QOL after RT or OP for uterine cervix cancer

This study aimed to research the post-treatment quality of life (QOL) between radiotherapy (RT)- and operation (OP)-treated early cervical cancer survivors, using separate questionnaires for physicians and patients. We administered an observational questionnaire to patients aged 20–70 years old with Stages IB1–IIB cervical cancer who had undergone RT or OP and without recurrence as outpatients for ≥6 months after treatment. We divided 100 registered patients equally into two treatment groups (n = 50 each). The average age was 53 and 44 years in the RT and OP groups, respectively. The RT group included 34 and 66% Stage I and II patients, respectively, whereas the OP group included 66 and 34% Stage I and II patients, respectively. The OP group included 58% of patients with postoperative RT. Combination chemotherapy was performed in 84 and 48% of patients in the RT and OP groups, respectively. On the physicians’ questionnaire, we observed significant differences in bone marrow suppression (RT) and leg edema (OP). On the patients’ questionnaire, significantly more patients had dysuria and leg edema in the OP group than in the RT group, and severe (Score 4–5) leg edema was significantly higher in the post-operative RT group than in the OP only group. The frequency of sexual intercourse decreased after treatment in both groups. On the patients’ questionnaire, there were no significant differences between the two groups regarding sexual activity. These findings are useful to patients and physicians for shared decision-making in treatment choices. The guidance of everyday life and health information including sexual life after treatment is important

患者とのズレ(不一致)に繋がる看護師の思考・感情・行動の特徴 : 看護場面の再構成による自己との対峙から

本研究の目的は、研究者自らの看護実践場面から看護師としての思考・感情・行動の特徴を抽出し、看護の目的を達成するための看護師の思考・感情・行動のあり方を考察することである。患者とのズレを感じた15場面を再構成し、各場面における患者-看護師間のコミュニケーション過程を、E.ウィーデンバックの自己評価項目に照らし、第三者と振り返った。その結果、ズレに繋がる看護師の思考・感情・行動の特徴として【看護師の思いを先行させること】が抽出された。しかし同時に看護師の思考や感情は看護師としての内的な限界にもなり得る一方、患者の援助へのニードと、時間・場・他職種との意見の相違といった【ケアの場の制約】として存在する外的な限界との間に生じる葛藤を打破する資源にもなり得ることも確認された。これらのことから、看護師は、現在の力を自覚し、臨床の場で生じる矛盾を調和的に解消していくための訓練が必要であり、その方法として自身の実践場面を再構成し第三者と振り返る過程そのものの有効性が示唆された。The purpose of the point book study extracts the characteristic of though

Systemic Delivery of hGhrelin Derivative by Lyophilizate for Dry Powder Inhalation System in Monkeys

Ghrelin is the peptide that increases the hunger sensation and food intake and is expected to be clinically applied for treatment of diseases such as cachexia and anorexia nervosa. In the clinical application of ghrelin, injections are problematic in that they are invasive and inconvenient. Thus, we aimed to develop a formulation that can eliminate the need for injections and can be applied clinically. We prepared formulations of an hGhrelin derivative, in which the octanoyl group essential for expression of activity is modified to avoid rapid des-acylation, using lyophilizate for a dry powder inhalation (LDPI) system. The formulation of hGhrelin derivative was optimized by the addition of phenylalanine, of which the fine particle fraction of 5 µm or less was 41.7 ± 3.8%. We also performed pharmacokinetic/pharmacodynamic tests in monkeys using the optimum formulation that can be applied clinically. The absolute bioavailability of inhaled hGhrelin derivative with respect to that intravenously injected was 16.9 ± 2.6%. An increase in growth hormone was shown as an effect of the inhaled hGhrelin derivative similar to intravenous injection. The LDPI formulation can deliver the hGhrelin derivative systemically, and it is expected to be applied clinically as a substitute for injections

Lesions of supramammillary nucleus decreae self-grooming behavior of rats placed in an open field

Aim : Although subcortical regions send numerous efferent fibers to the hippocampus, their involvement in hippocampal functions has not been fu11y elucidated. The aim of this study was to determine the efTect of the supram ammillary nucleus (SuM) on the hippocampus. Methods : Neurons within the SuM of rats were destroyed by local injections of an excitotoxin, ibotenic acid, and the efTects of the SuM-lesion on behaviors in an open field were investigated. Results: SuM lesions increased distance traveled, movement time and latency to start grooming, while they decreased time spent grooming. SuM lesions had no efTect on rearing frequency or immobility time. Conclusion : Prolonged exploration and decrease in the total time spent grooming observed in the SuM-lesioned rats were consistent with the beh avi oral characteri stics of hippocamp al -lesioned rats of the previ ous report s, suggesting that the SuM is involved in the establishment of spatial memory by hippocampus during the initial exploration of a novel environment. In addition, the reduction of grooming in the SuM-lesioned animal suggests that SuM may be involved in emotion, such as anxiety. The results ofthis study show the involvement ofthe SuM in hippocampal function and in anxiety perceived in anovel environment