Распространенность и факторы риска развития диабетической полиневропатии у стационарных больных сахарным диабетом 1-го типа

The NISLL scale and 7 electrophysiological tests were used to diagnose distal symmetric sensorimotor polyneuropathy in 120 inpatients with type 1 diabetes mellitus. The high rate (68.3%) of symptomatic or subclinical polyneuropathy was found. The duration of metabolic disturbances rather than short-term fluctuations in glycemia in terms of HbA1c levels was shown to mainly affect the degree of polyneuropathy in the patients of this group. The additional risk factors of polyneuropathy were retinopathy, smoking or hyperlipidemia.У лечившихся в стационаре больных сахарным диабетом 1-го типа (n = 120) проведена диагностика дистальной симметричной сенсорно-моторной полиневропатии с использованием шкалы NISLL и 7 электрофизиологических тестов. Выявлена высокая частота симптомной или субклинической полиневропатии (68,3 %). Показано, что основное влияние на выраженность полиневропатии у больных данной группы оказывает длительность нарушений метаболизма, но не кратковременные колебания гликемии по показателю HbA1c. Дополнительными факторами риска развития полиневропатии являлись наличие ретинопатии, курениеи гиперлипидемия

Proximal diabetic neuropathy (medical case)

A medical case of a rare form of damage to the peripheral nervous system in diabetes, proximal diabetic amyotrophy (PDA), is described. PDA is characterized by asymmetric proximal lesions in the leg combined with neuropathic pain, muscle weakness and atrophy, mild sensation disorders, increased protein in the cerebrospinal fluid and severe disability. The etiopathogenesis is determined by immune-mediated lesions of vessels, nerves and nerve roots, peri-and microvasculitis, ischemia of the peripheral nervous system structures. Combination treatment with glucocorticoid medications, thioctic acid drugs (Berlithion®) normalization of glycemic profile and symptomatic treatment of neuropathic pain, resulted in a marked positive effect - decreased motor defects and pain, and significant regression of sensory disorders

Folipidine, a new type quinoline alkaloid from plants of the Haplophyllum genus

The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC, was isolated from two plants of the Haplophyllum mints. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of [3,4-b]conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity

HIV ASSOCIATED TUBERCULOSIS (Overview)

The literature review highlights the current epidemiological situation of HIV and tuberculosis co-infection in the world and in Uzbekistan. The literature data on the development of various forms of tuberculosis in HIV-infected patients, clinical manifestations of tuberculosis, peculiarities of the course, diagnosis and prevention are presented