The effect of COVID-19 infection on retinal nerve fiber layer and ganglion cell complex layer thicknesses

Aim:  To evaluate the possible effects of SARS-CoV-2 infection on retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GC-IPL) thicknesses. Method: Patients who had been infected by SARS-CoV-2 and hospitalized because of severe pneumonia were found out from the database of COVID-19 pandemic hospital and formed the patient group. The control group was composed of non-COVID-19 age-matched subjects. The mean and fragmented RNFL and GC-IPL thicknesses were measured by optical coherence tomography (OCT), and compared between two groups, statistically. Results: Patient group 34 eyes of 34 subjects (18 male, 16 female) and 31 eyes of 31 subjects (14 male, 17 female) in the control group were enrolled. The mean age and gender were not statistically different between groups (p:0.56, 0,57, respectively).A statistically significant difference was not found between groups in terms of mean, superior, inferior, temporal, nasal RNFL thicknesses and mean superior, inferior, temporal, and nasal GC-IPL thicknesses. Conclusion: The mean and fragmented RNFL and GC-IPL thicknesses measured by OCT were not statistically different in patients who had moderate disease course and recovered from COVID-19 infection

Corneal topography, anterior segment and high-order aberration assessments in children with >= 2 diopter astigmatism

Purpose To assess topographic findings, anterior segment parameters and high-order aberrations (HOAs) by using corneal tomography in children with 2 diopters (dp) or more astigmatism. Methods Children with 2 dp or more astigmatism (study group) and children with astigmatism less than 1 dp (control group) were recruited. Corneal astigmatism, mean, steep, flat keratometry (K) findings, anterior and posterior K results and anterior segment parameters including anterior chamber depth, kappa distance, horizontal corneal diameter, mean, central, middle, peripheral corneal thicknesses (CT), white-to-white (WTW) distance and pupil diameter were measured by Galilei G4 Dual Scheimpflug corneal tomography. HOAs were also assessed and compared between groups. Results Fifty-eight eyes of 37 children in the study group and 37 eyes of 37 children in the control group were enrolled. The mean ages of groups were 9.7 +/- 2.4 years and 9.3 +/- 1.6 years in study and control groups, respectively. The mean astigmatism was 3.3 +/- 1.1 dp and 0.5 +/- 0.3 dp in study and control groups, respectively (p < 0.05). Total corneal astigmatism was 3.3 +/- 0.84 dp and 1.14 +/- 0.47 dp in study and control groups, respectively (p < 0.05). There was a significant difference between groups in terms of posterior steep K and posterior astigmatism values. Among anterior segment parameters, mean CT and WTW values were statistically different between groups. HOAs were found to be statistically different between groups. Conclusion Higher posterior corneal astigmatism, thinner mean CT and lower WTW distance were found in children with 2 dp or more astigmatism. Besides, HOAs were much more in these astigmatic children