28 research outputs found

    Development of novel polymeric theranostic for the treatment of colorectal cancer

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    status and insulin resistance in diabetic peripheral neuropathy

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    Background: Complication of diabetes mellitus includes peripheral neuropathy which causes ischemic foot ulceration. Hyperglycemia and insulin resistance may accelerate the development of diabetic peripheral neuropathy. Objective: To assess the glycaemic status and insulin resistance for development of peripheral neuropathy in type 2 diabetes mellitus. Methods: This control case control study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2014 to June 2015. A total number of 150 Type 2 diabetic patients of both sexes were selected with age ranging 40 to 50 years. Among them, 75 patients with peripheral neuropathy were included in study group and 75 patients without peripheral neuropathy were control. For evaluation of glycaemic status, fasting serum glucose (FSG), Glycosylated hemoglobin (HbA1c) and to calculate insulin resistance by homeostatic model assessment for insulin resistance (HOMA-IR), fasting serum insulin (FSI), were estimated. For statistical analysis, unpaired Student’s ‘t’ test was done. Results: In this study, significant increase in FSG, HbA1c, FSI, HOMA-IR were found in diabetic subjects with peripheral neuropathy in comparison to control group. Conclusion: From the study results, it is concluded that poor glycaemic control and greater insulin resistance may be associated with diabetic peripheral neuropathy

    Livestock associated epidemiological information profiling in New Sandwip Island (Jahajerchar) of the Meghna estuary, Noakhali using participatory disease searching tool

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    Objective: The present study was conducted in New Sandwip island (Jahajerchar) of the Meghna estuary, Noakhali to explore animal species are being reared, their disease status, and also to finding out the constraints and opportunitities for keeping livestock in the island. Materials: Considering local knowledge as an epidemiological intelligence, the livestock species and their disease profile as well as livestock keeping problems were assessed through two focus group discussion with informants’ interview using Participatory Disease Searching (PDS) tools. The interview was conducted predominantly using semi-structured questionnaire (SSI) and other participatory epidemiology(PE) tools such as simple ranking (SR), pair-wise ranking (PWR), proportional pilling (PP) and transect work (visualization) were applied with flexibility to collect information. Results: PDS tools identified sheep (69%) is the main livestock species followed by cattle (16%) and buffalo (15%) in the island. The Peste des Petits Ruminant (PPR) in sheep (90%), anthrax in cattle (52%) and Haemorrgic Septicemia (HS) in buffalo (59%) were confirmed as top important species-wise diseases via the study. This place is prospect for sheep and buffalo raising rather than cattle. Lack of of shelter (Khella) for keeping livestock during adverse climatic condition, no access of portable water along with inadequate veterinary health care facilities were recognized as constraints for livestock raising in this island. Conclusion: This place is potential for sheep and buffalo raising rather than cattle. The study has validated the significance of accepting participatory disease searching tool in order to capture voluntarily submitted epidemiological data towards establishing a cost effective, unique national disease surveillance system in Bangladesh. [J Adv Vet Anim Res 2017; 4(3.000): 267-273

    Investigation of animal anthrax outbreaks in the humananimal interface at risky districts of Bangladesh during 20162017

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    Objective: The objective of the study was to explore the outbreak situation in terms of animal, place, and time towards minimizing the risk of animal infection at the source in future and subsequent spillover in human in the endemic rural settings. Methodology: An outbreak investigation team from the Department of Livestock Services visited in each of the outbreak sites to explore the event towards strengthening the control program in the future. Meat samples of the infected slaughtered animals were collected to confirm the causal agent of the animal outbreak using polychrome methylene blue microscopic examination technique. Participatory epidemiology tool such as semi-structured interview had been used in these investigations to realize the knowledge and practices of local people/cattle keepers on anthrax control and prevention in animal and human as well. Results: All identified affected human cases had been confirmed as a history of contact with the animal carcasses or handling/processing with infected meat. The level of awareness at the community level was not satisfactory for the prevention and control of anthrax at the source and further spillover in human. The infected slaughtered animals found to be in non-vaccinated status during the outbreak investigation and uncontrolled animal movement is considered to be responsible for new outbreaks in a vaccinated zone where enforcement of veterinary legislation is inadequate. Conclusion: A comprehensive preparedness and response strategy is to be obligatory for prevention, control and respond on anthrax in Bangladesh. Maximum vaccination coverage in the animal, increase community awareness of animal and human anthrax are also demanded for transmission of anthrax from animal to human. [J Adv Vet Anim Res 2018; 5(4.000): 397-404
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