17 research outputs found
Increases in Nonspecific Immunoglobulin E and Eosinophils after H. pylori Eradication
Helicobacter pylori infection has been reported to be inversely associated with allergic disorders. We by chance experienced a patient with atrophic gastritis who presented marked elevations of both nonspecific serum immunoglobulin E and eosinophil counts after H. pylori eradication. A 49-year-old Japanese man received eradication of H. pylori using lansoprazole 60 mg/day, amoxicillin 1,500 mg/day, and clarithromycin 400 mg/day for 7 days. Serum immunoglobulin E increased to more than four times its pretreatment level, 306 → 485 → 1,325 U/ml, and peripheral eosinophil counts increased to more than three times, 99 → 139 → 298 per μl. Deducing from the current case, H. pylori eradication might develop allergic disorders in some patients
Immunohistochemical analyses of parathyroid hormone-dependent downregulation of renal type II Na-Pi cotransporters by cryobiopsy
The “in vivo cryotechnique” (IVCT) is a new method of morphological analysis which has the advantage of freezing tissues in living animals without stopping their blood circulation. The purpose of this study was to investigate the effect of parathyroid hormone (PTH) on renal type II Na-Pi transporters (NaPi-IIa and NaPi-IIc) and ”cryobiopsy” (CB) using special cryoforceps as a simple method of the IVCT. The kidney tissues were biopsied at various time points after PTH administration by CB using liquid nitrogen as the cryogen. By hematoxylin-eosin (HE) staining the kidney tissues, well-frozen areas without visible ice crystals were obtained in the tissue surface areas, and the brush border membrane (BBM) of proximal tubules was well preserved at a light microscopic level. Immunohistochemical evaluation showed that PTH downregulated NaPi-IIa and NaPi-IIc at the BBM, being controlled by a different mechanism. In this method, the PTHinduced internalization of NaPi-IIc from microvilli to subapical compartments was not observed in the tissue preparations. NaPi-IIc protein appears to be degraded in microvilli of the proximal tubular cells after the injection of PTH. We suggest that CB using liquid nitrogen is useful to investigate renal type II Na-Pi transporters at the light microscopic level
Residual Strain Dependence on Matrix Structure in RHQ-Nb3Al Wires by Neutron Diffraction Measurement
We prepared three types of non-Cu RHQ-Nb3Al wire samples with different
matrix structures: an all-Ta matrix,a composite matrix of Nb and Ta with a Ta
inter filament, and an all-Nb matrix. Neutron diffraction patterns of the wire
samples were measured at room temperature in J-PARC "TAKUMI". To obtain
residual strains of materials, we estimated lattice constant a by multi-peak
analysis in the wire. Powder sample of each wire was measured, where the powder
was considered to be strain-free. The grain size of all the powder samples was
below 0.02 mm. For wire sample with the all-Nb matrix, we also obtained lattice
spacing d by a single-peak analysis. Residual strains of Nb3Al filament were
estimated from the two analysis results and were compared. Result, residual
strains obtained from the multi-peak analysis showed a good accuracy with small
standard deviation. The multi-peak analysis results for the residual strains of
Nb3Al filament in the three samples were all tensile residual strain in the
axial direction, they are 0.12%, 0.12%, and 0.05% for the all-Ta matrix, the
composite matrix, and the all-Nb matrix, respectively. Difference in the
residual strain of Nb3Al filament between the composite and all-Nb matrix
samples indicates that type of inter-filament materials show a great effect on
the residual strain. In this paper, we report the method of measurement, method
of analysis, and results for residual strain in the tree types of non-Cu
RHO-Nb3Al wires.Comment: 7 pages, 8 figure