25 research outputs found
Effects of Neonatal Neural Progenitor Cell Implantation on Adult Neuroanatomy and Cognition in the Ts65Dn Model of Down Syndrome
As much of the aberrant neural development in Down syndrome (DS) occurs postnatally, an early opportunity exists to intervene and influence life-long cognitive development. Recent success using neural progenitor cells (NPC) in models of adult neurodegeneration indicate such therapy may be a viable option in diseases such as DS. Murine NPC (mNPC, C17.2 cell line) or saline were implanted bilaterally into the dorsal hippocampus of postnatal day 2 (PND 2) Ts65Dn pups to explore the feasibility of early postnatal treatment in this mouse model of DS. Disomic littermates provided karyotype controls for trisomic pups. Pups were monitored for developmental milestone achievement, and then underwent adult behavior testing at 14 weeks of age. We found that implanted mNPC survived into adulthood and migrated beyond the implant site in both karyotypes. The implantation of mNPC resulted in a significant increase in the density of dentate granule cells. However, mNPC implantation did not elicit cognitive changes in trisomic mice either neonatally or in adulthood. To the best of our knowledge, these results constitute the first assessment of mNPC as an early intervention on cognitive ability in a DS model
Interferometric Observations of Rapidly Rotating Stars
Optical interferometry provides us with a unique opportunity to improve our
understanding of stellar structure and evolution. Through direct observation of
rotationally distorted photospheres at sub-milliarcsecond scales, we are now
able to characterize latitude dependencies of stellar radius, temperature
structure, and even energy transport. These detailed new views of stars are
leading to revised thinking in a broad array of associated topics, such as
spectroscopy, stellar evolution, and exoplanet detection. As newly advanced
techniques and instrumentation mature, this topic in astronomy is poised to
greatly expand in depth and influence.Comment: Accepted for publication in A&AR