100 mg/kg are opposed to the increased edema induced by the carrageenan 1% in rats with a percentage of inhibition of edema volume of 87.34% at the 6th hour.  Concerning the healing activity, the results show that the application of the aqueous extracts of the roots of Carthamus caereulus L.at dose of 100 mg/kg on the wounds causes their healing at the end of 14 days. Conclusion: Aqueous extracts of the roots of Carthamus caereulus L. show healing properties and anti-inflammatory effects. These results could justify the use of this plant in traditional medicine against inflammatory diseases

5,9-Dihy­droxy-9-methyl-3,6-dimethyl­ene-3a,4,5,6,6a,7,8,9,9a,9b-deca­hydro­azuleno[4,5-b]furan-2(3H)-one

The title compound, C15H20O4, was synthesized from 9α-hy­droxy­parthenolide (9α-hy­droxy-4,8-dimethyl-12-methyl­ene-3,14-dioxatricyclo­[9.3.0.02,4]tetra­dec-7-en-13-one), which was isolated from the chloro­form extract of the aerial parts of Anvillea radiata. The seven-membered ring has a chair conformation, while the five-membered rings display twisted conformations. The dihedral angle between the seven-membered ring and the lactone ring is 21.69 (10)°. In the crystal, mol­ecules are linked into chains propagating along the c axis by inter­molecular O—H⋯O hydrogen bonds; an intra­molecular O—H⋯O link also occurs

Methyl 2-(3a,8a-dimethyl-4-oxodeca­hydro­azulen-6-yl)acrylate

The title compound, C16H24O3, was synthesized from ilicic acid, which was isolated from the aerial part of Inula viscosa­ (L) Aiton [or Dittrichia viscosa­ (L) Greuter]. The asymmetric unit contains two independent mol­ecules, in each of which the seven-membered ring shows a chair conformation, whereas the five-membered ring presents disorder. In the two molecules, three C atoms in the five-membered ring are disordered over two positions with site-occupancy factors of 0.53/0.47 and 0.83/0.17. The dihedral angle between the two rings is different in the two mol­ecules [31.7 (3) and 47.7 (7)°]. The crystal structure is stabilized by weak inter­molecular C—H⋯O hydrogen-bond inter­actions

6-Nitro-2,3-dihydro-1H-pyrrolo­[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

In the two mol­ecules of the asymmetric unit of the title compound, C12H11N3O4, the seven-membered diazepine ring adopts a boat conformation (with the two phenyl­ene C atoms representing the stern and the methine C atom the prow). The five-membered pyrrole ring, which has an envelope conformation, makes dihedral angles of 60.47 (10) and 54.69 (9)° with the benzene ring of the benzodiazepine unit in the two mol­ecules. In the crystal, inter­molecular N—H⋯O hydrogen bonds and π–π stacking inter­actions [centroid–centroid distance = 3.8023 (7)–3.8946 (7) Å] lead to the formation of a three-dimensional framework

2-Isopropyl-4-meth­oxy-5-methyl­phenyl benzoate

The title compound, C18H20O3, a hemisynthetic product, was obtained by the reaction of benzoyl chloride and p-methoxy­thymol. The structure comprises two benzene rings bridged by a carboxyl group; the dihedral angle between the rings is 73.54 (8)°