1 research outputs found
Ag/FeCo/Ag Core/Shell/Shell Magnetic Nanoparticles with Plasmonic Imaging Capability
Magnetic nanoparticles (NPs) have
been used to separate various
species such as bacteria, cells, and proteins. In this study, we synthesized
Ag/FeCo/Ag core/shell/shell NPs designed for magnetic separation of
subcellular components like intracellular vesicles. A benefit of these
NPs is that their silver metal content allows plasmon scattering to
be used as a tool to observe detection by the NPs easily and semipermanently.
Therefore, these NPs are considered a potential alternative to existing
fluorescent probes like dye molecules and colloidal quantum dots.
In addition, the Ag core inside the NPs suppresses the oxidation of
FeCo because of electron transfer from the Ag core to the FeCo shell,
even though FeCo is typically susceptible to oxidation. The surfaces
of the Ag/FeCo/Ag NPs were functionalized with ε-poly-l-lysine-based hydrophilic polymers to make them water-soluble and
biocompatible. The imaging capability of the polymer-functionalized
NPs induced by plasmon scattering from the Ag core was investigated.
The response of the NPs to a magnetic field using liposomes as platforms
and applying a magnetic field during observation by confocal laser
scanning microscopy was assessed. The results of the magnetophoresis
experiments of liposomes allowed us to calculate the magnetic force
to which each liposome was subjected