G-20 economies and their environmental commitments: Fresh analysis based on energy consumption and economic growth

The impact of economic growth and energy use is still controversial regarding sustainability, and researchers have limited consensus in this regard. Electricity is considered more environmentally friendly compared with direct fossil fuel consumption. However, many developed economies still depend on fossil fuel sources for electricity generation. Therefore, this study attempted to verify the relationship between electricity consumption and carbon emissions in developed economies in the Group of Twenty (G20). Economic growth and foreign direct investment are other important variables for analyzing this relationship. For this purpose, a dataset from 1995–2018 was generated. The study used econometric methods including cross-sectional dependence, cointegration, Fully Modified Ordinary Least Square (FMOLS), Dynamic Ordinary Least Square (DOLS) estimators, and the Pair-wise panel Granger causality test to examine the relationship between dependent and independent variables. The findings show a positive relationship between electricity consumption and CO2 emissions. This indicates that electricity production is still dependent on sources that help increase CO2 emissions in G20 countries. Furthermore, the results show that gross domestic product and its square term confirm the Environmental Kuznets Curve (EKC) theory for these economies. These results suggest that policymakers promote green and clean electricity sources for sustainable economic growth

Subtype-Specific and Co-Occurring Genetic Alterations in B-cell Non-Hodgkin Lymphoma

B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL, such as diffuse large B-cell lymphoma, have been comprehensively interrogated at the genomic level, but rarer subtypes, such as mantle cell lymphoma, remain less extensively characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared using the same methodology to identify conserved or subtype-specific patterns of genomic alterations. Here, we employed a large targeted hybrid-capture sequencing approach encompassing 380 genes to interrogate the genomic landscapes of 685 B-NHL tumors at high depth, including diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, and Burkitt lymphoma. We identified conserved hallmarks of B-NHL that were deregulated in the majority of tumors from each subtype, including frequent genetic deregulation of the ubiquitin proteasome system. In addition, we identified subtype-specific patterns of genetic alterations, including clusters of co-occurring mutations and DNA copy number alterations. The cumulative burden of mutations within a single cluster were more discriminatory of B-NHL subtypes than individual mutations, implicating likely patterns of genetic cooperation that contribute to disease etiology. We therefore provide the first cross-sectional analysis of mutations and DNA copy number alterations across major B-NHL subtypes and a framework of co-occurring genetic alterations that deregulate genetic hallmarks and likely cooperate in lymphomagenesis

Case report: Filamin A mutation lung disease recognized in an eleven-year-old child

The loss of function due to mutations in the Filamin A (FLNA) gene may result in abnormality of the filamin A protein. Of the many clinical syndromes, this condition may produce chronic lung disease, which usually presents and is diagnosed in the infant/toddler age group. Its clinical pattern may mimic broncho-pulmonary dysplasia . It is part of the entities included in Childhood Interstitial Lung Disease (chILD) group of disorders . We are herein reporting a patient that was diagnosed with FLNA-associated lung disease at eleven years of age. This case provides a unique insight into the long-term course of lung disease in this illness and broadens our understanding of the spectrum of its presentation. Although the patient had symptoms early in life, the diagnosis was not entertained because of the rarity of the disorder, its atypical and clinically mild presentation, and discontinuous care due to parents moving to different cities for employment reasons. Her presentation to our institution was for pneumonia. Due to highly unusual chest x-ray images, asthenia, and early clubbing, an extensive work up included further imaging and a lung biopsy. The final diagnosis was confirmed by the detection of FLNA loss of function (LOF) gene mutation. This article is protected by copyright. All rights reserved

Control of Carbon Emissions by Promoting Economic Growth and Renewable Energy in Newly Emerging Economic Block

This research examines the effects of economic growth and energy consumption in the new developing economic block of Silk Road on carbon emissions (SERB). The energy consumption is further synthesized into renewable and non-renewable energy sources to distinguish their role in carbon emissions. This study considered panel data (1995-2014) of twenty-four middle-income countries along the Belt and Road initiative for empirical analysis. The fixed effect, random effect, and GMM methods were performed to confirm the cointegration relationship. Results highlighted the role of economic growth, renewable energy, and nonerasable energy on carbon emissions in the short and long run. Thus, it can be concluded that the newly emerging block resulting from Belt and Road initiative could get the maximum economic benefits of this project by using renewable energy sources. The new renewable energy projects may help increase clean energy and reduce carbon emissions in the emerging economic block due to the Belt and Road initiative

CCDC 776129: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures