The effect of cholecalciferol supplementation on allograft function in incident kidney transplant recipients: A randomized controlled study

It is unknown whether cholecalciferol supplementation improves allograft outcomes in kidney transplant recipients (KTRs). We conducted a single-center randomized, double-blind, placebo-controlled trial of daily 4000 IU cholecalciferol supplementation in KTRs at 1-month posttransplant. The primary endpoint was the change in eGFR from baseline to 12-month posttransplant. Secondary endpoints included severity of interstitial fibrosis and tubular atrophy (IFTA) at 12-month posttransplant and changes in urinary biomarkers. Of 193 randomized patients, 180 participants completed the study. Changes in eGFR were 1.2 mL/min/1.73 m2 (95% CI; −0.7 to 3.1) in the cholecalciferol group and 1.8 mL/min/1.73 m2 (95% CI, −0.02 to 3.7) in the placebo group, with no significant between-group difference (−0.7 mL/min/1.73 m2 [95% CI; −3.3 to 2.0], p = 0.63). Subgroup analyses showed detrimental effects of cholecalciferol in patients with eGFR <45 mL/min/1.73 m2 (Pinteraction <0.05, between-group difference; −4.3 mL/min/1.73 m2 [95% CI; −7.3 to −1.3]). The degree of IFTA, changes in urine albumin-to-creatinine ratio, or adverse events including hypercalcemia and infections requiring hospitalization did not differ between groups. In conclusion, cholecalciferol supplementation did not affect eGFR change compared to placebo among incident KTRs. These findings do not support cholecalciferol supplementation for improving allograft function in incident KTRs. Clinical trial registry: This study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) as UMIN000020597 (please refer to the links below). UMIN-CTR: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000023776.Doi Y., Tsujita M., Hamano T., et al. The effect of cholecalciferol supplementation on allograft function in incident kidney transplant recipients: A randomized controlled study. American Journal of Transplantation 21, 3043 (2021); https://doi.org/10.1111/ajt.16530

Physicochemical Properties of Amphoteric β-Lactam Antibiotics. III. Stability, Solubility, and Dissolution Behavior of Cefatrizine and Cefadroxil as a Function of pH

金沢大学大学院自然科学研究科分子作用学金沢大学薬学

Shock Excitation in Narrow Line Regions Powered by AGN Outflows

Outflows in the Active Galactic Nucleus (AGN) are considered to play a key role in the host galaxy evolution through transfer of a large amount of energy. A Narrow Line Region (NLR) in the AGN is composed of ionized gas extending from pc-scales to kpc-scales. It has been suggested that shocks are required for ionization of the NLR gas. If AGN outflows generate such shocks, they will sweep through the NLR and the outflow energy will be transferred into a galaxy-scale region. In order to study contribution of the AGN outflow to the NLR-scale shock, we measure the [\ion{Fe}{2}]$\lambda12570$/[\ion{P}{2}]$\lambda11886$ line ratio, which is a good tracer of shocks, using near-infrared spectroscopic observations with WINERED (Warm INfrared Echelle spectrograph to Realize Extreme Dispersion and sensitivity) mounted on the New Technology Telescope. Among 13 Seyfert galaxies we observed, the [\ion{Fe}{2}] and [\ion{P}{2}] lines were detected in 12 and 6 targets, respectively. The [\ion{Fe}{2}]/[\ion{P}{2}] ratios in 4 targets were found to be higher than 10, which implies the existence of shocks. We also found that the shock is likely to exist where an ionized outflow, i.e., a blue wing in [\ion{S}{3}]$\lambda9533$, is present. Our result implies that the ionized outflow present over a NLR-scale region sweeps through the interstellar medium and generates a shock.Comment: Accepted for ApJ, 20 pages, 11 figure

Polynomorphs of Japanese Alpine Plants(3)

Article環境科学年報14:35-44(1992)research repor

Autoimmune Pancreatitis Exhibiting Multiple Mass Lesions

Our case is a first report of autoimmune pancreatitis with multiple masses within the pancreas which was pathologically diagnosed by endoscopic ultrasound-guided fine needle aspiration and treated by steroid. The masses disappeared by steroid therapy. Our case is informative to know that autoimmune pancreatitis sometimes exhibits multiple masses within the pancreas and to diagnose it without unnecessary surgery