Florid cemento osseous dysplasia and dentygerous cyst in a patient with apert syndrome: A case report

Apert syndrome is a rare congenital malformation characterized by craniocinocytosis, craniofacial anomalies and symmetric syndactyly of the feet and hands. Oral manifestations of Apert syndrome usually represents bifid uvula, malposition of the teeth, severe open bite, tooth decay and periodontal diseases. Fluorid cemento-osseous dysplasia is usually asymptomatic slow-growing non-neoplastic fibro-osseous lesions. Lesions are detected by routine radiographic examination. The aim of this case report is to present dentigerous cyst and florid cemento-osseous displasia in a patient with Apert syndrome. A 38-year-old female patient with a history of Apert syndrome referred to Marmara University, Faculty of Dentistry, Clinic of Oral and Dentomaxillofacial Radiology due to pain and swelling. On panoramic radiography, unilocular, hyperdense lesion with regular borders was observed in the anterior region of the mandible. Cone-beam computed tomography (CBCT) was performed for further examination of the lesion and perforation of buccal bone cortex was seen. Additionally, a regular monolocular hypodense lesion was observed in the anterior region of maxilla. A biopsy was performed to examine the lesion histopathologically. Histopathologic examination was performed to evaluate the lesions and the lesion in the mandible was diagnosed as cemento-osseous dysplasia. Because the lesion was multifocal, it was considered and compatible with fluoride cemento-osseous dysplasia. The lesion in the maxilla was diagnosed as dentigerous cyst on histopathologic examination. The diagnosis of fluoride cemento-osseous dysplasia is established by definite radiological and histopathological evaluation. In asymptomatic cases of fluorid cemento-osseous dysplasia, treatment is not required but patients should be followed up regularly. Practitioners should take into consideration the oral and dental findings in patients with Apert syndrome which rarely appear.KEYWORDS Apert Syndrome, florid cementoosseous dysplasia, dentigerous cys

Desmoplactic fibroma of the mandible, a rare case.

Desmoplastic fibroma (DF), a rare benign locally aggressive neoplasm of bone composed of bland spindle cells and abundant collagen. In this report, we present a case of DF in the mandible. Differential diagnosis and treatment strategy are discussed with a literature review. An 11-year-old male patient with swelling and pain complaint in left mandible visited our clinic. As a result of radiological and clinical examination, a well and sclerotic demarcated lytic lesion was detected.A computed tomographic scan demonstrated 3 × 11cm multifocal expansive lesions at the left mandible. The lesion has excised. As a result of histopathological examination the lesion turned out to be DF. Although we know that recurrence rates raises to 55-72% from 17% when local excision preferred over hemimandiblectomy or segmental resection; to do not disturb the natural maxillofacial skeletal progress. A periodic follow-up is warranted

Assessment of p53 and Bcl-2 Protein Expressions in Oral Lichen Planus and Oral Squamous Cell Carcinoma

ObjectiveMalignant transformation is suggested to be a consequence of alterations in cell cycle control, and this potential of oral lichen planus (OLP) is still controversial. The aim of this study was to evaluate the malignant transformation of OLP comparing with oral squamous cell carcinoma (OSCC) by immunohistochemistry.Study DesignBcl-2 and p53 expressions were determined by immunohistochemistry in 100 oral mucosal biopsies including normal oral mucosa (n=20), OLP (n=40) and OSCC (n=40).ResultsThere were no significant differences in p53 and bcl-2 expressions between OLP and OSCC cases. However p53 expression was higher in OLP and OSCC compared to normal epithelium (p<0.05).ConclusionsThe results of this study suggest that the expression of these proteins might be an evidence of the potential of malignant transformation process in OLP. Therefore, there is a need for long term follow-up of patients with OLP to detect any malignant alteration.Keywordslichen planus, bcl-2, p53, oral squamous cell carcinom