Smart Home using Internet

This paper presents a lowcost, flexible home devices control and monitoring system using an embedded arduino micro-web server, with real IP connectivity for accessing and controlling devices and appliances remotely using Android based Smart phone app running on android platform. The proposed system does not require a dedicated server PC with respect to similar systems and offers a novel communication protocol to monitor and control the home environment with real time graphical interface. Devices such as light switches, temperature sensors, smoke/gas sensors and sirens can been integrated in the system to increase the feasibility and effectiveness of the proposed smart home system. However every load of the home can be controlled using SENSOR SWITCH. Sensor switch is integrated with the Ethernet system. Therefore in proposed system real time interface is possible

The Reproductive Performance of Native Osmanabadi Goat of India

Among the goat breeds of India, Osmanabadi goat breed is one of the most popular goat breed of the arid and semi-arid region of Maharashtra state. Historically this breed is known to exist on Deccan Plateau since decades. The name Osmanabadi is derived from its origin, i.e. Osmanabad district in Maharashtra state. The breeds is distributed mainly in 2 southern states of India viz. Western Telangana and North Eastern Karnataka state and are having largest contribution to meat production in Southern India as their meat is very tasty when compared with local breeds. The Osmanabadi breed is suited to all types of rearing systems, the most ideal being the semi-intensive system (grazing and closed enclosure) where higher production has been observed compared to extensive (grazing system) and intensive systems (zero grazing system). Osmanabadi goats reared in the Maharashtra, Karnataka and Telangana border region had been analysed with reproductive parameters and found that, the female kids attend puberty at the age of 349.8 ± 6.9 days with 17.45 ± 0.23 Kg body weight. The average gestation period found was 152.24 ± 0.24 days. The mean age at first kidding was found to be 494.4 ± 8.1 days. The average duration of post-partum anoestrus period was 67.34 ± 6.31 days which was responsible for short inter-kidding interval which shows high profile reproductive efficiency. The mean kidding interval recorded as 232.62 ± 5.45 days. Majority of kidding resulted in single births (87.27%) and with only 12.73% of multiple births. Breeding season and kidding season of Osmanabadi goats was observed from the month of June to September and November to February as a major

SOLUBILITY ENHANCEMENT OF GLIBENCLAMIDE USING MESOPOROUS SILICA

Glibenclamide is a BCS Class II drug and poses a major problem during formulation development. In the present study, adsorption onto various carriers was used to enhance the solubility of glibenclamide. It was observed that solubility of glibenclamide was greatly enhanced by adsorbing onto mesoporous silica. The increase in solubility of poorly soluble drugs is often associated with the generation of supersaturation, which results in the risk of drug precipitation. HPMC E5 was used as precipitation inhibitor to maintain sink condition for a longer duration. A 32 full factorial design was adopted to optimize the ratio of glibenclamide (X1) and mesoporous silica as a carrier (X2) and the effect of different ratios was studied on percent yield, percent drug loading, and percent drug release. X-ray powder diffraction (XRPD) and Differential scanning calorimetry studies were performed to investigate any possible interaction in between glibenclamide and mesoporous silica. An optimum batch of drug adsorbate was used to prepare immediate-release tablets. The tablets prepared were evaluated for thickness, uniformity of weight, hardness, friability, in-vitro disintegration time, and in vitro drug release study

Health-status outcomes with invasive or conservative care in coronary disease

BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline

Initial invasive or conservative strategy for stable coronary disease

BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, 121.8 percentage points; 95% CI, 124.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used