Extensibility of External Magnetic Potential at High Latitudes - Antarctica

We investigated the external magnetic potential due to solar forcing, with nine years of data during 2001-2009, coveringthe deep solar minimum (2006-2009), at two stations: one is in the polar cap -Vostok (78º27'S, 106º52’E; mag. lat 83oS) andanother is in the subauroral region - Maitri (70º45'S, 11º43'E: mag. lat 67oS) in Antarctica. The significance of the work isassociated with space weather prediction and its impact on planet Earth. We used Advance Composition Explorer (ACE)satellite data for the aforesaid period for a thorough understanding of influences due to solar wind origin and to compare theparameter observed in these regions. We used the spherical cap harmonic analysis (SCHA) function as a tool. The inferenceindicates that at Vostok the magnitude is enhanced throughout and depicts a broad ambient external magnetic potential. Itseems to be essentially the intensification of the region 1 currents whereas at Maitri intense electric fields are producedduring geomagnetic perturbations which drive a system of disturbed time Region 2 currents over the quiet time currents.During this scenario in Maitri there are noticeable peaks or enhancements in the magnetic potential that can be observedmainly during geomagnetic disturbances. Hence the regression relation developed for external magnetic potentialcalculation, in terms of solar wind parameters agrees well with polar cap region and the area is relatively less exploredearlier, the present investigation can be expected to add knowledge about that regime

Stac3 is a component of the excitation–contraction coupling machinery and mutated in Native American myopathy

Excitation-contraction coupling, the process that regulates contractions by skeletal muscles, transduces changes in membrane voltage by activating release of Ca2+ from internal stores to initiate muscle contraction. Defects in EC coupling are associated with muscle diseases. Here we identify Stac3 as a novel component of the EC coupling machinery. Using a zebrafish genetic screen, we generate a locomotor mutation that is mapped to stac3. We provide electrophysiological, Ca2+ imaging, immunocytochemical and biochemical evidence that Stac3 participates in excitation-contraction coupling in muscles. Furthermore, we reveal that a mutation in human STAC3 as the genetic basis of the debilitating Native American myopathy (NAM). Analysis of NAM stac3 in zebrafish shows that the NAM mutation decreases excitation-contraction coupling. These findings enhance our understanding of both excitation-contraction coupling and the pathology of myopathies

Extensibility of External Magnetic Potential at High Latitudes - Antarctica

19-26We investigated the external magnetic potential due to solar forcing, with nine years of data during 2001-2009, covering the deep solar minimum (2006-2009), at two stations: one is in the polar cap -Vostok (78º27'S, 106º52’E; mag. lat 83S) and another is in the subauroral region - Maitri (70º45'S, 11º43'E: mag. lat 670S) in Antarctica. The significance of the work is associated with space weather prediction and its impact on planet Earth. We used Advance Composition Explorer (ACE) satellite data for the aforesaid period for a thorough understanding of influences due to solar wind origin and to compare the parameter observed in these regions. We used the spherical cap harmonic analysis (SCHA) function as a tool. The inference indicates that at Vostok the magnitude is enhanced throughout and depicts a broad ambient external magnetic potential. It seems to be essentially the intensification of the region 1 currents whereas at Maitri intense electric fields are produced during geomagnetic perturbations which drive a system of disturbed time Region 2 currents over the quiet time currents. During this scenario in Maitri there are noticeable peaks or enhancements in the magnetic potential that can be observed mainly during geomagnetic disturbances. Hence the regression relation developed for external magnetic potential calculation, in terms of solar wind parameters agrees well with polar cap region and the area is relatively less explored earlier, the present investigation can be expected to add knowledge about that regime