A Variation of the Present Star Formation Activity of Spiral Galaxies

The star formation rate in spiral galaxies is considered to be decreasing continuously with time in a time scale of $10^{9}$ yr. The present star formation activity, on the other hand, shows various degrees among galaxies. We make a new data set of 1681 nearby spiral galaxies from available databases and study the statistics of the present star formation activity. We analyze far-infrared and optical B-band surface brightnesses of the H II regions and the non-H II regions in M~31 and show that a far-infrared-to-optical B-band flux ratio, f(FIR)/f(B), is a useful indicator of the present star formation activity of spiral galaxies. For the sample galaxies, we make the distribution diagram of log (f(FIR)/f(B)) versus log L(B) for each morphological type. The distribution of f(FIR)/f(B) has a dispersion of one to two orders of magnitude even within the same morphological type of galaxies, implying that the star formation activities of spiral galaxies changes discontinuously in a short time scale. Analyzing the log (f(FIR)/f(B)) versus log L(B) correlation, we suggest that the most active star formation in galaxies does not continue longer than 10^{8} yr. We also construct a universal distribution histogram of log (f(FIR)/f(B)) for each morphological type. The earlier-type spirals tend to show larger variation of the present star formation activity. We discuss the correlation between the present star formation activity and the structures and environments of galaxies. We suggest that the short-term variation occurs primarily due to internal processes which may change with the morphological type of galaxies.Comment: LaTeX file, 32 pages including tables without figs. 30 figures at ftp://ftp.kusastro.kyoto-u.ac.jp/pub/atomita/preprint/p1489/p1489.tar.gz . To appear in PASJ, Vol. 48, No. 2, April 1996 issu

Proximal Tubule Cell Hypothesis for Cardiorenal Syndrome in Diabetes

Incidence of cardiovascular disease (CVD) is remarkably high among patients with chronic kidney disease (CKD), even in the early microalbuminuric stages with normal glomerular filtration rates. Proximal tubule cells (PTCs) mediate metabolism and urinary excretion of vasculotoxic substances via apical and basolateral receptors and transporters. These cells also retrieve vasculoprotective substances from circulation or synthesize them for release into the circulation. PTCs are also involved in the uptake of sodium and phosphate, which are critical for hemodynamic regulation and maintaining the mineral balance, respectively. Dysregulation of PTC functions in CKD is likely to be associated with the development of CVD and is linked to the progression to end-stage renal disease. In particular, PTC dysfunction occurs early in diabetic nephropathy, a leading cause of CKD. It is therefore important to elucidate the mechanisms of PTC dysfunction to develop therapeutic strategies for treating cardiorenal syndrome in diabetes

Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium

Receptor-mediated endocytosis is a pivotal function of renal proximal tubule epithelial cells (PTECs) to reabsorb and metabolize substantial amounts of proteins and other substances in glomerular filtrates. The function accounts for the conservation of nutrients, including carrier-bound vitamins and trace elements, filtered by glomeruli. Impairment of the process results in a loss of such substances and development of proteinuria, an important clinical sign of kidney disease and a risk marker for cardiovascular disease. Megalin is a multiligand endocytic receptor expressed at clathrin-coated pits of PTEC, playing a central role in the process. Megalin cooperates with various membrane molecules and interacts with many intracellular adaptor proteins for endocytic trafficking. Megalin is also involved in signaling pathways in the cells. Megalin-mediated endocytic overload leads to damage of PTEC. Further studies are needed to elucidate the mechanism of megalin-mediated endocytosis and develop strategies for preventing the damage of PTEC

Characteristics of Kiso Ultra-Violet Excess Galaxies

We examined the general characteristics of the Kiso Ultra-violet Excess Galaxies (KUGs). We present for the first time the quantitative expressions for the criteria of the KUGs; the boundary color separating the KUGs from the non-KUGs is (B-V)_{T} = 0.74 and the KUG degrees of UV strength are found to correlate with the mean (B-V)_{T} colors. We investigate the nature of the KUGs, a sample of blue galaxy population, and show that (1) about a half of the KUGs are spiral galaxies with Sb to Scd, (2) the KUGs are biased to late-type galaxies and include early-type galaxies with young star populations, and (3) the KUGs are preferably found among less luminous galaxies with log L(B) < 10. The KUGs also contain the post-starburst galaxies, many of which are found among the blue galaxy population at intermediate redshifts. The analysis of the far-infrared data shows that a typical present-to-past star formation rate for a KUG is 0.4.Comment: Revised version of astro-ph/9706088, accepted manuscript for AJ; uuencoded gzip'ed tar'ed file containing 25 files; a manuscript (aasms4), 7 tables (aj_pt4), 17 PS figures; To be appeared in The Astronomical Journal, Vol. 114, No. 5 (1997 November issue

Task support system by displaying instructional video onto AR workspace

This paper presents an instructional support system based on aug-mented reality (AR). This system helps a user to work intuitively by overlaying visual information in the same way of a navigation system. In usual AR systems, the contents to be overlaid onto real space are created with 3D Computer Graphics. In most cases, such contents are newly created according to applications. However, there are many 2D videos that show how to take apart or build elec-tric appliances and PCs, how to cook, etc. Therefore, our system employs such existing 2D videos as instructional videos. By trans-forming an instructional video to display, according to the user’s view, and by overlaying the video onto the user’s view space, the proposed system intuitively provides the user with visual guidance. In order to avoid the problem that the display of the instructional video and the user’s view may be visually confused, we add var-ious visual effects to the instructional video, such as transparency and enhancement of contours. By dividing the instructional video into sections according to the operations to be carried out in order to complete a certain task, we ensure that the user can interactively move to the next step in the instructional video after a certain op-eration is completed. Therefore, the user can carry on with the task at his/her own pace. In the usability test, users evaluated the use of the instructional video in our system through two tasks: a task involving building blocks and an origami task. As a result, we found that a user’s visibility improves when the instructional video is transformed to display according to his/her view. Further, for the evaluation of visual effects, we can classify these effects according to the task and obtain the guideline for the use of our system as an instructional support system for performing various other tasks

International comparison of pharmaceutical industry payment disclosures in the UK and Japan: implications for self-regulation, public regulation, and transparency

BackgroundSelf-regulation of payment disclosure by pharmaceutical industry trade groups is a major global approach to increasing transparency of financial relationships between drug companies and healthcare professionals and organisations. Nevertheless, little is known about the relative strengths and weaknesses of self-regulation across countries, especially beyond Europe. To address this gap in research and stimulate international policy learning, we compare the UK and Japan, the likely strongest cases of self-regulation of payment disclosure in Europe and Asia, across three dimensions of transparency: disclosure rules, practices, and data.ResultsThe UK and Japanese self-regulation of payment disclosure had shared as well unique strengths and weaknesses. The UK and Japanese pharmaceutical industry trade groups declared transparency as the primary goal of payment disclosure, without, however, explaining the link between the two. The rules of payment disclosure in each country provided more insight into some payments but not others. Both trade groups did not reveal the recipients of certain payments by default, and the UK trade group also made the disclosure of some payments conditional on recipient consent. Drug company disclosure practices were more transparent in the UK, allowing for greater availability and accessibility of payment data and insight into underreporting or misreporting of payments by companies. Nevertheless, the share of payments made to named recipients was three times higher in Japan than in the UK, indicating higher transparency of disclosure data.ConclusionsThe UK and Japan performed differently across the three dimensions of transparency, suggesting that any comprehensive analysis of self-regulation of payment disclosure must triangulate analysis of disclosure rules, practices, and data. We found limited evidence to support key claims regarding the strengths of self-regulation, while often finding it inferior to public regulation of payment disclosure. We suggest how the self-regulation of payment disclosure in each country can be enhanced and, in the long run, replaced by public regulation to strengthen the industry’s accountability to the public

Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes)

Objectives The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval. Methods The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values/min, confirmed at two or more separate visits. Results Ten cats (17 eyes) were included. The mean ± SD (range) age and STT-1 values in affected eye(s) were 6.1 ± 5.7 (0.2–16) years and 2.4 ± 3.1 (0–8) mm/min, respectively. Concurrent ocular surface disease was bilateral in 5/10 cats. Clinical signs included conjunctivitis (14/17 eyes), corneal ulceration (6/17 eyes), non-ulcerative keratitis (4/17 eyes), symblepharon (4/17 eyes), eosinophilic keratitis (3/17 eyes), corneal sequestrum (3/17 eyes), corneal fibrosis (2/17 eyes) and meibomitis (2/17 eyes). Management included topically applied lacrimomimetics, antiviral drugs, corticosteroids or immunomodulatory drugs; orally administered famciclovir; or surgical procedures, in various combinations. Response to therapy (defined as an increase in STT-1 value of ⩾5 mm/min) was transient (seen at a single reassessment) in 65% of eyes and sustained (seen at ⩾2 consecutive reassessments) in 18% of eyes. Conclusions and relevance Clinical features seen in cats with low STT-1 values are described, although the association between aqueous deficiency and the reported ocular changes is unknown at this time. We encourage clinicians to assess the tear film in cats with ocular surface disease, and initiate therapy with lacrimomimetics if STT-1 values are repeatedly below normal. Such information will further define aqueous tear deficiency in cats, providing a better understanding of disease prevalence, pathogenesis and treatment